Электрокардиографические изменения у крыс с метаболическим синдромом и сахарным диабетом 2 типа

   Нарушения функций сердечно-сосудистой системы при метаболическом синдроме (МС) и сахарном диабете типа 2 (СД2) в экспериментальных работах изучены недостаточно, а данные об изменениях параметров ЭКГ, в том числе на моделях МС и СД2 у грызунов, противоречивы и неоднозначны.

   Цель исследования – изучить показатели ЭКГ на моделях МС и СД2 и выявить возможные корреляции между нарушением толерантности к глюкозе и выраженностью изменений параметров ЭКГ.

   Материал и методы. В экспериментах использовали самцов крыс Wistar. МС индуцировали высокожировой диетой (ВЖД) продолжительностью 17 недель, СД2 вызывали комбинацией ВЖД и инъекции стрептозотоцина (ВЖД+СТЗ): 11 недель ВЖД с последующим введением стрептозотоцина и продолжением ВЖД еще в течение 6 недель. Контрольные животные содержались на стандартной диете.

   Результаты. Глюкозотолерантный тест подтвердил развитие нарушенной толерантности к глюкозе до преддиабетического уровня у группы ВЖД и до диабетического уровня у группы ВЖД+СТЗ. Изменения в ЭКГ обнаружены только в группе ВЖД+СТЗ: показано статистически значимое (по сравнению с контрольной группой и группой ВЖД) увеличение амплитуды и площади Т зубца на ЭКГ.

   Заключение. Выраженные нарушения ЭКГ развиваются только при моделировании СД2, но не МС.

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