A systematic review of the pharmacological effects of the active ingredients of blood-red hawthorn in cardiovascular diseases
https://doi.org/10.18699/SSMJ20230505
Abstract
Cardiovascular disease is widespread at the present time, causing the disability of the population. The main risk factors are hyperlipoproteinemia, hypertension, hyperglycemia, etc. Blood-red hawthorn Crataegus sanguinea, a species of the genus Hawthorn (Crataegus) of the Rose family (Rosaceae) is a universal remedy for the prevention of diseases of the cardiovascular system. Hawthorn medications have antihypertensive, cardioprotective, cardiotonic, antiarrhythmic, mild diuretic, antispasmodic and sedative effects. At the same time, biologically active substances of hawthorn are non-toxic and do not have pronounced side effects with prolonged use. In this regard, it is important to study the mechanisms of pharmacological action of drugs based on this plant in order to prolong and improve the quality of life of the population.
About the Author
O. Sh. Atabaeva
Altai State Medical University of Minzdrav of Russia
Russian Federation
Russian Federation
656038, Barnaul, Lenin ave., 40
candidate of biological sciences
References
1. Kurkin V.A., Morozova T.V., Pravdivtseva O.E. Research on the development of a methodology for standardization of blood-red hawthorn leaves. Khimiya rastitel’nogo syr’ya = Chemistry of Plant Raw Material. 2017;3:169–173. [In Russian]. doi: 10.14258/jcprm.2017031286
2. Barnaulov O.D. Phytotherapy of patients with cardiovascular diseases. Saint-hPetersburg: Eco-vector, 2018. 271 p. [In Russian].
3. Morozova T.V., Kurkin V.A., Pravdivtseva O.E. Actual problems of raw materials chemical standardization of medicinal plants of the genus hawthorn Rataegus L. Farmatsiya i farmakologiya = Pharmacy and Pharmacology. 2018;6(2):104–120. [In Russian]. doi: 10.19163/2307-9266-2018-6-2-104-120
4. Morozova T.V. Pharmacognostic study of some species of the genus hawthorn (Crataegus L.): dis. ... candidate of pharmaceutical sciences. Samara, 2019. [In Russian].
5. Rodionova T.V., Hishova O.M. Standardization of hawthorn leaves. Vestnik farmatsii = Bulletin of Pharmacy. 2008;(2):70–79. [In Russian].
6. Samylina I.A., Sorokina A.A., Pyatigorskaya N.V. Hawthorn (Rataegus): options for medical use. Farmateka = Pharmateca. 2010; 202(8):83–85. [In Russian].
7. Arslan R., Bor Z., Bektas N., Meriçli A.H., Ozturk Y. Antithromboticeffects of ethanol extract of Crataegus orientalis in the carrageenaninduced mice tail thrombosis model. Thromb. Res. 2011;127(3):210–213. doi: 10.1016/j.thromres.2010.11.028
8. Bahri-Sahloul R., Ammar S., Fredj R.B., Saguem S., Grec S., Trotin F., Skhiri F.H. Polyphenol contents and antioxidant activities ofextracts from flowers. Pak. J. Biol. Sci. 2009;12(9):660–668. doi: 10.3923/pjbs.2009.660.668
9. Nazhand А., Lucarini М., Durazzo А., Zaccardelli M., Cristarella S., Souto S.B., Silva A.M., Severino P., Souto E.B., Santini A. Hawthorn (Crataegus spp.): an updated overview on its beneficial properties. Forests. 2020;11(5):564. doi: 10.3390/f11050564
10. Qi C., Zhong Z., Francisco H., Moses S., Sum C. Hawthorn. J. Clin. Pharmacol. 2002;42(6):605–612. doi: 10.1177/00970002042006003
11. Rigelsky J.M., Sweet B.V. Hawthorn: Pharmacology and therapeutic uses. Am. J. Healt. Syst. Pharm. 2002;59(5):417–422. doi: 10.1093/ajhp/59.5.417
12. Trofimova S.V. Pharmacognostic study of the leaves of the blood-red hawthorn Crataegus sanguinea Pall. from the flora of Bashkortostan: abstract of thesis ... cand. pharmac. sci. Ufa, 2014. [In Russian].
