Dynamics of postsurgical wound local changes and healing rate during the use of alpha-glutamyl-tryptophan in combination therapy of patients with skin and soft-tissue infections

Skin and soft-tissue infections (SSTI) take the lead in surgical disorders. Changes of local and systemic immunoreactivity highlight the SSTI and hinder treatment due to disease chronicity. The immunotropic therapy could be the useful tool in SSTI treatment. The aim of the study was to assess the dynamics of local changes and and duration of wound healing during the use of alpha-glutamyl-tryptophan (AGT/Thymogen) in the combination therapy of SSTI patients. Material and methods. A sample of 77 individuals aged 18–55 years with moderate SSTI of different localization and with signs of infectious intoxication participated in the randomized, double-blind, parallel group, placebo-controlled clinical trial. The patients were divided into the main (39 people) and control (38 people) groups. The combination therapy of the main group included 100 μg of AGT by intramuscular injection daily during 7 days, whereas the control group received placebo (0,9 % sodium chloride) along the same schedule. Results and discussion. The combination therapy of SSTI patients with AGT significantly decreased the local inflammation, i.e. pain intensity, hyperemia, edema (p = 0,022), infiltration within damage area (p = 0,03). Besides, AGT treatment leads to statistically and clinically significant reduction in the duration of septic wound healing by an average of 2 days as compared to control group. Thus, statistically, and clinically significant superiority of efficacy of alpha-glutamyl-tryptophan in comparison with placebo in reducing the time of healing of purulent wounds of patients with SSTI has been established.

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