To the question of thrombotic and hemorrhagic complications in patients with COVID-19
N. I. Glushkov,
P. D. Puzdriak,
A. N. Zvyagintseva,
E. I. Panasyuk,
V. Yu. Gavrilov,
M. A. Ivanov,
K. V. Zhdanovich https://doi.org/10.18699/SSMJ20240416
Abstract
COVID-19 is characterized by various adverse consequences and complications, the prevention of which affects the outcome of the disease. Aim of the study was to investigate the thrombohemorrhagic events of COVID-19 infection. Material and methods. This study involved 403 patients with novel coronavirus infection; the patients were divided into 2 groups: 75 with COVID-19 complications and 328 patients without complications. Metabolic disorders, features of lung damage, comorbidity, signs of inflammation and coagulation, treatment outcomes, peculiarities of thrombotic events and hemorrhages development were studied. Results and its discussion. Thrombohemorrhagic complications of COVID-19 occurred mostly in patients with angina pectoris, coronary artery sclerosis and chronic heart failure of functional class II–III, as well as decompensated diabetes mellitus and obesity. These coronavirus infection effects are often accompanied by an increase in content of inflammatory markers such as CRP and ferritin, as well as of hypercoagulability (D-dimers). Conclusions. Manifestations of inflammatory coagulopathy in patients infected by COVID-19 increases risk of thrombohemorrhagic complications.
About the Authors
N. I. Glushkov
Northwestern State Medical University named after. I. I. Mechnikov of Minzdrav of Russia
Russian Federation
Russian Federation
Nikolay I. Glushkov, doctor of medical sciences, professor
195067, Saint-Petersburg, Piskarevsky ave., 47
P. D. Puzdriak
Northwestern State Medical University named after. I. I. Mechnikov of Minzdrav of Russia
Russian Federation
Russian Federation
Petr D. Puzdriak
195067, Saint-Petersburg, Piskarevsky ave., 47
A. N. Zvyagintseva
Northwestern State Medical University named after. I. I. Mechnikov of Minzdrav of Russia
Russian Federation
Russian Federation
Anastasia N. Zvyagintseva
195067, Saint-Petersburg, Piskarevsky ave., 47
E. I. Panasyuk
Northwestern State Medical University named after. I. I. Mechnikov of Minzdrav of Russia
Russian Federation
Russian Federation
Eleonora I. Panasyuk
195067, Saint-Petersburg, Piskarevsky ave., 47
V. Yu. Gavrilov
Northwestern State Medical University named after. I. I. Mechnikov of Minzdrav of Russia
Russian Federation
Russian Federation
Vladislav Yu. Gavrilov
195067, Saint-Petersburg, Piskarevsky ave., 47
M. A. Ivanov
Northwestern State Medical University named after. I. I. Mechnikov of Minzdrav of Russia
Russian Federation
Russian Federation
Mikhail A. Ivanov, doctor of medical sciences, professor
195067, Saint-Petersburg, Piskarevsky ave., 47
K. V. Zhdanovich
Northwestern State Medical University named after. I. I. Mechnikov of Minzdrav of Russia
Russian Federation
Russian Federation
Kristina V. Zhdanovich
195067, Saint-Petersburg, Piskarevsky ave., 47
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