Anxiety disorders in patients with infertility
https://doi.org/10.18699/SSMJ20250103
Abstract
The article is devoted to anxiety disorders in patients with infertility. Along with the physical aspects of this condition, many patients are experiencing significant emotional and psychological suffering. Women often experience feelings of loss, guilt, and loneliness. Unsuccessful trying to get pregnant can be a source of constant stress, affecting quality of life and relationships with partners and loved ones. The literature review presents modern data on the classification of infertility, symptoms of anxiety disorder, its etiology, the role of physiological, psychological and social factors, and the diagnosis of anxiety disorder using clinical and psychometric methods. The methods of treatment used are described, including psychopharmacological methods and psychotherapy. Anxiety disorders are a frequent companion of infertility, but they can and should be fought. A comprehensive approach including psychotherapy, medical treatment and support from loved ones helps many women to cope with anxiety and restore psycho-emotional balance.
About the Authors
A. N. Sulima
Crimean Federal University n.a. V.I. Vernadsky
Russian Federation
Russian Federation
Anna N. Sulima, doctor of medical sciences, professor
295051; Lenina blvd., 5/7; Simferopol
V. V. Stroevsky
Crimean Federal University n.a. V.I. Vernadsky
Russian Federation
Russian Federation
Vladimir V. Stroevsky, candidate of medical sciences
295051; Lenina blvd., 5/7; Simferopol
A. S. Bakharovskaya
Crimean Federal University n.a. V.I. Vernadsky
Russian Federation
Russian Federation
Anastasiya S. Bakharovskaya
295051; Lenina blvd., 5/7; Simferopol
References
1. Clinical recommendations. Female infertility. Available at: https://cr.minzdrav.gov.ru/schema/641_1 [In Russian].
2. Vasilieva A.V. Female mental health issues – interdisciplinary perspective. Russkiy meditsinskiy zhurnal. Meditsinskoye obozreniye = Russian Medical Journal. Medical Review. 2018;(10):51–56. [In Russian].
3. Chen T.H., Chang S.P., Tsai C.F., Juang K.D. Prevalence of depressive and anxiety disorders in an assisted reproductive technique clinic. Hum. Reprod. 2004;19(10):2313–2318. doi: 10.1093/humrep/deh414
4. Souter V.L., Hopton J.L., Penney G.C., Templeton A.A. Survey of psychological health in women with infertility. J. Psychosom. Obstet. Gynaecol. 2002;23(1):41–49. doi: 10.3109/01674820209093414
5. Maroufizadeh S., Karimi E., Vesali S., Samani R.O. Anxiety and depression after failure of assisted reproductive treatment among patients experiencing infertility. Int. J. Gynaecol. Obstet. 2015;130(3):253–256. doi: 10.1016/j.ijgo.2015.03.044
6. Gardanova Zh.R., Komissarova Yu.V. Boundary mental disorders and immunological changes in women with infertility in program of IVF. Vestnik novykh meditsinskikh tekhnologiy = Journal of New Medical Technologies. 2007;14(3):123. [In Russian].
7. Domar A.D., Broome A., Zuttermeister P.C., Seibel M., Friedman R. The prevalence and predictability of depression in infertile women. Fertil. Steril. 1992;58(6):1158–1163.
8. Palomba S., Daolio J., Romeo S., Battaglia F.A., Marci R., La Sala G.B. Lifestyle and fertility: the influence of stress and quality of life on female fertility. Reprod. Biol. Endocrinol. 2018;16(1):113. doi: 10.1186/s12958-018-0434-y
9. Degtyarev E.N., Shifman E.M., Tikhova G.P. Salivary alpha-amylase levels as an indicator of stress in pregnant women. Regionarnaya anesteziya i lechenie ostroy boli = Regional Anesthesia and Acute Pain Management. 2017;11(1):22–28. [In Russian]. doi: 10.18821/1993-6508-2017-11-1-22-28
10. Louis G.M.B., Lum K.J., Sundaram R., Chen Z., Kim S., Lynch C.D., Schisterman E.F., Pyper C. Stress reduces conception probabilities across the fertile window: evidence in support of relaxation. Fertil. Steril. 2011;95(7):2184–2189. doi: 10.1016/j.fertnstert.2010.06.078
