Elecampane: a review of the pharmacological effects of active substances in diseases of the bronchopulmonary system
https://doi.org/10.18699/SSMJ20240405
Abstract
Chronic diseases of the bronchopulmonary system have reached epidemic levels worldwide, and the situation is deteriorating as the degree of urbanization increases. Elecampane is called Russian ginseng, because the active ingredients of its roots have a multifaceted effect on the body. In diseases of the bronchopulmonary system, they promote expectoration of sputum, stimulate blood circulation and saturate the blood with oxygen, have an immunomodulatory effect, which helps to fight viral and bacterial infections of the lungs. Especially relevant is the use of elecampane preparations for the treatment of pulmonary tuberculosis, mycoplasma respiratory infection and viral infections such as COVID-19, herpesviruses, which can provoke serious lung changes, including pneumatic fibrosis and pneumosclerosis, which are formed within three months or more, and the resulting fibrosis foci are not subject to involution. Meanwhile at the stage of development of the process, fibrous changes can be minimized by both drug and phytotherapy treatment. The antiviral effect of elecampane preparations may play a role in modifying or slowing the progression of pulmonary fibrosis, especially when used at an early stage. In bronchial asthma, elecampane preparations can weaken the immuneinflammatory response.
About the Author
O. Sh. Atabaeva
Altai State Medical University of Minzdrav of Russia
Russian Federation
Russian Federation
Olga Sh. Atabaeva, candidate of biological sciences
656038, Barnaul, Lenina ave., 40
References
1. Zelenskaya K.L., Pashinskij V.G., Povet’eva T.N., Nesterova Yu.V. Elecampane – adaptogen and antihypoxant. Tomsk: TGPU, 2004. 204 р. [In Russian].
2. Rasulova M.O. Stady of the chemical composition of the Inula helenium plant. European Scholar Journal. 2021;2(3):58–61.
3. Matasova S.A., Mitina N.A., Ryzhova G.L., Zhuganov D.O., Dychko K.A. Obtaining a dry extract from the roots of high-grade elecampane and studying its chemical composition. Khimiya rastitel’nogo syr’ia = Chemistry of Plant Raw Material. 1999;(2):119–123. [In Russian].
4. Artem’eva V.A., Yamashev T.A., Pankratova T.A., Poltanova K.S., Reshetnik O.A. Research of antioxidant and antiradical properties of extracts of roots and rhizomes of elecampane (Inula L.) Vestnik Kazanskogo tekhnologicheskogo universiteta = Bulletin of the Technological University. 2017;20(20):109– 111. [In Russian].
5. Khlebtsova E.B., Bataev H.M. Clinical pharmacology: a textbook in schemes, tests and tasks. Groznyj: Publishing House of the Chechen State University, 2020. 112 p. [In Russian].
6. Bubenchikova V.N., Azarova A.V. Composition and expectorant activity of water-soluble polysaccharide complexes of ivolistny elecampane. Nauchnye vedomosti Belgorodskogo gosudarstvennogo universiteta. Seriya Estestvennye nauki = Scientific Statements of Belgorod State University. Series: Natural Sciences. 2011;(15-2):189–191. [In Russian].
7. Uchasova E.G. Regulation of macrophage activity by polysaccharides of common mother-and-stepmother, calamus marsh, calendula officinalis, high elecampane. Abstract of thesis …cand. med. sci. Tomsk, 2009. [In Russian].
8. Petrov R.V., Khaitov R.M., Nekrasov A.V., Attaulakhanov R.I., Puchkova N.G., Ivanova A.S., Pinegin B.V., Khamidullina K.F., Dambaeva S.V., Klimova S.V. Polyoxidonium – mechanisms of action and clinical relevance. Meditsinskaya immunologiya = Medical Immunology. 2000;2(3):271–278. [In Russian].
9. Danilets M.G. Pharmacological regulation of the functional state of macrophages in the immune response. Abstract of thesis …doct. med. sci. Tomsk, 2011. [In Russian].
10. Pearson G., Robinson F., Beers Gibson T., Xu B.E., Karandikar M., Berman K., Cobb M.H. Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr. Rev. 2001;22(2):153–183. doi: 10.1210/edrv.22.2.0428
11. Stojanovic-Radic Z., Comic L., Radulovic N., Blagojevic P., Denic M., Miltojevic A., Rajkovic J., Mihajilov-Krstev T. Antistaphylococcal activity of Inula helenium L. root essential oil: eudesmane sesquiterpene lactones induce cell membrane damage. Eur. J. Clin. Microbiol. Infect. Dis. 2012;31(6):1015–1025. doi: 10.1007/s10096-011-1400-1
12. Pukhov S.A., Neganova M.E., Anikina L.V., Shevtsova E.F., Afanaseva S.V., Klochkov S.G. Epoxyalantolactone and its derivaives inhibit the growth of mammary gland adenocarcinomas. Fundamental’nye issledovaniya = Fundamental Research. 2014;9(9):1988–1992. [In Russian].
13. Burova L.G., Shirokikh I.V., Patrushev S.S., Tolstikova T.G., Shultz E.E. Structure and antibacterial activity of isoalantolactone derivatives. Fundamental’naya i klinicheskaya meditsina = Fundamental and Clinical Medicine. 2017;2(1):28–34. [In Russian].
14. Pozhilova E.V., Novikov V.E., Levchenkova O.S. Reactive oxygen species in cell physiology and pathology. Vestnik Smolenskoy gosudarstvennoy meditsinskoy akademii = Vestnik of the Smolensk State Medical Academy. 2015;14(2):13–22. [In Russian].
15. Simbirtsev A.S., Totolyan A.A. Cytokines in laboratory diagnostics. Infektsionnye bolezni: novosti, mneniya, obuchenie=Infectious Diseases: News, Opinions, Training. 2015;(2):82–98. [In Russian].
