The role of bioelements ‒ components of free radical oxidation ‒ in the genesis of childhood obesity
A. S. Lesnaya,
M. A. Darenskaya,
L. V. Rychkova,
N. V. Semenova,
Zh. V. Prokhorova,
V. А. Shevchuk,
L. I. Kolesnikova https://doi.org/10.18699/SSMJ20240503
Abstract
Currently, there is no common understanding of the bioelement status of obese children and adolescents. In this regard, we have summarized the available data on open access and presented information on the role and content of bioelements involved in the regulation of free radical homeostasis in the genesis of childhood obesity. The literature review revealed modern ideas about obesity as a metabolic pathology. The multifactorial nature of the development of oxidative stress in obesity, including in children and adolescents, is considered, the role of bioelements in the regulation of free radical homeostasis is revealed and it is shown that they can act as cofactors of antioxidant enzymes and/or be initiators of oxidative reactions. The most significant bioelements involved in the regulation of free radical processes are copper, zinc, manganese, selenium and iron. The analysis of the literature shows that children and adolescents with obesity experience changes in the metabolism of the main bioelements involved in the regulation of redox homeostasis. The content of copper, zinc, selenium, manganese and iron may vary depending on the gender and age of the subjects, as well as the type of biomaterial being studied.
About the Authors
A. S. Lesnaya
Scientific Centre for Family Health and Human Reproduction Problems
Russian Federation
Russian Federation
Anastasiya S. Lesnaya, candidate of biological sciences
664003, Irkutsk, Timiryazeva st., 16
M. A. Darenskaya
Scientific Centre for Family Health and Human Reproduction Problems
Russian Federation
Russian Federation
Marina A. Darenskaya, doctor of biological sciences, professor of the RAS
664003, Irkutsk, Timiryazeva st., 16
L. V. Rychkova
Scientific Centre for Family Health and Human Reproduction Problems
Russian Federation
Russian Federation
Lyubov V. Rychkova, doctor of medical sciences, professor, corresponding member of RAS
664003, Irkutsk, Timiryazeva st., 16
N. V. Semenova
Scientific Centre for Family Health and Human Reproduction Problems
Russian Federation
Russian Federation
Natalya V. Semenova, doctor of biological sciences
664003, Irkutsk, Timiryazeva st., 16
Zh. V. Prokhorova
Scientific Centre for Family Health and Human Reproduction Problems
Russian Federation
Russian Federation
Zhanna V. Prokhorova, candidate of biological sciences
664003, Irkutsk, Timiryazeva st., 16
V. А. Shevchuk
Scientific Centre for Family Health and Human Reproduction Problems
Russian Federation
Russian Federation
Valeria А. Shevchuk
664003, Irkutsk, Timiryazeva st., 16
L. I. Kolesnikova
Scientific Centre for Family Health and Human Reproduction Problems
Russian Federation
Russian Federation
Lyubov I. Kolesnikova, doctor of medical sciences, рrofessor, academician of the RAS
664003, Irkutsk, Timiryazeva st., 16
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Lesnaya A.S., Darenskaya M.A., Rychkova L.V., Semenova N.V., Prokhorova Zh.V., Shevchuk V.А., Kolesnikova L.I. The role of bioelements ‒ components of free radical oxidation ‒ in the genesis of childhood obesity. Сибирский научный медицинский журнал. 2024;44(5):24-34. (In Russ.) https://doi.org/10.18699/SSMJ20240503
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