Contribution of gut microbiome to pancreatic ductal adenocarcinoma development
https://doi.org/10.18699/SSMJ20250202
Abstract
Over the past decade, significant progress has been made in understanding the role of microbiota as an ecosystem that functions as a separate organ in a macroorganism. It is known that disturbances in the intestinal microflora affect the pathogenesis and progression of many human diseases. In particular, in gastrointestinal oncology, the gut microbiota affects tumor growth due to dysbiosis, the release of bacterial toxins, and the modulation of cell signaling pathways. Recent studies indicate that the intestinal microbiome plays an important role in the pathogenesis of pancreatic ductal adenocarcinoma, affecting carcinogenesis, immune response, and treatment efficacy. For example, such microorganisms as Porphyromonas gingivalis and Fusobacterium nucleatum are involved in oncogenesis by modulating the tumor microenvironment and stimulating immune responses, which promotes tumor growth, metastasis, and resistance to therapy. In addition, the involvement of kynurenine pathway metabolites (kynurenine, quinolinic acid, and 3-hydroxyanthranilic acid) in cancer has been previously investigated. The current review attempts to clarify the role of bacterial metabolites such as trimethylamine oxide and lipopolysaccharide in influencing antitumor immunity, suggesting potential targets for enhancing the response to immunotherapy. Implementation of microbiome research findings into clinical practice is an emerging field. Personalized therapy for pancreatic cancer is possible through understanding and manipulating the microbiome, which requires further research to develop optimal therapeutic strategies and evaluate combination approaches.
About the Authors
D. V. Zaitsev
Northern State Medical University of Minzdrav of Russia
Russian Federation
Russian Federation
Daniil V. Zaitsev
163069, Arkhangelsk, Troitsky ave., 51
E. S. Trukhacheva
Northern State Medical University of Minzdrav of Russia
Russian Federation
Russian Federation
Elizaveta S. Trukhacheva
163069, Arkhangelsk, Troitsky ave., 51
N. V. Davidovich
Northern State Medical University of Minzdrav of Russia
Russian Federation
Russian Federation
Nataliya V. Davidovich, candidate of medical sciences
163069, Arkhangelsk, Troitsky ave., 51
N. N. Kukalevskaya
Northern State Medical University of Minzdrav of Russia
Russian Federation
Russian Federation
Natalia N. Kukalevskaya
163069, Arkhangelsk, Troitsky ave., 51
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Review
For citations:
Zaitsev D.V., Trukhacheva E.S., Davidovich N.V., Kukalevskaya N.N. Contribution of gut microbiome to pancreatic ductal adenocarcinoma development. Сибирский научный медицинский журнал. 2025;45(2):19-29. (In Russ.) https://doi.org/10.18699/SSMJ20250202
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