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RARE DISEASES OF THE BLOOD SYSTEM: A CLINICAL CASE OF VIRUS-ASSOCIATED BONE MARROW APLASIA IN A PATIENT WITH A HEREDITARY MEMBRANOPATHY (REVIEW)

https://doi.org/10.15372/SSMJ20190112

Abstract

The aim of study was to research and present literature data regarding the investigations of some combined types of anemia in pregnancy and to describe the clinical case of pregnancy associated with primary parvovirus B19 infection and newly diagnosed hereditary erythrocyte membrane disorder. The contemporary information about the etiology, the prevalence, structure and some features of pathogenesis of parvovirus infection based on literature data was given. The huge prevalence of this infection (according to data of different sources the serum level of parvovirus B19 specific antibodies may be detect in 90 % of population), its threat for fetus and risk of severe complications in patients with immunodeficiency, as well as possibility of development of total depression of hematopoiesis in patients with hereditary erythrocyte membrane disorders, such as Minkowsky-Chauffard disease, determine the relevance and significance of the discussed topic. Furthermore, this clinical case, which illustrates the features of primary parvovirus B19 infection in patient with hereditary hemolytic anemia and the difficulties of differential diagnosis, demonstrates the importance of parvovirus infection markers detection, which is not available in the most TORCH-panel.

About the Authors

A. V. Zabela
Novosibirsk State Medical University of Minzdrav of Russia
Russian Federation

Andrey Vladimirovich ZABELA – student of the 5th course of the pediatric faculty

630091, Novosibirsk, Krasny av., 52



V. S. Selivanov
Novosibirsk State Medical University of Minzdrav of Russia
Russian Federation

Vitaliy Sergeevich SELIVANOV – student of the 5th course of the pediatric faculty 

630091, Novosibirsk, Krasny av., 52



T. N. Babaeva
Novosibirsk State Medical University of Minzdrav of Russia
Russian Federation

Tatyana Nikolaevna BABAEVA – candidate of medical sciences, assistant professor of the department of therapy, hematology and transfusiology 

630091, Novosibirsk, Krasny av., 52



I. B. Kovynev
Novosibirsk State Medical University of Minzdrav of Russia
Russian Federation

Igor Borisovich KOVYNEV – doctor of medical sciences, associate professor of the department of therapy, hematology and transfusiology 

630091, Novosibirsk, Krasny av., 52



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Review

For citations:


Zabela A.V., Selivanov V.S., Babaeva T.N., Kovynev I.B. RARE DISEASES OF THE BLOOD SYSTEM: A CLINICAL CASE OF VIRUS-ASSOCIATED BONE MARROW APLASIA IN A PATIENT WITH A HEREDITARY MEMBRANOPATHY (REVIEW). Сибирский научный медицинский журнал. 2019;39(1):84-89. (In Russ.) https://doi.org/10.15372/SSMJ20190112

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