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Основные направления и перспективы в терапии синдрома поликистоза яичников

https://doi.org/10.18699/SSMJ20210602

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Аннотация

Статья посвящена актуальной гинекологической проблеме женщин репродуктивного возраста – синдрому поликистоза яичников (СПКЯ) и возможностям его фармакотерапии. Сложность в выборе фармакотерапии заболевания заключается в том, что необходимо учитывать все его клинические проявления, не ограничиваясь нарушениями менструального цикла и бесплодием. СПКЯ сопровождается, как правило, гирсутизмом, ожирением, снижением толерантности к глюкозе и другими проявлениями в различных системах органов, связанных с метаболическими нарушениями. Эти проявления существенно снижают качество жизни пациенток и также требуют фармакологической коррекции. В настоящее время первой линией препаратов в лечении СПКЯ остаются комбинированные оральные контрацептивы (КОК), которые используются женщинами уже на протяжении десятков лет, но обладают множественными нежелательными реакциями. Последнее служит поводом для поиска других методов фармакотерапии, обладающих высокой эффективностью и безопасностью. Одним из таких препаратов является пероральный сахароснижающий препарат метформин, доказавший свою эффективность в лечении СПКЯ. На стадии исследования находятся агонисты рецепторов глюкагоноподобного пептида-1, продолжается разработка тактики лечения СПКЯ с использованием сахароснижающих препаратов, обладающих антагонизмом к глюкагону. Расширение возможности выбора фармакотерапии, благодаря поиску новых более эффективных и безопасных лекарственных средств, и сочетание ее с другими методами лечения делают возможным контроль над СПКЯ с учетом индивидуальных особенностей пациенток.

Об авторах

А. Н. Усеинова
Крымский федеральный университет им. В.И. Вернадского
Россия

Асие Наримановна Усеинова, к.м.н. 

295051, г. Симферополь, бульв. Ленина, 5/7



Е. А. Егорова
Крымский федеральный университет им. В.И. Вернадского
Россия

Елена Александровна Егорова, к.фарм.н.

295051, г. Симферополь, бульв. Ленина, 5/7



Е. А. Елишева
Крымский федеральный университет им. В.И. Вернадского
Россия

Екатерина Александровна Елишева

295051, г. Симферополь, бульв. Ленина, 5/7



А. М. Бейтуллаев
Крымский федеральный университет им. В.И. Вернадского
Россия

Асан Марленович Бейтуллаев 

295051, г. Симферополь, бульв. Ленина, 5/7



К. Н. Корянова
Пятигорский медико-фармацевтический институт – филиал Волгоградского государственного медицинского университета Минздрава России
Россия

Ксения Николаевна Корянова, к.фарм.н.

357532, г. Пятигорск, пр. Калинина, 11



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Рецензия

Для цитирования:


Усеинова А.Н., Егорова Е.А., Елишева Е.А., Бейтуллаев А.М., Корянова К.Н. Основные направления и перспективы в терапии синдрома поликистоза яичников. Сибирский научный медицинский журнал. 2021;41(6):18-29. https://doi.org/10.18699/SSMJ20210602

For citation:


Useinova A.N., Egorova E.A., Yelisheva E.A., Beitullaev А.М., Koryanova K.N. The main directions and prospects in polycystic ovary syndrome treatment. Siberian Scientific Medical Journal. 2021;41(6):18-29. (In Russ.) https://doi.org/10.18699/SSMJ20210602

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