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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">sibmed</journal-id><journal-title-group><journal-title xml:lang="ru">Сибирский научный медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Сибирский научный медицинский журнал</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2410-2512</issn><issn pub-type="epub">2410-2520</issn><publisher><publisher-name>ИЦиГ СО РАН</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18699/SSMJ20220601</article-id><article-id custom-type="elpub" pub-id-type="custom">sibmed-929</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>Потенциальные новые точки приложения ингибиторов SGLT2 у пациентов с сердечной недостаточностью в сочетании с сахарным диабетом, неалкогольной жировой болезнью печени и анемией (обзор литературы)</article-title><trans-title-group xml:lang="en"><trans-title>Potential new application points of SGLT2 inhibitors in patients with heart failure in combination with diabetes mellitus, non-alcoholic fatty liver disease and anemia (literature review)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0207-7063</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Цыганкова</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Tsygankova</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Оксана Васильевна Цыганкова, д.м.н.</p><p>630089, г. Новосибирск, ул. Бориса Богаткова, 175/1630091, г. Новосибирск, Красный пр., 52</p></bio><bio xml:lang="en"><p>Oksana V. Tsygankova, doctor of medical sciences</p><p>630089, Novosibirsk, Boris Bogatkov str., 175/1</p><p>630091, Novosibirsk, Krasny ave., 52</p></bio><email xlink:type="simple">oksana_c.nsk@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6584-2060</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тимощенко</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Timoshchenko</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ольга Владимировна Тимощенко, к.м.н.</p><p>630089, г. Новосибирск, ул. Бориса Богаткова, 175/1</p></bio><bio xml:lang="en"><p>Olga V. Timoshchenko, candidate of medical sciences</p><p>630089, Novosibirsk, Boris Bogatkov str., 175/1</p></bio><email xlink:type="simple">lentis@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4312-7621</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тузовская</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Tuzovskaya</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ольга Викторовна Тузовская</p><p>630089, г. Новосибирск, ул. Бориса Богаткова, 175/1</p></bio><bio xml:lang="en"><p>Olga V. Tuzovskaya</p><p>630089, Novosibirsk, Boris Bogatkov str., 175/1</p></bio><email xlink:type="simple">o.nazarenko@alumni.nsu.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1913-5231</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Латынцева</surname><given-names>Л. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Latyntseva</surname><given-names>L. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Людмила Дмитриевна Латынцева, к.м.н.</p><p>630089, г. Новосибирск, ул. Бориса Богаткова, 175/1</p></bio><bio xml:lang="en"><p>Lyudmila D. Latyntseva, candidate of medical sciences</p><p>630089, Novosibirsk, Boris Bogatkov str., 175/1</p></bio><email xlink:type="simple">ludmilanov2010@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4601-6203</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Николаев</surname><given-names>К. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Nikolaev</surname><given-names>K. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Константин Юрьевич Николаев, д.м.н., проф.