Genetic contributions to sexual relationship dynamics: A narrative review
https://doi.org/10.18699/SSMJ20250407
Abstract
The stability and satisfaction of sexual relationships are vital for individual well-being and societal cohesion. Although psychological and social influences on these outcomes are well-documented, the study of their genetic underpinnings remains an emerging area of research. This review aims to synthesize and critically analyze genetic research findings related to the stability and satisfaction of sexual relationships, highlighting key genetic mechanisms and their implications.
Material and methods. This review synthesizes findings from 42 peer-reviewed publications published between 2003 and 2023, focusing on the genetic contributions to relationship stability and satisfaction.
Results. Evidence indicates that neuroticism, with a heritability estimate of approximately 40 %, strongly predicts relationship instability. In contrast, higher levels of agreeableness and extraversion are associated with greater satisfaction. The review examines how genetics influence personality traits, attachment patterns, emotional regulation, hormonal factors, sexual compatibility, communication behaviors, and mental health predispositions. It also highlights the interaction between genetic and environmental influences, supported by case studies and empirical research that demonstrate the complexity of these relationships.
Conclusions. This review discusses ethical implications and outlines future research opportunities, providing a comprehensive perspective on how genetics can shape successful sexual partnerships. By integrating genetic research with relationship science, it offers evidence-based insights to guide future interdisciplinary investigations.
About the Author
К. EskandarEgypt
Eskandar Kirolos
4034572, Helwan, Al Masaken Al Iqtisadeyah
References
1. Gordon A.M., Chen S. The role of sleep in interpersonal conflict. Social Psychological and Personality Science. 2013;5(2):168–175. doi: 10.1177/1948550613488952
2. Plomin R., von Stumm S. The new genetics of intelligence. Nat. Rev. Genet. 2018;19(3):148–159. doi: 10.1038/nrg.2017.104
3. Wray N.R., Ripke S., Mattheisen M., Trzaskowski M., Byrne E.M., Abdellaoui A., Adams M.J., Agerbo E., Air T.M., Andlauer T.M.F., … Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium. Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. Nat. Genet. 2018;50(5):668–681. doi: 10.1038/s41588-018-0090-3
4. Simpson J.A., Belsky J. Attachment theory within a modern evolutionary framework. In: Handbook of Attachment, Third Edition: Theory, Research, and Clinical Applications. 2016. Available at: clck.ru/3MfgWX
5. Canli T., Lesch K.P. Long story short: the serotonin transporter in emotion regulation and social cognition. Nat. Neurosci. 2007;10(9):1103–1109. doi: 10.1038/nn1964
6. Carter C.S. The oxytocin-vasopressin pathway in the context of love and fear. Front. Endocrinol. (Lausanne). 2017;8:356. doi: 10.3389/fendo.2017.00356
7. Roberts S.C., Havlicek J., Flegr J., Hruskova M., Little A.C., Jones B.C., Perrett D.I., Petrie M. Female facial attractiveness increases during the fertile phase of the menstrual cycle. Proc. Biol. Sci. 2004;271(Suppl 5):S270–S272. doi: 10.1098/rsbl.2004.0174
8. Reis H.T. The role of intimacy in interpersonal relations. Journal of Social and Clinical Psychology. 1990;9(1):15–30. doi: 10.1521/jscp.1990.9.1.15
