CLINICAL AND HISTOLOGIC FEATURES OF UTERINE MYOMA IN REPRODUCTIVE-AGE WOMEN UNDER THE TREATMENT BY SELECTIVE PROGESTERONE RECEPTOR MODULATORS
https://doi.org/10.15372/SSMJ20200105
Abstract
Aim of the study was to investigate the clinical features of reproductive age women with uterine body myoma and the production of vascular endothelial growth factor (VEGF) in the dominant myoma node and perifocal myometrium under the preoperative use of ulipristal acetate (UA).
Material and methods. 140 samples of 35 women surgical material were studied, VEGF content in the incubation medium of samples of myoma and myometrium was measured using enzymelinked immunosorbent assay.
Results and discussion. The treatment by UA before myoma surgery according to the standard regimen per 5 mg daily for 13 weeks deals with significantly reduced production of VEGF in the dominant myoma node compared to perifocal myometrium (p < 0.001), which is similar to patients of the control group. However, when comparing tumor nodes, a significantly lower content of VEGF was revealed in the UA-group (p = 0.026); unlike the perifocal myometrium samples.
Conclusion. The use of a selective modulator of progesterone receptors downregulates the production of VEGF by the cells of the myoma nodes and doesn’t impact on the perifocal myometrium.
About the Authors
I. O. Marinkin
Novosibirsk State Medical University of Minzdrav of Russia
Russian Federation
doctor of medical sciences, professor
630091, Novosibirsk, Krasny av., 52
Russian Federation
doctor of medical sciences, professor
630091, Novosibirsk, Krasny av., 52
L. A. Piven’
Novosibirsk State Medical University of Minzdrav of Russia,
State Novosibirsk Regional Clinical Hospital
Russian Federation
candidate of medical sciences
630091, Novosibirsk, Krasny av., 52 630087, Novosibirsk, Nemirovich-Danchenko str., 130
Russian Federation
candidate of medical sciences
630091, Novosibirsk, Krasny av., 52 630087, Novosibirsk, Nemirovich-Danchenko str., 130
A. V. Volchek
Novosibirsk State Medical University of Minzdrav of Russia,
State Novosibirsk Regional Clinical Hospital
Russian Federation
630091, Novosibirsk, Krasny av., 52 630087, Novosibirsk, Nemirovich-Danchenko str., 130
Russian Federation
630091, Novosibirsk, Krasny av., 52 630087, Novosibirsk, Nemirovich-Danchenko str., 130
D. A. Solyanikov
State Novosibirsk Regional Clinical Hospital
Russian Federation
630087, Novosibirsk, Nemirovich-Danchenko str., 130
Russian Federation
630087, Novosibirsk, Nemirovich-Danchenko str., 130
Yu. V. Zenina
Novosibirsk State Medical University of Minzdrav of Russia
Russian Federation
630091, Novosibirsk, Krasny av., 52
Russian Federation
630091, Novosibirsk, Krasny av., 52
E. S. Mihaylova
Novosibirsk State Medical University of Minzdrav of Russia
Russian Federation
630091, Novosibirsk, Krasny av., 52
Russian Federation
630091, Novosibirsk, Krasny av., 52
V. V. Omigov
Novosibirsk State Medical University of Minzdrav of Russia
Russian Federation
630091, Novosibirsk, Krasny av., 52
Russian Federation
630091, Novosibirsk, Krasny av., 52
S. V. Aidagulova
Novosibirsk State Medical University of Minzdrav of Russia
Russian Federation
doctor of biological sciences, professor
630091, Novosibirsk, Krasny av., 52
Russian Federation
doctor of biological sciences, professor
630091, Novosibirsk, Krasny av., 52
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Review
For citations:
Marinkin I.O., Piven’ L.A., Volchek A.V., Solyanikov D.A., Zenina Yu.V., Mihaylova E.S., Omigov V.V., Aidagulova S.V. CLINICAL AND HISTOLOGIC FEATURES OF UTERINE MYOMA IN REPRODUCTIVE-AGE WOMEN UNDER THE TREATMENT BY SELECTIVE PROGESTERONE RECEPTOR MODULATORS. Сибирский научный медицинский журнал. 2020;40(1):39-44. (In Russ.) https://doi.org/10.15372/SSMJ20200105
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