13. Lesiovskaya E.E. Evidence-based phytotherapy: a guide for doctors and pharmacists. Saint-Petersburg: Fitotime, 2021. 275 p. [In Russian].
14. Walker A.F., Marakis G., Simpson E., Hope J.L., Robinson P.A., Hassanein M., Simpson H.C. Hypotensive effects of hawthorn forpatients with diabetes taking prescription drugs: a randomised controlled trial. Br. J. Gen. Pract. 2006;56(527):437–443.
15. Suleymanova S.V., Abakarov M.G., Khanakhmedova K.Sh., Mallaeva R.M. Pharmacological and pharmacotherapeutic properties of hawthorn (Crataegus oxycanha). Uspekhi sovremennoy nauki i obrazovaniya = Successes of Modern Science and Education. 2017;4(3):28-33. [In Russian].
16. Kuznetsova L.A., Basova N.E., Shpakov A.O. Neuronal nitric oxide synthases in the pathogenesis of metabolic syndrome. Sibirskij nauchnyj medicinskij zhurnal = Siberian Scientific Medical Journal. 2022;42(4):33–48. [In Russian]. doi: 10.18699/SSMJ20220403
17. Prokofiev I.I. The role of the nitric oxide system in the cardioprotective effect of neuroactive amino acid derivatives: abstract of thesis … сand. мed. sci. Volgograd, 2017. [In Russian].
18. Ebrahimzadeh M.A., Bahramian F. Antioxidant activity of Crataegus pentaegyna subsp. elburensis fruits extracts used in traditional medicine in Iran. Pak. J. Biol. Sci. 2009;12(5):413–419. doi: 10.3923/pjbs.2009.413.419
19. Kuznetsova V.L., Solovieva A.G. Nitric oxide: properties, biological role, mechanisms of action. Sovremennye problemy nauki i obrazovaniya = Modern Problems of Science and Education. 2015;4:462. [In Russian].
20. Tsydendambayev P.B., Khyshiktuev S.M., Nikolaev S.M. Biological effects of flavonoids. Byulleten’ Vostochno-Sibirskogo nauchnogo tsentra Sibirskogo otdeleniya Rossiyskoy akademii meditsinskikh nauk = Bulletin of East Siberian Scientific Center of Siberian Branch of Russian Academy of Medical Sciences. 2006;(6):229–232. [In Russian].
21. Arkhipov V.V. Clinical pharmacology of phosphodiesterase inhibitors. Prakticheskaya pul’monologiya = Practical Pulmonology. 2014;(3):35– 41. [In Russian].
22. Bailey J., Ollis D. Fundamentals of biochemical engineering. Moscow: Mir, 1989. 1282 p. [In Russian].
23. Miller A.L. Botanical influences on cardiovascular disease. Altern. Med. Rev.1998;3(6):422–431.
24. Walker A.F., Marakis G., Morris A.P., Robinson P.A. Promising hypotensive effect of hawthorn extract: A randomized double-blind pilot study of mild, essential hypertension. Phytother. Res. 2002;16(1):48– 54. doi: 10.1002/ptr.947
25. Cui T., Nakamura K., Tian S., Kayahara H., Tian Y.L. Polyphenolic content and physiological activities of Chinese hawthorn extracts. Biosci. Biotechnol. Biochem. 2006;70(2):2948–2956. doi: 10.1271/bbb.60361
26. Miller L.G. Herbal medicinals: selected clinical considerations focusing on known or potential drug-herb interactions. Arch. Intern. Med. 1998;158(20):2200– 2211. doi: 10.1001/archinte.158.20.2200
27. Schussler M., Holzl J., Ramp A.F., Fricke U. Functional and antiischaemic effects of Monoacetyl-vitexinrhamnoside in different in vitro models. Gen. Pharmacol. 1995;26(7):1565–1570. doi: 10.1016/03063623(95)00051-8.
28. Khutkina G.A. Emploiment of preparations of hawthorn (crataegus) in medicine. Vestnik farmatsii = Bulletin of Pharmacy. 2004;(2):22–27. [In Russian].
