Особенности состояния эндотелия при Ph-негативных миелопролиферативных новообразованиях
https://doi.org/10.18699/SSMJ20210603
Аннотация
Тромботические осложнения вносят существенный вклад в тяжесть течения заболевания и смертность при Phнегативных миелопролиферативных новообразованиях (МПН), включая истинную полицитемию, эссенциальную тромбоцитемию и первичный миелофиброз. Сосудистый эндотелий является неотъемлемым компонентом системы гемостаза, нарушение функциональности которого играет важную роль в развитии протромботических состояний. В обзоре приведен анализ имеющихся данных литературы по оценке особенностей эндотелия при Ph-негативных МПН и их выявлению при помощи различных методов. Поиск литературных источников проводили с использованием баз данных PubMed и eLibrary. Анализ результатов исследований с применением различных методов оценки свидетельствует, что для пациентов с Ph-негативными МПН характерны активация, повреждение и, следовательно, дисфункция эндотелия. Ассоциированные с миелопролиферацией нарушения эндотелия отражаются на реализации всех его функций. Эндотелиальная дисфункция является важным патогенетическим звеном развития тромботических осложнений при Ph-негативных МПН.
Об авторе
Н. Е. Корсакова
Российский НИИ гематологии и трансфузиологии ФМБА России
Россия
Россия
Наталья Евгеньевна Корсакова
191024, г. Санкт-Петербург, ул. 2-я Советская, 16
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