Study of various groups of regulatory molecules during pregnancy against the background of chronic pyelonephritis
V. I. Shcherbakov,
O. O. Obukhova,
T. I. Ryabichenko,
G. A. Skosyreva,
O. M. Gorbenko,
T. G. Kosyanova https://doi.org/10.18699/SSMJ20230626
Abstract
The presence of infectious inflammatory process in a pregnant woman can lead to a disorder in the “mother – placenta – fetus” system.
Aim of the study was to investigate the level of regulatory and pro-inflammatory molecules in pregnancy occurring against the background of chronic pyelonephritis without exacerbation.
Material and methods. The concentration of IL-17A, monocytic chemotactic protein-1 (MCP-1), vascular endothelial growth factor (VEGF), and IgG autoantibodies to double-stranded DNA (AAT to nDNA) was determined in the blood serum of pregnant women with a gestation period of 36–40 weeks using ELISA.
Results. It has been shown that in the third trimester of pregnancy occurring against the background of chronic pyelonephritis without exacerbation, compared with a normal pregnancy, the level of MHP-1 and IL-17A increases, the content of VEGF decreases, and the concentration of AAT to nDNA does not change significantly. An increase in the proinflammatory cytokine IL17A and a decrease in VEGF level can lead to intrauterine fetal growth retardation due to inhibition of amino acid transporters in the placenta.
Conclusions. In pregnancy occurring against the background of chronic pyelonephritis without exacerbation, a change in the level of IL17A, MСP-1, VEGF can have a significant impact on the course of pregnancy.
About the Authors
V. I. Shcherbakov
Federal Research Center of Fundamental and Translational Medicine
Russian Federation
Russian Federation
Vladimir I. Shcherbakov - doctor of medical science.
630117, Novosibirsk, Timakova st., 2
O. O. Obukhova
Federal Research Center of Fundamental and Translational Medicine
Russian Federation
Russian Federation
Olga O. Obukhova - doctor of medical science.
630117, Novosibirsk, Timakova st., 2
T. I. Ryabichenko
Federal Research Center of Fundamental and Translational Medicine
Russian Federation
Russian Federation
Tatyana I. Ryabichenko - doctor of medical science.
630117, Novosibirsk, Timakova st., 2
G. A. Skosyreva
Federal Research Center of Fundamental and Translational Medicine
Russian Federation
Russian Federation
Galina A. Skosyreva - doctor of medical science.
630117, Novosibirsk, Timakova st., 2
O. M. Gorbenko
Federal Research Center of Fundamental and Translational Medicine
Russian Federation
Russian Federation
Olga M. Gorbenko - candidate of biological sciences.
630117, Novosibirsk, Timakova st., 2
T. G. Kosyanova
Federal Research Center of Fundamental and Translational Medicine
Russian Federation
Russian Federation
Tamara G. Kosyanova
630117, Novosibirsk, Timakova st., 2
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Review
For citations:
Shcherbakov V.I., Obukhova O.O., Ryabichenko T.I., Skosyreva G.A., Gorbenko O.M., Kosyanova T.G. Study of various groups of regulatory molecules during pregnancy against the background of chronic pyelonephritis. Сибирский научный медицинский журнал. 2023;43(6):210-214. (In Russ.) https://doi.org/10.18699/SSMJ20230626
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