29. Kurkin V.A., Zaitseva E.N., Morozova T.V., Pravdivtseva O.E., Dubishchev A.V., Kurkina A.V., Avdeeva E.V., Agapov A.I., Belousov M.V. The study of the Crataegus sanguinea Pall. extractsdiuretic and antidepressant action. Byulleten’ sibirskoy meditsiny = Bulletin of Siberian Medicine. 2018;17(4):65-71. [In Russian]. doi: 10.20538/1682-0363-2018-4-65–71
30. Morozova T.V., Kurkin V.A., Kurkina A.V., Pravdivtseva O.E., Dubishchev A.V., Zaitseva E.N. Pharmacological and pharmacognostic study of raw hawthorn. Izvestiya Samarskogo nauchnogo tsentra Rossiyskoy akademii nauk = Proceedings of the Samara Scientific Center of the Russian Academy of Sciences. 2015;5(3):959–963. [In Russian].
31. Tarakhovsky Yu.S., Kim Yu.A., Abdrasilov B.S., Muzafarov E.N. Flavonoids: biochemistry, biophysics, medicine. Pushchino: Sunchrobook, 2013. 310 p. [In Russian].
32. Aguirre-Hernandez E., Gonzalez-Trujano M.E., Martinez A.L., Moreno J., Kite G., Terrazas T., SotoHernandez M. HPLC/MS analysis and anxiolytic-like effect of quercetin and kaempferol flavonoids from Tilia americana var. Mexicana. J. Ethnopharmacol. 2010;127(1):91–97. doi: 10.1016/j.jep.2009.09.044
33. Kurkin V.A., Kurkina A.V., Zaitseva E.N., Dubishchev A.V., Pravdivtseva O.E., Morozova T.V. Neurotropic and diuretic activity of thick extract of the blood-red hawthorn’s fruits. Byulleten’ sibirskoy meditsiny = Bulletin of Siberian Medicine. 2015.14(3):18– 22. [In Russian].
34. Lim D.W., Han T., Jung J., Song Y., Um M.Y., Yoon M., Kim Y.T., Cho S., Kim I.H., Han D., Lee C., Lee J. Chlorogenic acid from hawthorn berry (Crataegus pinnatifida fruit) prevents stress hormoneinduced depressive behavior, through monoamine oxidase B-reactive oxygen species signaling in hippocampal astrocytes of mice. Mol. Nutr. Food Res. 2018;62(15):e1800029. doi: 10.1002/mnfr.201800029
35. Deev R.V., Telesheva I.B., Sinitsky A.I., Agletdinov E.F., Nurgaleeva E.A. Changes in the catalytic specificity of monoamine oxidases of the liver in experimental modeling of post-traumatic stress disorder. Fundamental’nye issledovaniya = Fundamental Research. 2014;10(8):1485–1489. [In Russian].
36. Krishna A., San L., Valderrabano M., Palejd F.T., Klark D.U. Modeling CICR in rat ventricular myocytes: voltage clamp studies. Theor. Biol. Med. Model. 2010;7:43. doi: 10.1186/1742-4682-7-43
37. Weiss R.F., Fintelman F. Phytotherapy: manual. Moscow: Meditsina, 2004. 552 p. [In Russian].
38. Slepneva L.V., Khmylova G.A. Failure mechanism of energy metabolism during hypoxia and possible ways to correction of fumaratecontaining solutions. Transfuziologiya = Transfusiology. 2013;14(2):49–65. [In Russian].
39. Svishchenko E.P., Mishchenko L.A. Phytotherapy of arterial hypertension from the standpoint of evidence-based medicine. Kiev: Morion, 2009. 112 p. [In Russian].
40. Khishova O.M., Kravchenko E.V., Rodionova T.V. Pharmacological action of blood-red hawthorn and its use in medicine. Vestnik farmacii = Bulletin of Pharmacy. 2004;2(24):69–76. [In Russian].
41. Baklykova O.B., Sizova Zh.M., Shikh E.V. Possible use of standardized crataegus sanguinea extract in correction of cardiac phythm impairment in patients with chronic heart failure. Antibiotiki i himioterapiya = Antibiotics and Chemotherapy. 2009;54: (1-2):47–52. [In Russian].
