Platelet microvesicles and their role in providing hemostatic capacity (literature review)
https://doi.org/10.15372/SSMJ20200201
Abstract
In recent years the role of microvesicles in endocrine system transmission, in providing cellular connectivity, in transportation of proteins and nucleic acids from one cell to another, in angiogenesis regulation, in inflammatory reactions and in dissemination of tumors is actively studied. This article reviews the mechanisms of microvesicle formation, the structure of microvesicles and their potential value as biomarkers. Among all essential reactions involving microvesicles one thing especially stands out: their direct participation in providing hemostatic reactions for bleeding control in case of a solution of continuity in blood vessels due to different reasons. Platelet microvesicles play an important role in this process, and it has been proved by several experimental and clinical studies. In this review we evaluate prospects for clinical use of one of modern blood components – cryoprecipitate – as the source of platelet microvesicles.
About the Authors
A. P. Momot
Altai Branch of National Research Center for Hematology of Minzdrav of Russia
Russian Federation
Russian Federation
Andrey P. Momot, doctor of medical sciences, professor
656045, Barnaul, Lyapidevskogo str., 1, bldg. 2
N. O. Tsarigorodtseva
Altai State Medical University of Minzdrav of Russia
Russian Federation
Russian Federation
Natalia O. Tsarigorodtseva
656038, Barnaul, Lenina av., 40
D. V. Fedorov
Altai State Medical University of Minzdrav of Russia
Russian Federation
Russian Federation
Dmitry V. Fedorov, doctor of medical sciences, professor
656038, Barnaul, Lenina av., 40
K. M. Bishevski
Altai State Medical University of Minzdrav of Russia
Russian Federation
Russian Federation
Konstantin M. Bishevski, candidate of medical sciences
656038, Barnaul, Lenina av., 40
N. V. Vostrikova
Altai State Medical University of Minzdrav of Russia
Russian Federation
Russian Federation
Natalia V. Vostrikova, candidate of medical sciences
656038, Barnaul, Lenina av., 40
E. E. Klimova
Altai State Medical University of Minzdrav of Russia
Russian Federation
Russian Federation
Elena E. Klimova, candidate of medical sciences
656038, Barnaul, Lenina av., 40
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Review
For citations:
Momot A.P., Tsarigorodtseva N.O., Fedorov D.V., Bishevski K.M., Vostrikova N.V., Klimova E.E. Platelet microvesicles and their role in providing hemostatic capacity (literature review). Сибирский научный медицинский журнал. 2020;40(2):4-14. (In Russ.) https://doi.org/10.15372/SSMJ20200201
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