APPLICATION OF PHYSICAL FACTORS TO REDUCE THE BARRIER FUNCTION OF EPIDERMIS FOR LASER RADIATION

Abstract

The purpose of the study is to determine the optimal technique for reducing the barrier function of skin epidermis to increase the laser radiation penetrating depth into tissues. Material and methods. The experiments were carried out with full-layer human skin samples obtained after surgical intervention. The source of laser radiation was placed on one side of the irradiated tissue and glass fiber was introduced coaxially with it on the other side to determine the depth of penetration of laser radiation into biological tissues. The radiation receiver was a photoelectric multiplier. The density of the light flux changed together with the change in the position of the fiber in the array of tissues., The depth of radiation penetration into the irradiated sample was determined after constructing the radiation intensity curve. The study of native preparations of human skin was carried out before and after exposure to physical factors. Methods of microdermabrasion, laser ablation of skin surface layers, ionophoresis and ultrasound were used to conduct the study in order to reduce the barrier function of skin epidermis. After these methods exposure, the depth of penetration of laser radiation into the tissue was measured during laser radiation with wavelengths of 532 and 1064 nm. Results and discussion. It has been established that microdermabrasion and laser ablation of epidermis stratum corneum reduced the absorption of laser radiation at the depth of up to 2.5 mm resulting in significant reducing the laser radiation power.