Neurotoxicity is one of the common side effects of anticancer chemotherapy. This pathology has a detectability of 38–90%. In some cases, it causes not only a significant decrease of life quality but also decrease of dose of cytostatics. Therefore, the tasks of early diagnosis, prevention and treatment of neurotoxicity are very relevant. Sensors underlying detection, especially neuroinflammation processes, are needed to develop an effective therapy for chemotherapy-induced neurotoxicity. The purpose of this topic is to study the results of chemotherapy studies on changes in the activity of proinflammatory cytokines. In this regard, the study of behavioral societies in neuropathic pain in animal models is of great importance. It was revealed that various manifestations of inflammation of pro-inflammatory cytokines, chemokines, damage to the dorsal ganglion or distal nerve endings are increasingly being detected. Detection of chemically induced peripheral neuropathy using animal models is necessary for in-depth identification of the cause-and-effect mechanisms of its development and selection of new, more effective methods of treatment.

The human immunodeficiency virus (HIV) continues to be a major global public health issue, having claimed 34 million lives so far. 38 million people are living with HIV around the world. 2 million of these people are children. The high medical, social and economic significance of HIV infection is determined by the widespread and severe course of the disease. Every year, up to 2.7 million new infections are registered worldwide. Up to 30 % of cases of HIV infection in pregnant women are detected for the first time during pregnancy-related examinations. Every year, 1.49 million babies are born to HIV-positive women worldwide. The current tasks are to preserve the health of women and reduce the risk of transmission of HIV infection from mother to child. The article analyzes the results of Russian and foreign studies concerning the problems of pregnant HIV-positive women, published in international databases. The aim of the work is to analyze the data of studies aimed at studying the effect of HIV infection on the course of pregnancy.

The purpose of the study was to investigate the association of carriage of rs9939609 polymorphism in the FTO gene with features of androgen status in men.

Material and methods. The observational one-stage examination of 139 male patients aged 22 to 69 years, admitted to a therapeutic hospital in a planned manner has been carried out in the Clinic of the Federal Research Center for Fundamental and Translational Medicine in the period 2020–2021. All fasting men in the morning (8:00–8:30) were carried out of an anthropometric examination to determine physical development, sampling of venous blood from the cubital vein to assess the hormonal parameters of androgen status, and taking a sample of the buccal epithelium for molecular genetic research. Based on the carriage of the rs9939609 (T>A) polymorphism of the FTO gene, the following groups (G) of patients were distinguished: G1 – wild-type homozygotes (WT/WT), G2 – heterozygotes (WT/A), G3 – homozygotes for the mutant allele (A/A).

Results and discussion. The statistically significant differences were found in the levels of total testosterone between G1 and G3 (11.6 vs 14.5 nmol/L, p = 0.010), as well as free testosterone in G1 compared to G2 (0.233 vs 0.287 nmol/L, p = 0.012) and G3 (0.233 vs 0.321 nmol/L, p = 0.002) when analyzing the clinical-anthropometric and hormonal features of the androgen status of the examined male patients in the selected groups. Assessment of the association revealed statistically significant positive correlations between the carriage of the mutant allele and the levels of total (r = 0.247; p = 0.013) and free (r = 0.296; p = 0.003) testosterone, and negative - with the frequency of androgen deficiency according to the free testosterone criteria (r = –0.240; p = 0.016).

Conclusions. It has been shown that the carriage of the A/A genotype of rs9939609 polymorphism of the FTO gene is associated with an increase in the levels of total and free testosterone, that indicates a protective effect against the development of androgen deficiency in men. The obtained results suggest that this effect is due to the epigenetic effect of the FTO gene protein product on the expression of other genes involved in the synthesis of androgens in the gonads, but also in the adrenal cortex since no association of the carriage of the rs9939609 polymorphism of the FTO gene with the DHEA-C level was found.

The questions concerning the terms of juvenile age body measurement as well as body composition variability remain relevance and academic novelty. Such studies results data are essential for systematic analysis on secular trend of young generation development.

Material and methods. Longitudinal study of physical development (length, body weight, muscle and fat component) of boys and girls aged 18 and 19, studying at 1–2 courses of university and living in a dormitory has been applied.

