Effect of gliprolines on lipid peroxidation rate in male rats’ immunocompetent organs under conditions of information stress

Introduction. The study of various aspects of the stress-reactivity of the body’s immune system, along with the search for correction tools characterized by immunoregulatory properties, is one of the most relevant areas of physiology and pharmacology. Currently, neuropeptides belonging to the group of glурrоlins (the registered drug “sеlаnk” and the new compounds Рro-Glу-Рro-Leu and Рro-Glу-Рro) are of particular interest in practical application as promising bioregulators, in particular their effects on the processes of free radical oxidation, as well as the ability to restore changes from the immune system, including those formed in response to stress.

The aim of the study: was to study the effect of glурrоlins on the intensity of lipid peroxidation, catalase activity in the spleen and thymus of male rats under experimental information stress.

Material and methods. The study was performed on white nonlinear male rats on which the model of information stress, based on the formation of behavior in animals in a multi-alternative food-producing maze, was reproduced for 20 days. The initial content of malondialdehyde, the rate of spontaneous and ascorbate-dependent lipid peroxidation were determined by standard spectrophotometric methods, and the activity of catalase in the homogenate of the thymus and spleen of experimental animals was evaluated.

Results. Under the studied stress conditions, an increase in peroxidation processes was noted. Against the background of the introduction of sеlаnk, Рro-Glу-Рro and Рro-Glу-Рro-Leu, the suppression of the intensity of lipid peroxidation processes in the homogenates of the spleen and thymus tissue of male rats was established (a decrease in the initial level, the rate of spontaneous and ascorbate-dependent lipid peroxidation).

Conclusions. Injection of neuropeptides belonging to the group of glyprolins (sеlаnk, Рro-Glу-Рro-Leu and Рro-Glу-Рro) under informational stress conditions contributes to the suppression of the intensity of lipid peroxidation processes, which indicates the stress-protective and immunocorrective effect of the studied substances.

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