Parainfectious opsoclonus-myoclonus syndrome in a child on the example of a clinical case. Results of observation over 5 years

Abstract

   Opsoclonus-myoclonus syndrome is a rare symptom complex, the development of which can be induced by various factors, including infectious and oncopathology, and lead to persistent neurological deficiency, which requires timely diagnosis, treatment and long-term monitoring by specialists of various profiles. In the presented clinical case, a 2-year-old child developed a neurological syndrome in the form of a characteristic combination of opsoclonus, myoclonus, ataxia, psycho-emotional and insomnia disorders after immunization and non-specific general infectious manifestations. Stable clinical remission was achieved against the background of immunosuppressive therapy. Long-term observation for 5 years showed restoration of lost functions of the nervous system and rates of psychomotor development. The need for a comprehensive study of the long-term consequences of parainfectious opsoclonus-myoclonus syndrome is determined by the risk of developing persistent neurological deficit, developing other immunopathological conditions, relapse, and oncopathology. Diagnosis and determination of a treatment strategy for this disease in children is a complex interdisciplinary problem that requires long-term interaction and continuity of specialists of various profiles.