Results and discussion. In boys and girls aged 18–19, body length and body weight have increased for 1 year on average by 1.5 and 0.9 cm and by 1.3 and 1.2 kg, respectively. In 22.6 % of boys and 54.8 % of girls body length does not change. The annual changes in the fat component are not reliable, whereas the muscle component increases significantly by 3 % in boys and by 0.8 % in girls. Students living in a dormitory often experience a lack of night sleep, they do not have enough physical activity, consume not enough calories, valuable proteins and fats. Because of this, physical development may deteriorate.

Conclusions. The annual variability of the indicators of physical development of students aged 18–19 years indicates the ongoing processes of growth and development, which are more pronounced in boys, in girls there is a tendency to stabilize the length of the body. Knowledge about the sensitivity of the body of first-year students mastering the requirements for studying at a university and independent living in a dormitory is necessary for the organization of work on pedagogical support during the adaptation of first-year students.

The lack of accurate information in the scientific literature highlighting the parameters of the fallopian tube funnel in the period from adolescence to old age was the reason for performing this work.

The aim of the study was to conduct a comparative analysis of the parameters of the external diameter of the fallopian tube funnel in women who gave birth in the period from adolescence to old age using autopsy specimens.

Material and methods. The work was based on the results of a morphometric study of both fallopian tubes in 126 women aged 16 to 88 years who had given birth and were divided into five groups (Group I comprised 24 women in their early teens, Group II comprised 26 women in their first adulthood, Group III comprised 23 women in their second adulthood, Group IV comprised 28 elderly women, Group V comprised 25 senile women.

Results. The parameters of the external diameter of the fallopian tubes of women in the period from adolescence to old age have no statistically reliable differences; there is a tendency for the values to increase with age. Comparative analysis of values of the external diameter of the right and left fallopian tubes funnels showed statistically reliable predominance of the right fallopian tube funnel parameters in adolescence and old age. In the first and second periods of adulthood and old age, no statistically significant difference in the parameters of the external diameter of the funnel of the right fallopian tube was found; the tendency to the predominance of the funnel diameter values of the right fallopian tube in comparison with the left one was noted.

Conclusions. The parameters of the external diameter of the fallopian tubes funnel in the period from adolescence to old age serve as reference values of the age morphological norm in women who have given birth, supplementing the currently available scientific data on the peculiarities of fallopian tube structure. These results can be applied to prospective basic and clinical research.

Introduction. In medical and dental colleges increased levels of psychological disturbances such as depression, anxiety and stress (DASS) among students which affect the way these students take care of patients. By identifying necessary modifications can be made to improve the quality of life among medical and dental students.

The aim of this study is to assess DASS among undergraduate medical and dental students in Mathura city, Uttar Pradesh, India.

Material and methods. The medical and dental college students from K.D. Medical College and K.D. Dental College students were included. A short questionnaire version of depression, anxiety and stress scale (DASS-21) was distributed and filled by students. Comparison among the variables was done using independent t-test with significance at p < 0.05.

Results. The study group comprised 415 subjects, 164 (39.51 %) males and 251 (60.48 %) females. Among them 297 (71.56 %) were medical students and 118 (28.43 %) were dental students. Out of a total of 297 medical students, the severity of overall DASS score was 38.8 ± 10.2 while depression score was 12.6 ± 4.0, anxiety score was 13.0 ± 4.1, stress score was 13.2 ± 4.3. Out of a total of 118 dental students the severity of overall DASS score was 37.8 ± 11.1 while depression scores was 12.2 ± 4.2, anxiety score was 12.9 ± 4.0, stress score was 12.7 ± 4.5. The overall mean DASS score and its dimensions were not significant based on gender.

Conclusions. Clinical years were more stressful than the nonclinical years. This suggests a need for special attention to the structure of the clinical program, particularly at the point of transition from the preclinical to the clinical phase.

The aim of the study was to compare the effect of glyproline peptides RGRGP (Arg-Gly-Arg-Gly-Pro), RGP (Arg-GlyPro), PRPGP (Pro-Arg-Pro-Gly-Pro) and PGPL (Pro-Gly-Pro-Leu) peptide substances at various concentrations on the free radical oxidation intensity of the brain tissues of Wistar males after intraperitoneal administration of peptide solutions after traumatic brain injury.