</p><p>630089, г. Новосибирск, ул. Бориса Богаткова, 175/1</p></bio><bio xml:lang="en"><p>Konstantin Yu. Nikolaev, doctor of medical sciences, professor</p><p>630089, Novosibirsk, Boris Bogatkov str., 175/1</p></bio><email xlink:type="simple">nikolaevky@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>НИИ терапии и профилактической медицины – филиал ФИЦ Институт цитологии и генетики СО РАН; Новосибирский государственный медицинский университет Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Research Institute of Internal and Preventive Medicine – Branch of the Federal Research Center Institute of Cytology and Genetics SB RAS; Novosibirsk State Medical University of Minzdrav of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>НИИ терапии и профилактической медицины – филиал ФИЦ Институт цитологии и генетики СО РАН</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Research Institute of Internal and Preventive Medicine – Branch of the Federal Research Center Institute of Cytology and Genetics SB RAS</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>25</day><month>12</month><year>2022</year></pub-date><volume>42</volume><issue>6</issue><fpage>4</fpage><lpage>14</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Цыганкова О.В., Тимощенко О.В., Тузовская О.В., Латынцева Л.Д., Николаев К.Ю., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Цыганкова О.В., Тимощенко О.В., Тузовская О.В., Латынцева Л.Д., Николаев К.Ю.</copyright-holder><copyright-holder xml:lang="en">Tsygankova O.V., Timoshchenko O.V., Tuzovskaya O.V., Latyntseva L.D., Nikolaev K.Y.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://sibmed.elpub.ru/jour/article/view/929">https://sibmed.elpub.ru/jour/article/view/929</self-uri><abstract><p>Хроническая сердечная недостаточность является глобальной кардиологической проблемой. Последнее десятилетие можно справедливо назвать прорывным в лечении данной нозологии благодаря появлению новой группы лекарственных средств – ингибиторов натрий-глюкозного котранспортера 2 типа (SGLT2) (глифлозинов), которые у пациентов как с имеющейся исходно сердечной недостаточностью с различной фракцией выброса, так и при наличии факторов риска ее развития оказывают стойкое положительное влияние на число госпитализаций по поводу сердечной недостаточности. Привлекательным для клинициста является и ряд плейотропных эффектов ингибиторов SGLT2, к которым относят умеренную потерю массы тела, уменьшение жировых отложений в висцеральных жировых депо, снижение уровня печеночных трансаминаз в крови, стимуляцию эритропоэза, что органично дополняет стратегию комплексной кардиоренометаболической протекции и подчеркивает уникальную роль этого класса препаратов в современной кардиологии. В недалеком будущем нам предстоит узнать результаты продолжающихся в настоящее время множественных исследований глифлозинов, что, высоко вероятно, откроет новые исторические горизонты в терапии пациентов с кардиоваскулярными заболеваниями, в том числе различных категорий пациентов с острой и хронической сердечной недостаточностью. </p></abstract><trans-abstract xml:lang="en"><p>Chronic heart failure is a global cardiac problem. The last decade can rightly be called a breakthrough in the treatment of this nosology, due to the emergence of a new group of drugs – SGLT2 inhibitors (gliflozins), which, both in patients with initial heart failure with different ejection fraction, and in the presence of risk factors for its development, have a persistent positive impact on the number of hospitalizations for heart failure. A number of pleiotropic effects of SGLT2 inhibitors are also attractive to the clinician, which include moderate weight loss, a decrease in body fat in visceral fat depots, a decrease in the level of hepatic transaminases in the blood, stimulation of erythropoiesis, which organically complements the strategy of complex cardiorenometabolic protection and emphasizes the unique role of this class drugs in modern cardiology. In the near future, we will have to learn the results of the ongoing multiple studies of gliflozin, which is highly likely to open new historical horizons in the treatment of patients with cardiovascular diseases, including various categories of patients with acute and chronic heart failure. </p></trans-abstract><kwd-group