9. Handbook of depression. 3rd edition. Eds. I.H. Gotlib, C.L. Hammen. Guilford Publications, 2015. 642 p.
10. Adams M.J., Howard D.M., Luciano M., Clarke T.K., Davies G., Hill W.D.; 23 and Me Research Team; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium; Smith D., Deary I.J., Porteous D.J., McIntosh A.M. Genetic stratification of depression by neuroticism: revisiting a diagnostic tradition. Psychol. Med. 2020;50(15):2526– 2535. doi: 10.1017/S0033291719002629
11. Nagel M., Jansen P.R., Stringer S., Watanabe K., de Leeuw C.A., Bryois J., Savage J.E., Hammerschlag A.R., Skene N.G., Muñoz-Manchado A.B., … Posthuma D. Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways. Nat. Genet. 2018;50(7):920–927. doi: 10.1038/s41588-018-0151-7
12. Lo M.T., Hinds D.A., Tung J.Y., Franz C., Fan C.C., Wang Y., Smeland O.B., Schork A., Holland D., Kauppi K., … Chen C.H. Genome-wide analyses for personality traits identify six genomic loci and show correlations with psychiatric disorders. Nat. Genet. 2017;49(1):152–156. doi: 10.1038/ng.3736
13. Maud C., Ryan J., McIntosh J.E., Olsson C.A. The role of oxytocin receptor gene (OXTR) DNA methylation (DNAm) in human social and emotional functioning: a systematic narrative review. BMC Psychiatry. 2018;18(1):154. doi: 10.1186/s12888-018-1740-9
14. Erkoreka L., Zumarraga M., Arrue A., Zamalloa M.I., Arnaiz A., Olivas O., Moreno-Calle T., Saez E., Garcia J., Marin E., … Basterreche N. Genetics of adult attachment: An updated review of the literature. World J. Psychiatry. 2021;11(9):530–542. doi: 10.5498/wjp.v11.i9.530
15. Tost H., Champagne F.A., Meyer-Lindenberg A. Environmental influence in the brain, human welfare and mental health. Nat. Neurosci. 2015;18(10):1421– 1431. doi: 10.1038/nn.4108
16. Riggs S.A., Sahl G., Greenwald E., Atkison H., Paulson A., Ross C.A. Family environment and adult attachment as predictors of psychopathology and personality dysfunction among inpatient abuse survivors. Violence Vict. 2007;22(5):577–600. doi: 10.1891/088667007782312159
17. Verbeke W., Bagozzi R.P., van den Berg W.E. The role of attachment styles in regulating the effects of dopamine on the behavior of salespersons. Front. Hum. Neurosci. 2014;8:32. doi: 10.3389/fnhum.2014.00032
18. Fearon R.P., Bakermans-Kranenburg M.J., van Ijzendoorn M.H., Lapsley A.M., Roisman G.I. The significance of insecure attachment and disorganization in the development of children’s externalizing behavior: a meta-analytic study. Child Dev. 2010;81(2):435–456. doi: 10.1111/j.1467-8624.2009.01405.x
19. Hariri A.R., Holmes A. Genetics of emotional regulation: the role of the serotonin transporter in neural function. Trends Cogn. Sci. 2006;10(4):182–191. doi: 10.1016/j.tics.2006.02.011
20. Gotlib I.H., Joormann J., Foland-Ross L.C. Understanding familial risk for depression: A 25-year perspective. Perspect. Psychol. Sci. 2014;9(1):94–108. doi: 10.1177/1745691613513469
21. Bardel G., Gross A.T., Neacsiu C.B. The neural circuitry of emotional regulation: evidence from multimodal imaging. Neurosci. Biomed. Eng. 2024;1(1):27– 41. doi: 10.35335/pwa46w25
22. Walum H., Westberg L., Henningsson S., Neiderhiser J.M., Reiss D., Igl W., Ganiban J.M., Spotts E.L., Pedersen N.L., Eriksson E., Lichtenstein P. Genetic variation in the vasopressin receptor 1a gene (AVPR1A) associates with pair-bonding behavior in humans. Proc. Natl. Acad. Sci. USA. 2008;105(37):14153–14156. doi: 10.1073/pnas.0803081105
23. Feldman R. What is resilience: an affiliative neuroscience approach. World Psychiatry. 2020;19(2):132– 150. doi: 10.1002/wps.20729