42. Chervyakovsky E.M., Kurchenko V.P., Kostyuk V.A. The role of flavonoids in biological reactions with electron transfer. Trudy Belorusskogo gosudarstvennogo universiteta. Seriya: Fiziologicheskiye, biokhimicheskiye i molekulyarnyye osnovy funktsionirovaniya biosistem = Proceedings of the Belarusian State University. Series of Physiological, Biochemical and Molecular Biology Sciences. 2009;4(1):9–26. [In Russian].
43. Zverev Ya.F., Bryukhanov V.M. Flavonoids as advanced natural antioxidants. Byulleten’ meditsinskoy nauki = Bulletin of Medical Science. 2017;1(5):20–27. [In Russian].
44. Zverev Ya.F. Flavonoids through the eyes of a pharmacologist. Antioxidant and anti-inflammatory activity. Obzory po klinicheskoy farmakologii i lekarstvennoy terapii = Reviews on Clinical Pharmacology and Drug Therapy. 2017;15(4):5–13. [In Russian].
45. Zenkov N.K., Kolpakov A.R., Menshchikova E.B. Keap1/Nrf2/ARE redox-sensitive system as a phagmacological target in cardiovascular diseases. Sibirskij nauchnyj medicinskij zhurnal = Siberian Scientific Medical Journal. 2015;35(5):5–24. [In Russian].
46. Zverev Ya.F. Antiplatelet activity of flavonoids. Voprosy pitaniya = Problems of Nutrition. 2017;86(6):6–20. [In Russian].
47. Cloud A.M.E., Vilcins D., McEwen B.J. The effect of hawthorn (Crataegus spp.) on blood pressure: A systematic review. Adv. Integr. Med. 2019;7(3):167– 175. doi: 10.1016/j.aimed.2019.09.002
48. Akila M., Devaraj H. Synergistic effect of tincture of Crataegus and Mangifera indica L. extract on hyperlipidemic and antioxidant status inatherogenic rats. Vascul. Pharmacol. 2008;49(4-6):173–177. doi: 10.1016/j.vph.2008.07.007
49. Yao S., Sang H., Song G., Yang N., Liu Q., Zhang Y., Jiao P., Zong C., Qin S. Quercetin protects macrophages from oxidized low-density lipoproteininduced apoptosis by inhibiting the endoplasmic reticulum stressC/EBP homologous protein pathway. Exp. Biol. Med. (Maywood). 2012;237(7):822–831. doi: 10.1258/ebm.2012.012027
50. Tsybulkin N.A., Tukhvatullina G.V., Tsybulkina V.N., Abdrakhmanova A.I. Inflammatory mechanisms in pathogenesis of atherosclerosis. Prakticheskaya meditsina = Practical Medicine. 2016;96(42):165–169. [In Russian].
51. Pisarev D.I., Novikov O.O., Selyutin O.A., Pisareva N.A. Biological activity of plant polyphenols. The prospect of using anthocyanins in medical practice. Nauchnyye vedomosti Belgorodskogo gosudarstvennogo universiteta. Seriya: Meditsina. Farmatsiya = Scientific Statements of Belgorod State University. Series: Medicine. Pharmacy. 2012;129(10-2):17–24. [In Russian].
52. Jafarova R.E., Garaev G.Sh., Jafarkulieva Z.S. The effect of hawthorn flower extract on the course of diabetes mellitus in an experiment. Aktual’nye problemy gumanitarnyh i estestvennyh nauk = Actual Problems of Humanities and Natural Sciences. 2011;(4):284–288. [In Russian].
53. Korotko G.F. Postprandial of pancreatic serecia. Zhurnal fundamental’noy meditsiny i biologii = Journal of Basic Medicine and Biology. 2016;(2):4–15. [In Russian].
54. Chekina N.A. Flavonoids in the treatment of diabetes mellitus. Molodoy uchenyy = Young Scientist. 2010;(6):369–373. [In Russian].
55. Drapkina O.M. Atherosclerosis – liver disease. Consilium Medicum. 2015;17(12):13–14. [In Russian].
Review
For citations:
Atabaeva O.Sh. A systematic review of the pharmacological effects of the active ingredients of blood-red hawthorn in cardiovascular diseases. Сибирский научный медицинский журнал. 2023;43(5):50-61. (In Russ.) https://doi.org/10.18699/SSMJ20230505
Views:
1401
Email this article 