11. McEwen B.S. Stressed or stressed out: what is the difference? J. Psychiatry Neurosci. 2005;30(5):315–318.
12. Dobson H., Ghuman S., Prabhakar S., Smith R. A conceptual model of the influence of stress on female reproduction. Reproduction. 2003;125(2):151–163. doi: 10.1530/rep.0.1250151
13. Gallinelli A., Roncaglia R., Matteo M.L., Ciaccio I., Volpe A., Facchinetti F. Immunological changes and stress are associated with different implantation rates in patients undergoing in vitro fertilization-embryo transfer. Fertil. Steril. 2001;76(1):85–91. doi: 10.1016/s0015-0282(01)01826-x
14. van den Broeck U., Emery M., Wischmann T., Thorn P. Counselling in infertility: individual, couple and group interventions. Patient Educ. Couns. 2010;81(3):422–428. doi: 10.1016/j.pec.2010.10.009
15. Cox L.W. Infertility: a comprehensive programme. British. J. Obstet. Gynaecol. 1975;82(1):2–6. doi: 10.1111/j.1471-0528.1975.tb00554.x
16. Golombok S. Psychological functioning in infertility patients. Hum. Reprod. 1992;7(2):208–212. doi: 10.1093/oxfordjournals.humrep.a137618
17. Yusuf L. Depression, anxiety and stress among female patients of infertility; A case control study. Pak. J. Med. Sci. 2016;32(6):1340–1343. doi: 10.12669/pjms.326.10828
18. Dyer S.J. The value of children in African countries – insights from studies on infertility. J. Psychosom. Obstet. Gynaecol. 2007;28(2):69–77. doi: 10.1080/01674820701409959
19. Matsubayashi H., Hosaka T., Izumi S., Suzuki T., Kondo A., Makino T. Increased depression and anxiety in infertile Japanese women resulting from lack of husband’s support and feelings of stress. Gen. Hosp. Psychiatry. 2004;26(5):398–404. doi: 10.1016/j.genhosppsych.2004.05.002
20. Luk B.H., Loke A.Y. The impact of infertility on the psychological well-being, marital relationships, sexual relationships, and quality of life of couples : a systematic review. J. Sex Marital Ther. 2015;41(6):610–625. doi: 10.1080/0092623X.2014.958789
21. Truong L.Q., Luong T.B., Tran T.H., Dang N.H., Nguyen L.H., Nguyen T.T., Nguyen P.T.H. Infertility-related stress, social support, and coping of women experiencing infertility in Vietnam. Health Psychol. Rep. 2022;10(2):129–138. doi: 10.5114/hpr.2022.113437
22. Wang L., Tang Y., Wang Y. Predictors and incidence of depression and anxiety in women undergoing infertility treatment: A cross-sectional study. PLoS One. 2023;18(4):e0284414. doi: 10.1371/journal.pone.0284414
23. Shani C., Yelena S., Reut B.K., Adrian S., Sami H. Suicidal risk among infertile women undergoing in-vitro fertilization: Incidence and risk factors. Psychiatry Res. 2016;240:53–59. doi: 10.1016/j.psychres.2016.04.003
24. Rooney K.L., Domar A.D. The relationship between stress and infertility. Dialogues Clin. Neurosci. 2018;20(1):41–47. doi: 10.31887/DCNS.2018.20.1/klrooney
25. Sapra A., Bhandari P., Sharma S., Chanpura T., Lopp L. Using generalized anxiety disorder-2 (GAD-2) and GAD-7 in a primary care setting. Cureus. 2020;12(5):e8224. doi: 10.7759/cureus.8224
26. Bjelland I., Dahl A.A., Haug T.T., Neckelmann D. The validity of the Hospital Anxiety and Depression Scale. An updated literature review. J. Psychosom. Res. 2002;52(2):69–77. doi: 10.1016/s0022-3999(01)00296-3
27. Gomez R., Stavropoulos V., Zarate D., Palikara O. Symptom Checklist-90-Revised: A structural examination in relation to family functioning. PLoS One. 2021;16(3):e0247902. doi: 10.1371/journal.pone.0247902
28. Muntingh A.D., van der Feltz-Cornelis C.M., van Marwijk H.W., Spinhoven P., Penninx B.W., van Balkom A.J. Is the Beck Anxiety Inventory a good tool to assess the severity of anxiety? A primary care study in the Netherlands Study of Depression and Anxiety (NESDA). BMC Fam. Pract. 2011;12:66. doi: 10.1186/1471-2296-12-66