24. Roberts S.C., Gosling L.M., Carter V., Petrie M. MHC-correlated odour preferences in humans and the use of oral contraceptives. Proc. Biol. Sci. 2008;275(1652):2715–2722. doi: 10.1098/rspb.2008.0825
25. Winternitz J., Abbate J.L., Huchard E., Havlíček J., Garamszegi L.Z. Patterns of MHC-dependent mate selection in humans and nonhuman primates: a meta-analysis. Mol. Ecol. 2017;26(2):668–688. doi: 10.1111/mec.13920
26. Milinski M., Wedekind C. Evidence for MHCcorrelated perfume preferences in humans. Behavioral Ecol. 2001;12(2):140–149. doi: 10.1093/beheco/12.2.140
27. Gottesman I.I., Gould T.D. The endophenotype concept in psychiatry: etymology and strategic intentions. Am. J. Psychiatry. 2003;160(4):636–645. doi: 10.1176/appi.ajp.160.4.636
28. Caspi A., Moffitt T.E. Gene-environment interactions in psychiatry: joining forces with neuroscience. Nat. Rev. Neurosci. 2006;7(7):583–590. doi: 10.1038/nrn1925
29. Belsky J., Pluess M. Beyond diathesis stress: differential susceptibility to environmental influences. Psychol. Bull. 2009;135(6):885–908. doi: 10.1037/a0017376
30. Spotts E.L., Neiderhiser J.M., Towers H., Hansson K., Lichtenstein P., Cederblad M., Pederson N.L., Reiss D. Genetic and environmental influences on marital relationships. J. Fam. Psychol. 2004;18(1):107–119. doi: 10.1037/0893-3200.18.1.107
31. Starr L.R., Hammen C., Brennan P.A., Najman J.M. Serotonin transporter gene as a predictor of stress generation in depression. J. Abnorm. Psychol. 2012;121(4):810–818. doi: 10.1037/a0027952
32. Luo S., Yu D., Han S. Genetic and neural correlates of romantic relationship satisfaction. Soc. Cogn. Affect. Neurosci. 2016;11(2):337–348. doi: 10.1093/scan/nsv117
33. O’Connell K.S., Coombes B.J. Genetic contributions to bipolar disorder: current status and future directions. Psychol. Med. 2021;51(13):2156–2167. doi: 10.1017/S0033291721001252
34. Khabour O.F., Abu-Siniyeh A.A., Alzoubi K.H., Al-Sheyab N.A. Challenges faced by behavioral genetic studies: researchers perspective from the MENA region. Curr. Genomics. 2021;22(7):550–556. doi: 10.2174/1389202923666211216162141
35. Nuffield Council on Bioethics. Genetics and human behaviour: the ethical context. J. Int. Bioethique. 2003;14(3-4):171–192.
36. Hawkins A.K., Ho A. Genetic counseling and the ethical issues around direct-to-consumer genetic testing. J. Genet. Couns. 2012;21(3):367–373. doi: 10.1007/s10897-012-9488-8
37. McGuire A.L., Gabriel S., Tishkoff S.A., Wonkam A., Chakravarti A., Furlong E.E.M., Treutlein B., Meissner A., Chang H.Y., López-Bigas N., Segal E., Kim J.S. The road ahead in genetics and genomics. Nat. Rev. Genet. 2020;21(10):581–596. doi: 10.1038/s41576-020-0272-6
38. Armitage J.M., Wang R.A.H., Davis O.S.P., Haworth C.M.A. A polygenic approach to understanding resilience to peer victimisation. Behav. Genet. 2022;52(1):1–12. doi: 10.1007/s10519-021-10085-5
39. Bigos K.L., Hariri A.R. Neuroimaging: technologies at the interface of genes, brain, and behavior. Neuroimaging. Clin. N. Am. 2007;17(4):459–467. doi: 10.1016/j.nic.2007.09.005
40. Race and Health Observatory. Ethnic inequities in genomics and precision medicine: review report. 2024. Available at: https://www.nhsrho.org/research/ethnic-inequities-in-genomics-and-precision-medicinereview-report/
41. Lee H., Yoon D.E., Kim K. Genome editing methods in animal models. Anim. Cells Syst. (Seoul). 2020;24(1):8–16. doi: 10.1080/19768354.2020.1726462
42. Relationship science: integrating evolutionary, neuroscience, and sociocultural approaches. Eds.: O. Gillath, G. Adams, A. Kunkel. Washington: Amer. psychol. assoc., 2012. 254 p.