16. Flannagan R.S., Kuiack R.C., McGavin M.J., Heinrichs D.E. Staphylococcus aureus uses the GraXRS regulatory system to sense and adapt to the acidified phagolysosome in macrophages. mBio. 2018;9(4):e01143-18. doi: 10.1128/mBio.01143-18
17. Mosser D.M., Edwards J.P. Exploring the full spectrum of macrophage activation. Nat. Rev. Immunol. 2008;8(12):958–969. doi: 10.1038/nri2448
18. Kreider T., Anthony R.M., Urban J.F.Jr., Gause W.C. Alternatively activated macrophages in helminth infections. Curr. Opin. Immunol. 2007;19(4):448–453. doi: 10.1016/j.coi.2007.07.002
19. Liu Y.C., Zou X.B., Chai Y.F., Yao Y.M. Macrophage polarization in inflammatory diseases. Int. J. Biol. Sci. 2014;10(5): 520–529. doi: 10.7150/ijbs.8879
20. Levinson U. Medical microbiology and immunology. Moscow: Laboratory of Knowledge, 2020. 1181 p. [In Russian].
21. Tarahovskij Yu.S., Kim Yu.A., Abdrasilov B.S., Muzafarov E.N. Flavonoids: biochemistry, biophysics, medicine. Pushchino: Sunchrobook, 2013. 310 р. [In Russian].
22. Lushova A.A., Zheremyan E.A., Astakhova E.A., Spiridonova A.B., Byazrova M.G., Filatov A.V. B-lymphocyte subsets: functions and molecular markers Immunologiya = Immunology. 2019; 40(6):63–76. [In Russian]. doi: 10.24411/0206-4952-2019-16009
23. Lesiovskaya E.E. Evidence-based phytotherapy: a guide for doctors and pharmacists. Saint-Petersburg: Photo Time, 2020. Vol. 3. 397 p. [In Russian].
24. Lazutkina E.L., Lazarenko L.L., Landyshev Yu.S., Cyrendorzhiev D.D., Landyshev S.Yu. The effectiveness of the interferon inducer in the period of exacerbation of bronchial asthma against the background of acute respiratory viral infection. Byulleten’ fiziologii i patologii dykhaniya = Bulletin of Physiology and Pathology of Respiration. 2012;(43):23–27. [In Russian].
25. Duckworth A., Longhurst H.J., Paxton J.K., Scotton C.J. The role of herpes viruses in pulmonary fibrosis. Front. Med. (Lausanne). 2021;8:704222. doi: 10.3389/fmed.2021.704222
26. Funes S.C., Rios M., Escobar-Vera J., Kalergis A.M. Implications of macrophage polarization in autoimmunity. Immunology. 2018;154(2):186–195. doi: 10.1111/imm.12910
27. Wermuth P.J., Jimenez S.A. The significance of macrophage polarization subtypes for animal models of tissue fibrosis and human fibrotic diseases. Clin. Transl. Med. 2015;4:2. doi: 10.1186/s40169-015-0047-4
28. Pechkovsky D.V., Prasse A., Kollert F., Engel K.M.Y., Dentler J., Luttmann W., Friedrich K., Müller-Quernheim J., Zissel G. Alternatively activated alveolar macrophages in pulmonary fibrosis-mediator production and intracellular signal transduction. Clin. Immunol. 2010;137(1):89–101. doi: 10.1016/j.clim.2010.06.017
29. Wang H., Wu J., Ma L., Bai Y., Liu J. The role of interleukin-1 family in fibrotic diseases. Cytokine. 2023;165:156161. doi: 10.1016/j.cyto.2023.156161
30. Klochkov S.G., Pukhov S.A., Neganova M.E., Dubrovskaya E.S., Anikina L.V., Afanasyeva S.V., Semakov A.V. Biological activity of alantolactones in experiments on cells. Biomedical Chemistry: Research and Methods. 2018;1(3):e00047. [In Russian]. doi: 10.18097/BMCRM00047
31. Qian B.-Zh., Pollard J.W. Macrophage diversity enhances tumor progression and metastasis. Cell. 2010;141(1):39–51. doi: 10.1016/j.cell.2010.03.014
32. Mantovani A., Marchesi F., Malesci A., Laghi L., Allavena P. Tumour-associated macrophages as treatment targets in oncology. Nat. Rev. Clin. Oncol. 2017;14(7):399–416. doi: 10.1038/nrclinonc.2016.217
33. Lewis C.E., Pollard J.W. Distinct role of macrophages in different tumor microenvironments. Cancer Res. 2006;66(2):605–612. doi: 10.1158/0008-5472.CAN-05-4005
34. Sica A., Larghi P., Mancino A., Rubino L., Porta C., Totaro M.G., Rimoldi M., Biswas S.K., Allavena P., Mantovani A. Macrophage polarization in tumour progression. Semin. Cancer Biol. 2008;18(5):349–355. doi: 10.1016/j.semcancer.2008.03.004
35. Bui T.V., Ayari H., Baron S., Bertocchio J.P., Bureau C., Davis P., Blanchard A., Houillier P., Prie D., Lillo-Le Louet A., Courbebaisse M. Safety of inulin and sinistrin: combining several sources for pharmacovigilance purposes. Front. Pharmacol. 2021;12:725417. doi: 10.3389/fphar.2021.725417
Review
For citations:
Atabaeva O.Sh. Elecampane: a review of the pharmacological effects of active substances in diseases of the bronchopulmonary system. Сибирский научный медицинский журнал. 2024;44(4):53-61. (In Russ.) https://doi.org/10.18699/SSMJ20240405
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