Possibilities of intravenous contrast-enhanced ultrasound in the diagnosis of prostate cancer
https://doi.org/10.18699/SSMJ20210209
Abstract
Aim of the study was to investigate the possibilities of contrast-enhanced ultrasound (CEUS) of the prostate gland in the diagnosis of malignant tumors by analyzing the shapes of the «time – intensity» curves. Material and methods. Sixty six patients with suspected prostate cancer were examined. According to CEUS data, the shapes of «time – intensity» curves were estimated with the selection of 4 types, the results were compared with the histology data. Results. For malignant focal changes in the pancreas, type I time-intensity curve was more often characteristic – a rapid increase in contrast from the first seconds, followed by rapid washout during the study (85 %). The sensitivity, specificity, and accuracy of this feature in the diagnosis of prostate cancer were 85, 89 and 86 %, respectively. Conclusion. Evaluation of the shape of the curve «time – intensity» during the CEUS of the prostate gland allows for differential diagnosis of focal changes in the prostate gland and determine the area for targeted biopsy.
Supporting agencies: The work was carried out with the charitable support of «Lukoil» – OOO «RITEK»
About the Authors
M. Z. Khasanov
Kazan State Medical Academy – Branch of Russian Medical Academy of Continuous Professional Education; Republican Clinical Oncological Dispensary of Minzdrav of the Republic of Tatarstan
Russian Federation
Russian Federation
Marat Z. Khasanov
420012, Kazan, Butlerova str., 36
420029, Kazan, Siberian path, 29
M. G. Tukhbatullin
Kazan State Medical Academy – Branch of Russian Medical Academy of Continuous Professional Education
Russian Federation
Russian Federation
Munir G. Tukhbatullin, doctor of medical sciences, professor
420012, Kazan, Butlerova str., 36
N. A. Savelyeva
Kazan State Medical Academy – Branch of Russian Medical Academy of Continuous Professional Education; Republican Clinical Oncological Dispensary of Minzdrav of the Republic of Tatarstan
Russian Federation
Russian Federation
Natalia A. Savelyeva, candidate of medical sciences
420012, Kazan, Butlerova str., 36
420029, Kazan, Siberian path, 29
V. A. Khachaturyan
Republican Clinical Oncological Dispensary of Minzdrav of the Republic of Tatarstan
Russian Federation
Russian Federation
Viktoria A. Khachaturyan
420029, Kazan, Siberian path, 29
References
1. Bray F., Ferlay J., Soerjomataram I., Siegel R.L., Torre L.A., Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 2018; 68 (6): 394–424. doi: 10.3322/caac.21492
2. Russo G., Mischi M., Scheepens W., de la Rosette J.J., Wijkstra H. Angiogenesis in prostate cancer: onset, progression and imaging. BJU Int. 2012; 110 (11): 794–808. doi: 10.1111/j.1464-410x.2012.11444.x
3. Postema A., Mischi M., de la Rosette J., Wijkstra H. Multiparametric ultrasound in the detection of prostate cancer: a systematic review. World J. Urology. 2015; 33 (11): 1651–1659. doi: 10.1007/s00345-015-1523-6
4. Хасанов М.З., Тухбатуллин М.Г. Мультипараметрическая ультразвуковая диагностика рака предстательной железы: обзор литературы. Поволж. онкол. вестн. 2018; 33 (1): 68–78. Khasanov M.Z., Tukhbatullin M.G. Multiparameter ultrasound diagnostics of prostate cancer: literature review. Povolzhskiy onkologicheskiy vestnik = Oncology Bulletin of the Volga Region. 2018; 33 (1): 68–78. [In Russian].
5. Sidhu P., Cantisani V., Dietrich C., Gilja O., Saftoiu A., Bartels E., Bertolotto M., Calliada F., Clevert D-A., Cosgrove D., Deganello A., D’Onofrio M., Drudi F.M., Freeman S., Harvey C., Jenssen C.,Jung E.-M., Klauser A.S., Lassau N., Meloni M.F., Leen E., Nicolau C., Nolsoe C., Piscaglia F., Prada F., Prosch H., Radzina M., Savelli L., Weskott H-P., Wijkstra H. The EFSUM B guidelines and recommendations for the clinical practice of ContrastEnhanced Ultrasound (CEUS) in non-hepatic applications: update 2017 (long version). Ultraschall. Med. 2017; 39 (2): 2–44. doi: 10.1055/a-0586-1107
6. Бусько Е.А., Мищенко А.В., Семиглазов В.В., Криворотько П.В., Зиновьев Г.В. Способ дифференциальной диагностики образований молочной железы и мягких тканей. Пат. 2634783 РФ; Опубл. 03.11.2017. Busko E.A., Mishchenko A.V., Semiglazov V.V., Krivorotko P.V., Zinoviev G.V. Method for differential diagnosis of breast and soft tissue formations. Patent 2634783 RF; published 03.11.2017. [In Russian].
7. Drudi F.M., di Leo N., Malpassini F., Antonini F., Corongiu E., Iori F. CEUS in the differentiation between low and high-grade bladder carcinoma. J. Ultrasound. 2012; 15 (4): 247–251. doi:10.1016/j.jus.2012.09.002
8. Seitz M., Gratzke C., Schlenker B., Buchner A., Karl A., Roosen A., Bernhard B.S., Patrick J.B., Süleyman E., Christian G.S., Reich O., Tilki D. Contrast-enhanced transrectal ultrasound (CETRUS) with cadence-contrast pulse sequence (CPS) technology for the identification of prostate cancer. Urol. Oncol. 2011; 29 (3): 295–301. doi:10.1016/j.urolonc.2009.03.032
9. Pierorazio P.M., Walsh P.C., Partin A.W., Epstein J.I. Prognostic Gleason grade grouping: data based on the modified Gleason scoring system. BJU Int. 2013; 111 (5): 753–760. doi:10.1111/j.1464-410x.2012.11611.x
10. Wilson N.M., Masoud A.M., Barsoum H.B., Refaat M.M., Moustafa M.I., Kamal T.A. Correlation of power Doppler with microvessel density in assessing prostate needle biopsy. Clin. Radiol. 2004; 59 (10): 946–950. doi:10.1016/j.crad.2004.03.021
11. Шатылко Т.В., Седова Л.Н., Королев А.Ю. Применение энергетической допплерографии при подозрении на рак предстательной железы. Вестн. урол. 2016; (3): 17–27. doi: 10.21886/2308-6424-2016-0-3-17-27 Shatylko T.V., Sedova L.N., Korolev A.Yu. Power Doppler imaging in patients with suspected prostate cancer. Vestnik urologii = Urology Bulletin. 2016; (3): 17–27. [In Russian]. doi: 10.21886/2308-6424-2016-0-3-17-27
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