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CLINICAL AND LABORATORY CHARACTERISTICS OF CHRONIC CYSTITIS IN WOMEN OF DIFFERENT AGE GROUPS

https://doi.org/10.15372/SSMJ20180612

Abstract

The study included 348 women with chronic cystitis who were divided into 3 age groups: Group 1 - 20 to 39 years old; Group 2 - 40 to 59 years old; Group 3 - elderly age (60 years and older). Bacterial flora was detected for the total sample in 35.3 % of patients without significant differences between age groups. The results indicate that infection is not the only cause affecting the development and persistence of chronic inflammation of the bladder. The incidences of leukoplakia of the bladder in age groups 1, 2 and 3 were 71 %, 50 % and 11 %, respectively. The survey results revealed increasing severity of symptoms such as pelvic pain and urination disorders with age. The evaluation of urination diaries revealed a decrease in the bladder effective volume with age and an increase in urination frequency in the daytime and at night. A significant increase in symptoms in the presence of leukoplakia was also revealed. High incidence of squamous metaplasia and leukoplakia and increased frequency of exacerbations of cystitis in young women may be associated with the catatoxic, highly reactive type of response of the transitional epithelium of the bladder. Increasing symptoms such as urinary disorders in older women with chronic cystitis may be caused by an adverse effect of systemic metabolic factors of the disease pathogenesis.

About the Authors

K. G. Notov
Research Institute for Experimental and Clinical Medicine, Federal Research Center for Fundamental and Translational Medicine; Novosibirsk State Medical University of Minzdrav of Russia; Railway Clinical Hospital at Novosibirsk Main Railway Station
Russian Federation


E. G. Novikova
Research Institute for Experimental and Clinical Medicine, Federal Research Center for Fundamental and Translational Medicine
Russian Federation


I. V. Feofilov
Novosibirsk State Medical University of Minzdrav of Russia
Russian Federation


A. A. Erkovich
Novosibirsk State Medical University of Minzdrav of Russia; Railway Clinical Hospital at Novosibirsk Main Railway Station
Russian Federation


F. A. Sevryukov
Railway Clinical Hospital at Nizhny Novgorod Railway Station
Russian Federation


L. P. Plutalova
Railway Clinical Hospital at Novosibirsk Main Railway Station
Russian Federation


I. M. Mitrofanov
Research Institute for Experimental and Clinical Medicine, Federal Research Center for Fundamental and Translational Medicine; Novosibirsk State Medical University of Minzdrav of Russia
Russian Federation


V. G. Selyatitskaya
Research Institute for Experimental and Clinical Medicine, Federal Research Center for Fundamental and Translational Medicine
Russian Federation


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ISSN 2410-2512 (Print)
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