Витамин D (стероидный гормон) и заболевания нервной системы (обзор литературы)

Представлен обзор публикаций по витамину D, его роли в развитии и патогенезе хронических заболеваний нервной системы. Предмет: зависимость развития хронических заболеваний нервной системы от уровня витамина D. Методы: поиск статей в базе данных PubMed, а также через отечественные электронные ресурсы по тегам vitamin D (витамин D), brain diseases (заболевания головного мозга), chronic nervous system diseases (хронические заболевания нервной системы), Parkinson’s disease (болезнь Паркинсона), Alzheimer’s disease (болезнь Альцгеймера), multiple sclerosis (рассеянный склероз), schizophrenia (шизофрения). Результаты. Витамин D, будучи стероидным гормоном, оказывает стимулирующее влияние на мозговую активность как у эмбриона, так и у взрослого индивида; регулирует деятельность нейронных кругов, а также двигательное и эмоциональное поведение. Низкие уровни витамина D в плазме крови обнаружены у пациентов с болезнью Паркинсона, болезнью Альцгеймера, рассеянным склерозом, шизофренией, расстройством аутистического спектра и при нарушениях сна. Обсуждение. Данные представленных современных исследований противоречивы, необходимо дальнейшее изучение значимости гиповитаминоза витамина D для манифестации хронических заболеваний нервной системы и их прогрессирования, а также эффективности препаратов витамина D у пациентов с хронической патологией нервной системы.

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