Мезенхимные стволовые клетки: свойства и клиническое применение
https://doi.org/10.18699/SSMJ20230204
Аннотация
Мезенхимные стволовые клетки (МСК) – это мультипотентные стромальные клетки, способные дифференцироваться в различные типы клеток, включая адипоциты, остеоциты, хондроциты и др. МСК могут быть выделены из различных тканей организма человека и животных. МСК характеризуются высокой пролиферативной способностью, дифференцировкой в соединительнотканном направлении, паракринной и трофической активностью (продуцируют широкий спектр биологически активных молекул), способны мигрировать в зону повреждения органов и тканей, оказывают иммуносупрессивное действие. Между МСК человека и млекопитающих имеются сходства и различия по фенотипу, функциональной активности. На экспериментальных моделях и в клинических испытаниях показан их терапевтический потенциал, что позволяет рассматривать МСК-ориентированные клеточные технологии как альтернативу традиционным способам лечения. В статье представлен обзор и анализ данных литературы, посвященной изучению свойств МСК, сигнальных путей, вовлеченных в регуляцию активности клеток, перспектив использования МСК в лечении воспалительно-дегенеративных заболеваний. В ходе подготовки обзора из баз данных eLibrary и Национального центра биотехнологической информации (NCBI) взяты полнотекстовые, свободного доступа статьи за период с 2006 по 2022 г.
Ключевые слова
Об авторе
А. П. Лыков
Новосибирский НИИ туберкулеза Минздрава России
Россия
Россия
Лыков Александр Петрович, к.м.н.
630040, г. Новосибирск, ул. Охотская, 81а
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Рецензия
Для цитирования:
Лыков А.П. Мезенхимные стволовые клетки: свойства и клиническое применение. Сибирский научный медицинский журнал. 2023;43(2):40-53. https://doi.org/10.18699/SSMJ20230204
For citation:
Lykov A.P. Mesenchymal stem cells: properties and clinical application. Сибирский научный медицинский журнал. 2023;43(2):40-53. (In Russ.) https://doi.org/10.18699/SSMJ20230204
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