xml:lang="ru"><kwd>ингибиторы SGLT2</kwd><kwd>глифлозины</kwd><kwd>хроническая сердечная недостаточность</kwd><kwd>сахарный  диабет 2 типа</kwd><kwd>анемия</kwd><kwd>неалкогольная жировая болезнь печени</kwd></kwd-group><kwd-group xml:lang="en"><kwd>SGLT2 inhibitors</kwd><kwd>gliflozins</kwd><kwd>chronic heart failure</kwd><kwd>type 2 diabetes mellitus</kwd><kwd>anemia</kwd><kwd>non-alcoholic fatty liver disease</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Работа выполнена частично по Государственному заданию в рамках бюджетной темы  рег. № 122031700094-5</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Российское кардиологическое общество (РКО). Хроническая сердечная недостаточность. Клинические рекомендации 2020. Рос. кардиол. ж. 2020;25(11):4083. doi: 10.15829/1560-4071-2020- 4083 Russian Society of Cardiology (RSC). 2020. Clinical practice guidelines for chronic heart failure. Rossiyskiy kardiologicheskiy zhurnal = Russian Journal of Cardiology. 2020;25(11):4083. [In Russian]. doi: 10.15829/1560-4071-2020-4083</mixed-citation><mixed-citation xml:lang="en">Российское кардиологическое общество (РКО). Хроническая сердечная недостаточность. Клинические рекомендации 2020. Рос. кардиол. ж. 2020;25(11):4083. doi: 10.15829/1560-4071-2020- 4083 Russian Society of Cardiology (RSC). 2020. Clinical practice guidelines for chronic heart failure. Rossiyskiy kardiologicheskiy zhurnal = Russian Journal of Cardiology. 2020;25(11):4083. [In Russian]. doi: 10.15829/1560-4071-2020-4083</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Redfield M.M. Heart failure with preserved ejection fraction. N. Engl. J. Med. 2016;375(19):1868– 1877. doi: 10.1056/NEJMcp1511175</mixed-citation><mixed-citation xml:lang="en">Redfield M.M. Heart failure with preserved ejection fraction. N. Engl. J. Med. 2016;375(19):1868– 1877. doi: 10.1056/NEJMcp1511175</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Dunlay S.M., Roger V.L., Redfield M.M. Epidemiology of heart failure with preserved ejection fraction. Nat. Rev. Cardiol. 2017;14(10):591–602. doi: 10.1038/nrcardio.2017.65</mixed-citation><mixed-citation xml:lang="en">Dunlay S.M., Roger V.L., Redfield M.M. Epidemiology of heart failure with preserved ejection fraction. Nat. Rev. Cardiol. 2017;14(10):591–602. doi: 10.1038/nrcardio.2017.65</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Цыганкова О.В., Веретюк В.В. Фенотипические кластеры пациентов с хронической сердечной недостаточностью с сохраненной и промежуточной фракцией выброса: новые данные и перспективы. Рос. кардиол. ж. 2021;26(4):4436. doi: 10.15829/1560-4071-2021-4436 Tsygankova O.V., Veretyuk V.V. Phenotypic clusters in heart failure with preserved and mid-range ejection fraction: new data and perspectives. Rossiyskiy kardiologicheskiy zhurnal = Russian Journal of Cardiology. 2021;26(4):4436. [In Russian]. doi: 10.15829/1560- 4071-2021-4436</mixed-citation><mixed-citation xml:lang="en">Цыганкова О.В., Веретюк В.В. Фенотипические кластеры пациентов с хронической сердечной недостаточностью с сохраненной и промежуточной фракцией выброса: новые данные и перспективы. Рос. кардиол. ж. 2021;26(4):4436. doi: 10.15829/1560-4071-2021-4436 Tsygankova O.V., Veretyuk V.V. Phenotypic clusters in heart failure with preserved and mid-range ejection fraction: new data and perspectives. Rossiyskiy kardiologicheskiy zhurnal = Russian Journal of Cardiology. 2021;26(4):4436. [In Russian]. doi: 10.15829/1560- 4071-2021-4436</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Цыганкова О.В., Веретюк В.В., Мареев В.Ю. Возможности положительной модификации кардиометаболического профиля при совместном назначении ангиотензиновых рецепторов-неприлизина ингибитора и эмпаглифлозина у коморбидных пациентов с хронической сердечной недостаточностью и сахарным диабетом 2 типа. Кардиология. 