MORPHOLOGICAL CHARACTERISTICS OF TISSUE MICROREGION OF THE THYROID GLAND AT EXPERIMENTAL HYPOTHYROIDISM
https://doi.org/10.15372/SSMJ20190406
Abstract
Research purpose was to study the structures of the tissue microregion of the thyroid gland at an experimental hypothyroidism. Material and methods. The hypothyroidism model was created by mercazolilum intake at a dose of 5 mg/100 g of body mass for a month. The structure of tissue area (follicle, thyrocyte, interfollicular space) with morphometry and calculation of the integral indicators of the thyroid gland functional activity have been investigated by the light-optical and ultrastructural methods. Results and discussion. The morphophysiological structure of the thyroid gland is a tissue microregion. It unites a group of follicles and interfollicular space. The structure of the tissue miroregion have features of structural response to merkazolilum intake. The thyrostatic remedy changes the follicular organization of the thyroid gland to the predominance of small and medium follicles with signs of alteration. Thyrocytes have expansion and deformation of the granular endoplasmic reticulum cisterns, formation of intracellular colloid, reduction in the number of lysosomes and mitochondrions with their disorganization. The ratio of the area of the follicular epithelium, colloid and stroma changes at hypothyroidism. The portion of interstitial increases, there is an accumulation of tissue fluid because of weakening of a lymphatic drainage. Blood and lymphatic microvessels react by reducing the volume density to mercazolilum intake. Conclusion. The merkazolilum thyreostatics effects on morphology and metabolic and transport processes in tissue microregion. It testifies to decrease of thyroid function and the creation of hypothyroidism
adequate model.
About the Authors
O. V. Gorchakova
Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics SB RAS
Russian Federation
Russian Federation
candidate of medical sciences
630060, Novosibirsk, Timakov str., 2
V. N. Gorchakov
Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics SB RAS,
Novosibirsk State University
Russian Federation
Russian Federation
doctor of medical sciences, professor
630060, Novosibirsk, Timakov str., 2
630090, Novosibirsk, Pirogov str., 2
G. A. Demchenko
Institute of Human and Animal Physiology of the Scientific Committee of the Ministry of Education and Science of the Republic of Kazakhstan
Kazakhstan
Kazakhstan
doctor of medical sciences
Kazakhstan, 050060, Almaty, Al-Farabi av., 93
S. N. Abdreshov
Institute of Human and Animal Physiology of the Scientific Committee of the Ministry of Education and Science of the Republic of Kazakhstan
Kazakhstan
Kazakhstan
candidate of biological sciences
Kazakhstan, 050060, Almaty, Al-Farabi av., 93
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Review
For citations:
Gorchakova O.V., Gorchakov V.N., Demchenko G.A., Abdreshov S.N. MORPHOLOGICAL CHARACTERISTICS OF TISSUE MICROREGION OF THE THYROID GLAND AT EXPERIMENTAL HYPOTHYROIDISM. Сибирский научный медицинский журнал. 2019;39(4):46-54. (In Russ.) https://doi.org/10.15372/SSMJ20190406
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