PROSPECTS FOR THE USE OF NATURAL ALKYL-GLYCEROLS IN TARGETED THERAPY OF BRONCHIAL ASTHMA ASSOCIATED WITH OBESITY (REVIEW)
https://doi.org/10.15372/SSMJ20180615
Abstract
There are relevant areas of research aimed at studying the mechanisms of development and optimization of therapeutic approaches to hard controllable phenotypes of bronchial asthma in the disease prevention and treatment. This is the phenotype of bronchial asthma associated with obesity. The central function in the lungs physiology and pathology as well as in the obesity etiopathogenesis is assigned to lipids, which play a crucial role in maintaining the cell energy balance and the implementation of intracellular and intercellular signalization. Detailization of the role of alkyl-glycerols structure metabolites in the mechanisms of formation of the bronchial asthma phenotype in combination with obesity is an important area of modern research. In the analysis of modern studies on this problem, the strategy of treatment of bronchial asthma associated with obesity based on the General mechanisms of metabolic and signal disorders in these diseases was identified and justified. In recent years, due to the discovery of the relationship of disorders in the biosynthesis of diacyl and alk(en)yl acyl phospholipids with respiratory diseases and obesity, there is a growing interest in their study as promising therapeutic targets. The introduction of anti-inflammatory natural compounds, which include alkyl-glycerols contained in marine hydrobionts, will modify the intracellular signaling pathways responsible for inflammatory cell activation in bronchial asthma associated with obesity.
About the Authors
T. P. Novgorodtseva
Vladivostok Branch of Far Eastern Scientific Center of Physiology of Respiration - Research Institute of Medical Climatology and Rehabilitation Treatment
Russian Federation
Russian Federation
O. Y. Kytikova
Vladivostok Branch of Far Eastern Scientific Center of Physiology of Respiration - Research Institute of Medical Climatology and Rehabilitation Treatment
Russian Federation
Russian Federation
T. A. Gvozdenko
Vladivostok Branch of Far Eastern Scientific Center of Physiology of Respiration - Research Institute of Medical Climatology and Rehabilitation Treatment
Russian Federation
Russian Federation
M. V. Antonyuk
Vladivostok Branch of Far Eastern Scientific Center of Physiology of Respiration - Research Institute of Medical Climatology and Rehabilitation Treatment; Far Eastern Federal University
Russian Federation
Russian Federation
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