Composition based on aluminum oxide and polydimethylsiloxane matrix for enhancing drug targeting
https://doi.org/10.15372/SSMJ20200205
Abstract
Methodological approaches developed at Research Institute of Clinical and Experimental Lymphology for a number of years allow formulating the importance of embedding active pharmaceutical ingredients (API) in the structure of porous carriers (sorbents). The composition of the carrier and API is an enteral system for prolonged dosing of pharmacological agents, which allows providing a specific pharmacological effect and safety of use. The pores of the media (sorbents) act as containers for API. This is especially important for rapidly absorbed drugs, which include, for example, lithium preparations that are used in narrow concentration limits due to their side effects. At the moment, an innovative technology for creating new medicines with an improved combination of efficiency and safety (pharmacological upgrade) has been developed and implemented. The essence of the technology is to create a composition of aluminum oxide and polydimethylsiloxane (matrix) and an active pharmacological ingredient (API). A study of two drugs based on matrix / lithium citrate and matrix / melatonin showed continued specific pharmacological activity of API, better pharmacokinetics, and better safety parameters. The matrix of aluminum oxide and polydimethylsiloxane provides an upgrade of the pharmacological properties of drugs for the dosed and safe delivery of API to the zone of their therapeutic effect.
About the Authors
M. A. Korolev
Research Institute of Clinical and Experimental Lymphology Branch of the Institute of Cytology and Genetics, SB RAS
Russian Federation
Russian Federation
Maksim A. Korolev, candidate of medical sciences
630060, Novosibirsk, Timakov str., 2
L. N. Rachkovskaya
Research Institute of Clinical and Experimental Lymphology Branch of the Institute of Cytology and Genetics, SB RAS
Russian Federation
Russian Federation
Lyubov N. Rachkovskaya, candidate of chemical sciences
630060, Novosibirsk, Timakov str., 2
V. I. Konenkov
Research Institute of Clinical and Experimental Lymphology Branch of the Institute of Cytology and Genetics, SB RAS
Russian Federation
Russian Federation
Vladimir I. Konenkov, doctor of medical sciences, professor, academician of RAS
630060, Novosibirsk, Timakov str., 2
A. Yu. Letyagin
Research Institute of Clinical and Experimental Lymphology Branch of the Institute of Cytology and Genetics, SB RAS
Russian Federation
Russian Federation
Andrey Yu. Letyagin, doctor of medical sciences, professor
630060, Novosibirsk, Timakov str., 2
P. G. Madonov
Research Institute of Clinical and Experimental Lymphology Branch of the Institute of Cytology and Genetics, SB RAS
Russian Federation
Russian Federation
Pavel G. Madonov, doctor of medical sciences, professor
630060, Novosibirsk, Timakov str., 2
References
1. Borodin Yu.I., Konenkov V.I., Parmon V.N., Lyubarsky M.S., Rachkovskaya L.N., Bgatova N.P., Letyagin A.Yu. Biological properties of sorbents and prospects for their application. Uspekhi sovremennoi biologii = Biology Bulletin Reviews. 2014; 134 (3): 236–248. [In Russian].
2. Borodin Yu.I., Rachkovskaya L.N., Darneva I.S., Novoselova T.I. Enterosorbent Noolit for physical and psychological rehabilitation. Novosibirsk: Sova, 2006. 220 p. [In Russian].
3. Konenkov V.I., Rachkovskaya L.N., Letyagin A.Yu., Suslov N.I., Shurlygina A.V., Robinson M.V., Korolev M.A., Kotlyarova A.A., Popova T.V., Rachkovsky E.E., Poveteva T.N., Shilova N.V., Nesterova Yu.V., Afanaseva O.G., Kulpin P.V. The influence of the complex of lithium citrate, polymethylsyloxane and aluminum oxide on conditional reflector behavior of intact mice and mice with caffeine and alcohol intoxication. Rossiyskiy fiziologicheskiy zhurnal imeni Ivana Mikhaylovicha Sechenova = Russian Journal of Physiology. 2017; 103 (10): 1125–1134. [In Russian].
4. Konenkov V.I., Rachkovskaya L.N., Letyagin A.Yu., Suslov N.I., Shurlygina A.V., Robinson M.V., Korolev M.A., Kotlyarova A.A., Popova T.V., Rachkovsky E.E., Poveteva T.N., Chilova I.V., Nesterova Yu.V., Afanaseva O.G., Kulpin P.V. Influence of a new drug based on a complex of lithium citrate, polymethylsiloxane and aluminum oxide on the adaptation of animals to physical activity, social adaptation and aggressive behavior. Eksperimental’naya i klinicheskaya farmakologiya = Experimental and Clinical Pharmacology. 2019; 82 (1): 3–7. [In Russian]. doi:10.30906/0869-2092-2019-82-1-3-7
5. Michurina S.V., Letyagin A.Yu., Shurlygina A.V., Korolev M.A., Ishchenko I.Yu., Vasendin D.V., Arkhipov S.A. Hepato-immuno-epiphyseal axis of intersystem interactions. Melatonin and structural and functional changes in the liver and immune system in obesity and type 2 diabetes. Novosibirsk: Manuscript, 2019. 300 р. [In Russian].
6. Socially significant diseases of the Russian population in 2018 (Statistical materials). Moscow, 2019. 37 p. https://www.rosminzdrav.ru/ministry/61/22/stranitsa-979/statisticheskie-i-informatsionnye-materialy/statisticheskiy-sbornik-2018-god [In Russian]
7. Сhukin G.D. Structure of aluminum oxide and hydrodesulfurization catalysts. Reaction mechanism. Moscow: Printa, 2010. 288 p. [In Russian].
8. Epidemiological indicators and indicators of psychiatric services in the Russian Federation (20052013). Statistical reference book. Moscow, 2015. 570 p. [In Russian]
9. Öhlund L. Ott M., Oja S., Bergqvist M., Lundqvist R., Sandlund M., Salander Renberg Е., Werneke U. Reasons for lithium discontinuation in men and women with bipolar disorder: a retrospective cohort study. BMC Psychiatry. 2018; 18 (1): 37. doi: 10.1186/s12888-018-1622-1
10. Post R.M. The new news about lithium: an underutilized treatment in the United States. Neuropsychopharmacology. 2018; 43 (5): 1174–1179. doi:10.1038/npp.2017.238
11. Rybakowski J.K. Challenging the Negative Perception of Lithium and Optimizing Its Long-Term Administration. Front. Mol. Neurosci. 2018; (11): 349. doi: 10.3389/fnmol.2018.00349
12. World Health Organization. ICD-11 for mortality and morbidity statistics: Bipolar or related disorders. https://icd.who.int/browse11/l-m/en
Review
For citations:
Korolev M.A., Rachkovskaya L.N., Konenkov V.I., Letyagin A.Yu., Madonov P.G. Composition based on aluminum oxide and polydimethylsiloxane matrix for enhancing drug targeting. Сибирский научный медицинский журнал. 2020;40(2):40-46. (In Russ.) https://doi.org/10.15372/SSMJ20200205
Views:
291
Email this article 