The role of epithelial alarmins and Th2 cytokines in the inflammatory response in allergic rhinitis
V. V. Makarevich,
A. D. Taganovich,
T. V. Mironova,
I. P. Shilovskiy,
M. R. Khaitov,
A. G. Kadushkin https://doi.org/10.18699/SSMJ20240504
Abstract
Allergic rhinitis (AR) occupies a leading position among the causes of morbidity throughout the world, to date, it has been diagnosed in 400 million people. In the formation and progression of AR, a significant role is assigned to cytokines associated with the second type of immune response, in particular, IL-4, IL-5, IL-9, IL-13, IL-25, IL-33, thymic stromal lymphopoietin (TSLP). This literature review provides information on the influence of the listed mediators on the structural cells of the nasal cavity and blood immune cells (T- and B-lymphocytes, eosinophils, macrophages, dendritic cells), and discusses their association with the manifestation of AR symptoms and the severity of the disease. The results of studies aimed at establishing the level of IL-4, IL-5, IL-9, IL-13, IL-25, IL-33 and TSLP in biological fluids (blood serum, nasal lavage) and their expression in nasal epithelial cells in patients with AR compared to healthy people are assessed.
Supporting agencies: The study was carried out within the framework of a joint assignment of the Belarusian Republican Foundation for Fundamental Research and the Russian Science Foundation (contract No. M23RNF-021, state registration No. 20230281).
About the Authors
V. V. Makarevich
Belarusian State Medical University of Minzdrav of the Republic of Belarus
Belarus
Belarus
Vasilina V. Makarevich
220083, Minsk, Dzerzhinskogo ave., 83
A. D. Taganovich
Belarusian State Medical University of Minzdrav of the Republic of Belarus
Belarus
Belarus
Anatoly D. Taganovich, doctor of medical sciences, professor
220083, Minsk, Dzerzhinskogo ave., 83
T. V. Mironova
Belarusian State Medical University of Minzdrav of the Republic of Belarus
Belarus
Belarus
Tatiana V. Mironova
220083, Minsk, Dzerzhinskogo ave., 83
I. P. Shilovskiy
National Research Center – Institute of Immunology of the Federal Medical-Biological Agency
Russian Federation
Russian Federation
Igor P. Shilovskiy, doctor of biological sciences
115522, Moscow, Kashirskoe highw., 24
M. R. Khaitov
National Research Center – Institute of Immunology of the Federal Medical-Biological Agency ; N.I. Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Musa R. Khaitov, doctor of medical sciences, professor, corresponding member of RAS
115522, Moscow, Kashirskoe highw., 24
117997, Moscow, Ostrovityanova st., 1
A. G. Kadushkin
Belarusian State Medical University of Minzdrav of the Republic of Belarus
Belarus
Belarus
Aliaksei G. Kadushkin, doctor of medical sciences
220083, Minsk, Dzerzhinskogo ave., 83
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Makarevich V.V., Taganovich A.D., Mironova T.V., Shilovskiy I.P., Khaitov M.R., Kadushkin A.G. The role of epithelial alarmins and Th2 cytokines in the inflammatory response in allergic rhinitis. Сибирский научный медицинский журнал. 2024;44(5):35-45. (In Russ.) https://doi.org/10.18699/SSMJ20240504
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