The role of extracellular ATP in regulating the functional activity of cells
https://doi.org/10.18699/SSMJ20240506
Abstract
A search and analysis of scientific articles presented in the databases PubMed, ScienceDirect, Elsevier, eLibrary for 2000–2024 was carried out. The selection criterion was the presence in the articles of information on the concentration of extracellular ATP in normal and pathological tissues, the mechanisms of purinergic regulation of cell functioning, and the expression of CD73 and CD39 ectonucleotidases on cells, which regulate proinflammatory extracellular ATP catabolism to immunosuppressive adenosine. Modern data are presented on the role of extracellular ATP in the regulation of cell functioning under normal and pathological conditions, during inflammation and the formation of cellular and humoral immune responses, as well as on the study of the mechanisms of purinergic signaling from extracellular ATP in the development of targeted drugs for various diseases, including neoplasms, neurodegenerative and autoimmune pathologies.
Supporting agencies: The study was performed within the Program of Fundamental Scientific Research on the topic of the environmental immunology laboratory, Institute of Physiology of Natural Adaptations of N. Laverov Federal Center for Integrated Arctic Research, Ural Branch of the Russian Academy of Sciences (project № 122011300377-5).
About the Author
V. P. Patrakeeva
Institute of Physiology of Natural Adaptations of N. Laverov Federal Center for Integrated Arctic Research of UrB RAS
Russian Federation
Russian Federation
Veronika P. Patrakeeva, candidate of biological sciences
163065 Arkhangelsk, Nikolsky ave., 20
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Review
For citations:
Patrakeeva V.P. The role of extracellular ATP in regulating the functional activity of cells. Сибирский научный медицинский журнал. 2024;44(5):53-60. (In Russ.) https://doi.org/10.18699/SSMJ20240506
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