Morphological disturbances of rat parietal cortex and hippocampus neurons in the dynamics steady subtotal ischemia of the brain
https://doi.org/10.15372/SSMJ20200204
Abstract
The purpose of the work is to analyze changes in the morphological characteristics of neurons of phylogenetical different parts of the cerebral cortex (parietal cortex and hippocampus) of rats at different periods in the dynamics of stepwise subtotal experimental cerebral ischemia. Methods. The experiments were performed on 42 males of outbred white rats. Step subtotal cerebral ischemia was performed as follows: first, one common carotid artery was ligated, simulating partial ischemia. Then, with an interval of 1 day (subgroup 1), 3 days (subgroup 2) or 7 days (subgroup 3), the second common carotid artery was ligated. Results. A microscopic study of the size, shape, degree of chromatophilia of the cytoplasm and the content of ribonucleoproteins in pyramidal neurons of phylogenetically different parts of the cerebral cortex have shown the dependence of the severity of brain damage on the interval between the cessation of blood flow in both carotid artery. Adaptation was better with a 7-day interval between dressings, while the ligation with an interval of 1 day, the degree of morphological changes was maximum indicating a lack of resources for the implementation of adaptation mechanisms.
About the Authors
E. I. Bon
Grodno State Medical University
Belarus
Belarus
Elizaveta I. Bon, candidate of biological science
230009, Grodno, Gorkogo str., 80
N. E. Maksimovich
Grodno State Medical University
Belarus
Belarus
Natalia E. Maksimovich, doctor of medical science, professor
230009, Grodno, Gorkogo str., 80
S. M. Zimatkin
Grodno State Medical University
Belarus
Belarus
Sergey M. Zimatkin, doctor of biological science, professor
230009, Grodno, Gorkogo str., 80
N. A. Valko
Grodno State Medical University
Belarus
Belarus
Nikita A. Valko
230009, Grodno, Gorkogo str., 80
V. N. Kot
Grodno State Medical University
Belarus
Belarus
Victoria N. Kot
230009, Grodno, Gorkogo str., 80
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