Current views on the role of fatty acids in the diagnosis of cardiovascular diseases (review)
https://doi.org/10.18699/SSMJ20210401
Abstract
An additional informative tool in the diagnosis of cardiovascular diseases in the early stages can be the analysis of changes in the fatty acid profile, which can be considered as a marker of various pathological conditions. The study of the effects of fatty acids and the mechanisms of changes in the fatty acid profile in connection with cardiovascular diseases remains relevant. We have analyzed modern data from foreign and domestic literature on issues related to the importance of fatty acids as possible markers in the diagnosis of cardiovascular diseases. Basic information about the structure of fatty acids, their functions in the human body, the relationship between the level of free fatty acids and indicators of the development of pathological processes of the cardiovascular system is presented. The factors influencing the dynamics of fatty acid concentrations both in normal conditions and during the development of pathological processes are reflected. The processes of biochemical modification of the fatty acid composition of the lipid matrix of the cell membrane are considered. The expediency of using fatty acids, together with some protein markers in the diagnosis of diseases of the cardiovascular system, has been shown. The collection and analysis of the accumulated information on the role of fatty acids helps to optimize the use of laboratory markers to determine the stages of pathogenesis of circulatory organ damage, to develop a system for evaluating the effectiveness of therapy for cardiovascular diseases, and to create a set of laboratory and instrumental tests for monitoring the condition of patients.
About the Authors
O. V. Astafyeva
Astrakhan State Medical University of Minzdrav of Russia
Russian Federation
Russian Federation
Oxana V. Astafyeva, candidate of biological science
414000, Astrakhan, Bakinskaya str., 121
Z. V. Zharkova
Astrakhan State Medical University of Minzdrav of Russia
Russian Federation
Russian Federation
Zinaida V. Zharkova
414000, Astrakhan, Bakinskaya str., 121
A. L. Yasenyavskaya
Astrakhan State Medical University of Minzdrav of Russia
Russian Federation
Russian Federation
Anna L. Yasenyavskaya, candidate of medical sciences
414000, Astrakhan, Bakinskaya str., 121
O. A. Bashkina
Astrakhan State Medical University of Minzdrav of Russia
Russian Federation
Russian Federation
Olga А. Bashkina, doctor of medical sciences, professor
414000, Astrakhan, Bakinskaya str., 121
M. A. Samotrueva
Astrakhan State Medical University of Minzdrav of Russia
Russian Federation
Russian Federation
Marina A. Samotrueva, doctor of medical sciences, professor
414000, Astrakhan, Bakinskaya str., 121
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