Material and methods. The brain tissue of Wistar males aged 2–3 months (n = 126) were used in the experiment. RGRGP, RGP, PRPGP, and PGPL peptides were provided by Academician N.F. Myasoyedov. Traumatic brain injury (TBI) was modeled by free fall of a load. From the second to the fifth day of the experiment, the animals were injected intraperitoneally with peptides. On the sixth day, the animals were taken out of the experiment. The activity of free radical oxidation was determined in freshly prepared homogenates of sections of the cerebral cortex by chemiluminescence (CL).

Results. TBI significantly enhance free-radical oxidation intensity of the neocortex in brain tissue of Wistar rats, and the studied peptides affect it in different ways - from a decrease in CL intensity (the minimum value in TBI + RGP 0.1 group) to its increase (the maximum value in TBI + RGPGP 0.1 group). The effect depends on the dose of glyproline.

Conclusions. The results obtained, based on the analysis of the free radical oxidation intensity of tissues, mainly indicate a different degree of correction of tissue homeostasis indicators. It can be assumed that Arg-Pro-Gly peptide can be the basis for the development of new drugs for post-stress rehabilitation after injuries of various levels and genesis.

Introduction. The study of various aspects of the stress-reactivity of the body’s immune system, along with the search for correction tools characterized by immunoregulatory properties, is one of the most relevant areas of physiology and pharmacology. Currently, neuropeptides belonging to the group of glурrоlins (the registered drug “sеlаnk” and the new compounds Рro-Glу-Рro-Leu and Рro-Glу-Рro) are of particular interest in practical application as promising bioregulators, in particular their effects on the processes of free radical oxidation, as well as the ability to restore changes from the immune system, including those formed in response to stress.

The aim of the study: was to study the effect of glурrоlins on the intensity of lipid peroxidation, catalase activity in the spleen and thymus of male rats under experimental information stress.

Material and methods. The study was performed on white nonlinear male rats on which the model of information stress, based on the formation of behavior in animals in a multi-alternative food-producing maze, was reproduced for 20 days. The initial content of malondialdehyde, the rate of spontaneous and ascorbate-dependent lipid peroxidation were determined by standard spectrophotometric methods, and the activity of catalase in the homogenate of the thymus and spleen of experimental animals was evaluated.

Results. Under the studied stress conditions, an increase in peroxidation processes was noted. Against the background of the introduction of sеlаnk, Рro-Glу-Рro and Рro-Glу-Рro-Leu, the suppression of the intensity of lipid peroxidation processes in the homogenates of the spleen and thymus tissue of male rats was established (a decrease in the initial level, the rate of spontaneous and ascorbate-dependent lipid peroxidation).

Conclusions. Injection of neuropeptides belonging to the group of glyprolins (sеlаnk, Рro-Glу-Рro-Leu and Рro-Glу-Рro) under informational stress conditions contributes to the suppression of the intensity of lipid peroxidation processes, which indicates the stress-protective and immunocorrective effect of the studied substances.

Aim of the study was to investigate the role of C-reactive protein as an indicator of multimorbidity in patients with arterial hypertension.

Material and methods. A retrospective archival study of the data of 1958 patients with arterial hypertension who were examined and treated at the clinic of the Federal Research Center for Fundamental and Translational Medicine (Novosibirsk) was carried out. 2 groups of patients were allocated depending on the concentration of C-reactive protein in the blood serum: normal and elevated (> 5 mg/l). A comparative analysis of the severity of polymorbidity, as well as clinical, laboratory and biochemical parameters in the selected groups were carried out.

Results. It has been established that patients with arterial hypertension with elevated values of C-reactive protein had higher rates of transnosological and transsystemic polymorbidity, accompanied by changes in lipid, carbohydrate and purine metabolism (a decrease in high-density lipoprotein cholesterol, an increase in the concentration of glucose and uric acid in blood serum, an increase in the index atherogenicity), as well as an increase in the content of fibrinogen in the blood serum.

Conclusions. The concentration of C-reactive protein in the blood serum can serve as a biochemical marker of polymorbidity in patients with arterial hypertension.