29. Yang Z. Hamilton Anxiety Rating Scale. In: Encyclopedia of Gerontology and Population Aging. 2022. P. 2243–2246.
30. Julian L.J. Measures of anxiety: State-Trait Anxiety Inventory (STAI), Beck Anxiety Inventory (BAI), and Hospital Anxiety and Depression Scale-Anxiety (HADS-A). Arthritis Care Res. (Hoboken). 2011;63 Suppl 11(0 11):467–472. doi: 10.1002/acr.20561
31. Petelin D.S., Sorokina O.Yu., Troshina D.V., Siginevich Yu.A., Efimochkina S.M., Volel B.A. Anxiety disorders in general medical practice – clinical picture, diagnosis, optimized approaches to therapy. Meditsinskiy sovet = Medical Council. 2023;17(3):110–118. [In Russian]. doi: 10.21518/ms2023-053
32. Domar A.D., Clapp D., Slawsby E., Kessel B., Orav J., Freizinger M. The impact of group psychological interventions on distress in infertile women. Health Psychol. 2000;19(6):568–575. doi: 10.1037//0278-6133.19.6.568
33. Noorbala A.A., Ramazanzadeh F., Malekafzali H., Abedinia N., Forooshani A.R., Shariat M., Jafarabadi M. Effects of a psychological intervention on depression in infertile couples. Int. J. Gynaecol. Obstet. 2008;101(3):248–252. doi: 10.1016/j.ijgo.2007.12.010
34. Frederiksen Y., Farver-Vestergaard I., Skovgård N.G., Ingerslev H.J., Zachariae R. Efficacy of psychosocial interventions for psychological and pregnancy outcomes in infertile women and men : a systematic review and meta-analysis. BMJ Open. 2015;5(1):e006592. doi: 10.1136/bmjopen-2014-006592
35. Strawn J.R., Geracioti L., Rajdev N., Clemenza K., Levine A. Pharmacotherapy for generalized anxiety disorder in adult and pediatric patients : an evidence-based treatment review. Expert Opin. Pharmacother. 2018;19(10):1057–1070. doi: 10.1080/14656566.2018.1491966
36. Baldwin D.S., Anderson I.M., Nutt D.J., Allgulander C., Bandelow B., den Boer J.A., Christmas D.M., Davies S., Fineberg N., Lidbetter N. … Wittchen H.U. Evidence-based pharmacological treatment of anxiety disorders, post-traumatic stress disorder and obsessive-compulsive disorder: a revision of the 2005 guidelines from the British Association for Psychopharmacology. J. Psychopharmacol. 2014;28(5):403–439. doi: 10.1177/0269881114525674
37. Craske M.G., Stein M.B., Eley T.C., Milad M.R., Holmes A., Rapee R.M., Wittchen H.U. Anxiety disorders. Nat. Rev. Dis. Primers. 2017;3:17024. doi: 10.1038/nrdp.2017.24
38. Cuijpers P., Sijbrandij M., Koole S.L., Andersson G., Beekman A.T., Reynolds C.F. 3<sup>rd</sup>. Adding psychotherapy to antidepressant medication in depression and anxiety disorders: a meta-analysis. World Psychiatry. 2014;13(1):56–67. doi: 10.1002/wps.20089
39. Wang G., Liu X., Lei J. Effects of mindfulness-based intervention for women with infertility : a systematic review and meta-analysis. Arch. Womens Ment. Health. 2023;26(2):245–258. doi: 10.1007/+s00737-023-01307-2
Review
For citations:
Sulima A.N., Stroevsky V.V., Bakharovskaya A.S. Anxiety disorders in patients with infertility. Сибирский научный медицинский журнал. 2025;45(1):34-41. (In Russ.) https://doi.org/10.18699/SSMJ20250103
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