2020;60(5):146–152. doi: 10.18087/cardio.2020.5.n840 Tsygankova O.V., Veretyuk V.V., Mareev V.Yu. Modification of the of the cardiometabolic profile using combined therapy of the angiotensin receptor-neprilysin inhibitor and empagliflozin in comorbid patients with chronic heart failure and type 2 diabetes mellitus. Kardiologiya = Cardiology. 2020;60(5):146–152. [In Russian]. doi: 10.18087/cardio.2020.5.n840</mixed-citation><mixed-citation xml:lang="en">Цыганкова О.В., Веретюк В.В., Мареев В.Ю. Возможности положительной модификации кардиометаболического профиля при совместном назначении ангиотензиновых рецепторов-неприлизина ингибитора и эмпаглифлозина у коморбидных пациентов с хронической сердечной недостаточностью и сахарным диабетом 2 типа. Кардиология. 2020;60(5):146–152. doi: 10.18087/cardio.2020.5.n840 Tsygankova O.V., Veretyuk V.V., Mareev V.Yu. Modification of the of the cardiometabolic profile using combined therapy of the angiotensin receptor-neprilysin inhibitor and empagliflozin in comorbid patients with chronic heart failure and type 2 diabetes mellitus. Kardiologiya = Cardiology. 2020;60(5):146–152. [In Russian]. doi: 10.18087/cardio.2020.5.n840</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Maggioni A.P., Dahlström U., Filippatos G., Chioncel O., Crespo Leiro M., Drozdz J., Fruhwald F., Gullestad L., Logeart D., Fabbri G., … Heart Failure Association of the European Society of Cardiology (HFA). EURObservational Research Programme: regional differences and 1-year follow-up results of the Heart Failure Pilot Survey (ESC-HF Pilot). Eur. J. Heart Fail. 2013;15(7):808–817. doi: 10.1093/eurjhf/ hft050</mixed-citation><mixed-citation xml:lang="en">Maggioni A.P., Dahlström U., Filippatos G., Chioncel O., Crespo Leiro M., Drozdz J., Fruhwald F., Gullestad L., Logeart D., Fabbri G., … Heart Failure Association of the European Society of Cardiology (HFA). EURObservational Research Programme: regional differences and 1-year follow-up results of the Heart Failure Pilot Survey (ESC-HF Pilot). Eur. J. Heart Fail. 2013;15(7):808–817. doi: 10.1093/eurjhf/ hft050</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Pabel S., Hamdan N., Singh J., Sossalla S. Potential mechanisms of SGLT2 inhibitors for the treatment of heart failure with preserved ejection fraction. Front. Physiol. 2021;12:752370. doi: 10.3389/ fphys.2021.752370</mixed-citation><mixed-citation xml:lang="en">Pabel S., Hamdan N., Singh J., Sossalla S. Potential mechanisms of SGLT2 inhibitors for the treatment of heart failure with preserved ejection fraction. Front. Physiol. 2021;12:752370. doi: 10.3389/ fphys.2021.752370</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">McMurray J., Solomon S.D., Inzucchi S.E., Køber L., Kosiborod M.N., Martinez F.A., Ponikowski P., Sabatine M.S., Anand I.S., Bělohlávek J., … DAPA-HF Trial Committees and Investigators. Dapagliflozin in patients with heart failure and reduced ejection fraction. N. Engl. J. Med. 2019;381(21):1995–2008. doi: 10.1056/NEJMoa1911303</mixed-citation><mixed-citation xml:lang="en">McMurray J., Solomon S.D., Inzucchi S.E., Køber L., Kosiborod M.N., Martinez F.A., Ponikowski P., Sabatine M.S., Anand I.S., Bělohlávek J., … DAPA-HF Trial Committees and Investigators. Dapagliflozin in patients with heart failure and reduced ejection fraction. N. Engl. J. Med. 2019;381(21):1995–2008. doi: 10.1056/NEJMoa1911303</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">McDonagh T.A., Metra M., Adamo M., Gardner R.S., Baumbach A., Böhm M., Burri H., Butler J., Čelutkienė J., Chioncel O., … ESC Scientific Document Group. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur. Heart J. 2021;42(36):3599–3726. doi: 10.1093/eurheartj/ehab368</mixed-citation><mixed-citation xml:lang="en">McDonagh T.A., Metra M., Adamo M., Gardner R.S., Baumbach A., Böhm M., Burri H., Butler J., Čelutkienė J., Chioncel O., … ESC Scientific Document Group. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur. Heart J. 2021;42(36):3599–3726. doi: 10.1093/eurheartj/ehab368</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Cosentino F., Grant P.J., Aboyans V., Bailey C.J., Ceriello A., Delgado V., Federici M., Filippatos G., Grobbee D.E., Hansen T.B., … ESC Scientific Document Group. 