Body surface potential mapping in rats with stress-induce arterial hypertension
https://doi.org/10.18699/SSMJ20220307
Abstract
Studies on experimental animals allow us to approach the understanding of the mechanisms of changes in the electrical activity of the heart during morphofunctional rearrangements that occur as a result of the development of arterial hypertension (AH). Aim of the study was to investigate body surface potential mapping in young ISIAH rats with genetically determined stress-induced AH during ventricular depolarization. Material and methods. The study was carried out on 3-month-old ISIAH males (n = 10) weighing 250–300 g. Body surface potential mapping was performed using 64 electrodes evenly distributed around the chest of the animal. Results. Significantly higher systolic blood pressure was shown in ISIAH rats compared to Wistar rats (203 ± 14 and 125 ± 5 mm Hg, respectively), as well as heart relative mass, thickness of the left ventricle, right ventricle, and interventricular septum were significantly higher compared to Wistar. During the period of ventricular depolarization, a shift of the zone of negative cardiopotentials to the left-lateral region of the chest is shown in the period corresponding to the time the positive extremum reaches its maximum value in ISIAH rats compared to Wistar. An earlier time of formation, a significantly longer time to achieve the first and second inversion of cardiopotentials, a later time for the positive and negative extrema to reach their maximum values, a greater amplitude of the absolute value of the negative extremum, and a significantly longer total ventricular duration in ISIAH rats compared to Wistar rats were shown. Conclusions. The study give perspective to the use of body surface potential mapping for diagnosing the initial stages of the formation of myocardial hypertrophy in AH.
About the Authors
O. V. Suslonova
Federal Research Center Komi Scientific Center of UB of RAS
Russian Federation
Russian Federation
Olga V. Suslonova
167982, Syktyvkar, Kommunisticheskaya str., 24
Yu. V. Shorokhov
A.S. Pushkin Gymnasium
Russian Federation
Russian Federation
Yurij V. Shorokhov
167000, Syktyvkar, Sovetskaya str., 14
S. L. Smirnova
Federal Research Center Komi Scientific Center of UB of RAS
Russian Federation
Russian Federation
Svetlana L. Smirnova, candidate of biological sciences
167982, Syktyvkar, Kommunisticheskaya str., 24
I. M. Roshchevskaya
Federal Research Center Komi Scientific Center of UB of RAS
Russian Federation
Russian Federation
Irina M. Roshchevskaya, doctor of biological science, corresponding member RAS
167982, Syktyvkar, Kommunisticheskaya str., 24
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