Oxidative stress and exogenous constitutional obesity
O. A. Silizertseva,
M. A. Darenskaya,
L. V. Rychkova,
I. N. Gutnik,
T. A. Astakhova,
L. I. Kolesnikova https://doi.org/10.18699/SSMJ20240607
Abstract
The literature review is devoted to the problem of exogenous-constitutional obesity and the role of oxidative stress (OS) in this form of obesity. The issues of modern diagnostics and pathogenesis of exogenous-constitutional obesity are considered. The results of various studies devoted to the study of OS in obesity in both laboratory animals and humans are presented. Excess body weight is often accompanied by increased OS and subclinical systemic inflammation. The need to correct the antioxidant status of the body is a topical issue, an important part of which is an individual approach to the selection of agents and dosages in order to reduce the negative impact of free radicals at the cellular level. A significant problem is the lack of a single standard for determining OS parameters, which requires standardized laboratory equipment, in this regard, the choice of a specific method is a responsible step for a research specialist. In this area, there are still many questions that require more detailed study.
About the Authors
O. A. Silizertseva
Irkutsk State University
Russian Federation
Russian Federation
Olesya A. Silizertseva.
664003, Irkutsk, Karla Marksa st., 1
M. A. Darenskaya
Scientific Centre for Family Health and Human Reproduction Problems
Russian Federation
Russian Federation
Marina A. Darenskaya - doctor of biological sciences, professor.
664003, Irkutsk, Timiryazeva st., 16
L. V. Rychkova
Scientific Centre for Family Health and Human Reproduction Problems
Russian Federation
Russian Federation
Lyubov V. Rychkova - doctor of medical sciences, professor, corresponding member of the RAS.
664003, Irkutsk, Timiryazeva st., 16
I. N. Gutnik
Irkutsk State University
Russian Federation
Russian Federation
Igor N. Gutnik - doctor of biological sciences, professor.
664003, Irkutsk, Karla Marksa st., 1
T. A. Astakhova
Scientific Centre for Family Health and Human Reproduction Problems
Russian Federation
Russian Federation
Tatyana A. Astakhova - candidate of medical sciences.
664003, Irkutsk, Timiryazeva st., 16
L. I. Kolesnikova
Irkutsk State University; Scientific Centre for Family Health and Human Reproduction Problems
Russian Federation
Russian Federation
Lyubov I. Kolesnikova - doctor of medical sciences, academician of the RAS.
664003, Irkutsk, Karla Marksa st., 1; 664003, Irkutsk, Timiryazeva st., 16
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