Anabolic activity of leuzea and cranberry meal plant extracts composition
https://doi.org/10.18699/SSMJ20210604
Abstract
Еhe anabolic properties of a new composition of leuzea and cranberry meal extracts in a ratio of 7:50, containing ecdisten and ursolic acid, respectively, have been investigates on a model of isolated overload of the skeletal muscle of the rats leg by the method of excision. Material and methods. The experiment was conducted on Wistar stock rats of both sexes weighing 220–250 g. At the beginning of the experiment, all animals underwent musculus gastrocnemius tenotomy (m.gastrocnemius), and then the composition has been intragastrically administered for 14 days. At the end of the experiment, the rats were decapitated, blood was taken to determine biochemical parameters (creatine phosphokinase activity, glucose and lactate level) and muscles from both legs were separated to determine the difference between the mass of the musculus soleus (m. soleus) operated on and the mass m.soleus of a non-operated paw. Results and discussion. A dose-dependent anabolic effect was established for the composition of leuzea and cranberry meal extracts. A gender difference was found, which was confirmed by the obtained values of creatine phosphokinase activity and glucose/lactate ratio. Conclusions. The composition of leuzea and cranberry meal extracts exhibits a dose-dependent anabolic effect in males and increase physical endurance in female rats on the model of isolated overload of the skeletal muscle of the leg of rats with tenotomy operation.
Supporting agencies: The work was carried out as part of the implementation of the State task of the VIOC SB RAS № АААА-А21-121011490015-1.
About the Authors
D. A. Khalikova
Vorozhtzov Institute of Organic Chemistry of Siberian Branch of the Russian Academy of Science
Russian Federation
Russian Federation
Daria A. Khalikova
630090, Novosibirsk, Academician Lavrentiev ave., 9
S. V. Ankov
Vorozhtzov Institute of Organic Chemistry of Siberian Branch of the Russian Academy of Science
Russian Federation
Russian Federation
Sergey V. Ankov, candidate of biological sciences
630090, Novosibirsk, Academician Lavrentiev ave., 9
J. V. Meshkova
Vorozhtzov Institute of Organic Chemistry of Siberian Branch of the Russian Academy of Science
Russian Federation
Russian Federation
Julia V. Meshkova
630090, Novosibirsk, Academician Lavrentiev ave., 9
T. G. Tolstikova
Vorozhtzov Institute of Organic Chemistry of Siberian Branch of the Russian Academy of Science
Russian Federation
Russian Federation
Tatiana G. Tolstikova, doctor of biological sciences, professor
630090, Novosibirsk, Academician Lavrentiev ave., 9
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