INFECTIOUS DISEASES IN HEMATOLOGIST’S PRACTICE: VISCERAL LEYSHMANIASIS IN HIV-INFECTED PATIENT
https://doi.org/10.15372/SSMJ20190110
Abstract
The clinical case of visceral leishmaniasis and HIV coinfection, associated with bone marrow involvement, which is uncommon in Siberia, was demonstrated. The detailed literature review on the issue was given. The data analysis of leishmaniasis prevalence dynamics in northern latitudes was conducted and the features of disease epidemiology were highlighted. The clinical forms of this parasite invasion and the contemporary ideas about mechanism of lieshmania escape from phagocytosis were described on the basis of recent data. The algorithm of differential diagnosis, diagnosis criterions and treatment standards were developed. The comprehensive approach to diagnosis and management of the zoonosis and HIV coinfection were described. The disease hematological features such as pancytopenia, lymphadenopathy, hepatosplenomegaly and fever were revealed. The significant of bone marrow hematopoiesis examination in leishmaniasis was specified. The analysis of the literature on the transformation of modern visceral leishmaniasis was carried out: an increase in the number of erased clinical debut forms, an increase in the duration of the latent period of the disease up to 130–160 days after transfection, an increase in the role of immunodepression factors in the clinical manifestation of the disease. The data on the epidemiological sources of zoonosis - insect vectors, conditions of infection, methods of prevention have been performed.
About the Authors
Yu. N. Obgolts
City Hematological Center
Russian Federation
Russian Federation
Yuliya Nikolaevna OBGOLTS – hematologist
630051, Novosibirsk, Polzunov str., 21
N. G. Samoylova
City Clinical Hospital No. 2
Russian Federation
Russian Federation
Natalya Grigorievna SAMOYLOVA – laboratory doctor
630051, Novosibirsk, Polzunov str., 21
S. S. Fed’
City Clinical Hospital No. 2
Russian Federation
Russian Federation
Fed’ S.S. – head of laboratory
630051, Novosibirsk, Polzunov str., 21
S. А. Karmanovskaya
City Clinical Hospital No. 2
Russian Federation
Russian Federation
Svetlana Aleksandrovna KARMANOVSKAYA – doctor of medical sciences, head of polyclinic department
630051, Novosibirsk, Polzunov str., 21
I. B. Kovynev
Novosibirsk State Medical University of Minzdrav of Russia
Russian Federation
Russian Federation
Igor Borisovich KOVYNEV – doctor of medical sciences, associate professor of the department of therapy, hematology and transfusiology
630091, Novosibirsk, Krasny av., 52
T. I. Pospelova
Novosibirsk State Medical University of Minzdrav of Russia
Russian Federation
Russian Federation
Tatyana Ivanovna POSPELOVA – doctor of medical sciences, professor, vice rector on scientific work, head of the department of therapy, hematology and transfusiology
630091, Novosibirsk, Krasny av., 52
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Review
For citations:
Obgolts Yu.N., Samoylova N.G., Fed’ S.S., Karmanovskaya S.А., Kovynev I.B., Pospelova T.I. INFECTIOUS DISEASES IN HEMATOLOGIST’S PRACTICE: VISCERAL LEYSHMANIASIS IN HIV-INFECTED PATIENT. Сибирский научный медицинский журнал. 2019;39(1):72-76. (In Russ.) https://doi.org/10.15372/SSMJ20190110
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