2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD. Eur. Heart J. 2020;41(2):255–323. doi: 10.1093/eurheartj/ehz486</mixed-citation><mixed-citation xml:lang="en">Cosentino F., Grant P.J., Aboyans V., Bailey C.J., Ceriello A., Delgado V., Federici M., Filippatos G., Grobbee D.E., Hansen T.B., … ESC Scientific Document Group. 2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD. Eur. Heart J. 2020;41(2):255–323. doi: 10.1093/eurheartj/ehz486</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Anker S.D., Butler J., Filippatos G., Ferreira J.P., Bocchi E., Böhm M., Brunner-La Rocca H.P., Choi D.J., Chopra V., Chuquiure-Valenzuela E., … EMPEROR-Preserved Trial Investigators. Empagliflozin in heart failure with a preserved ejection fraction. N. Engl. J. Med. 2021;385(16):1451–1461. doi: 10.1056/ NEJMoa2107038</mixed-citation><mixed-citation xml:lang="en">Anker S.D., Butler J., Filippatos G., Ferreira J.P., Bocchi E., Böhm M., Brunner-La Rocca H.P., Choi D.J., Chopra V., Chuquiure-Valenzuela E., … EMPEROR-Preserved Trial Investigators. Empagliflozin in heart failure with a preserved ejection fraction. N. Engl. J. Med. 2021;385(16):1451–1461. doi: 10.1056/ NEJMoa2107038</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Solomon S.D., McMurray J.J.V., Claggett B., de Boer R.A., DeMets D., Hernandez A.F., Inzucchi S.E., Kosiborod M.N., Lam C.S.P., Martinez F., … DELIVER Trial Committees and Investigators. Dapagliflozin in heart failure with mildly reduced or preserved ejection fraction. N. Engl. J. Med. 2022;387(12):1089– 1098. doi: 10.1056/NEJMoa2206286</mixed-citation><mixed-citation xml:lang="en">Solomon S.D., McMurray J.J.V., Claggett B., de Boer R.A., DeMets D., Hernandez A.F., Inzucchi S.E., Kosiborod M.N., Lam C.S.P., Martinez F., … DELIVER Trial Committees and Investigators. Dapagliflozin in heart failure with mildly reduced or preserved ejection fraction. N. Engl. J. Med. 2022;387(12):1089– 1098. doi: 10.1056/NEJMoa2206286</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Tridetti J., Nguyen Trung M.L., Ancion A., Lancellotti P. The PARAGON-HF trial. Rev. Med. Liege. 2020;75(2):130–135. [In French].</mixed-citation><mixed-citation xml:lang="en">Tridetti J., Nguyen Trung M.L., Ancion A., Lancellotti P. The PARAGON-HF trial. Rev. Med. Liege. 2020;75(2):130–135. [In French].</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Packer M., Butler J., Zannad F., Filippatos G., Ferreira J.P., Pocock S.J., Carson P., Anand I., Doehner W., Haass M., … Anker S.D. Effect of empagliflozin on worsening heart failure events in patients with heart failure and preserved ejection fraction: EMPERORpreserved trial. Circulation. 2021;144(16):1284–1294. doi: 10.1161/CIRCULATIONAHA.121.056824</mixed-citation><mixed-citation xml:lang="en">Packer M., Butler J., Zannad F., Filippatos G., Ferreira J.P., Pocock S.J., Carson P., Anand I., Doehner W., Haass M., … Anker S.D. Effect of empagliflozin on worsening heart failure events in patients with heart failure and preserved ejection fraction: EMPERORpreserved trial. Circulation. 2021;144(16):1284–1294. doi: 10.1161/CIRCULATIONAHA.121.056824</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Madaan T., Akhtar M., Najmi A.K. Sodium glucose CoTransporter 2 (SGLT2) inhibitors: Current status and future perspective. Eur. J. Pharm. Sci. 2016;93:244–252. doi: 10.1016/j.ejps.2016.08.025</mixed-citation><mixed-citation xml:lang="en">Madaan T., Akhtar M., Najmi A.K. Sodium glucose CoTransporter 2 (SGLT2) inhibitors: Current status and future perspective. Eur. J. Pharm. Sci. 2016;93:244–252. doi: 10.1016/j.ejps.2016.08.025</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Gladden J.D., Linke W.A., Redfield M. Heart failure with preserved ejection fraction. Pflugers. Arch. 2014;466(6):1037–1053. doi: 10.1007/s00424-014- 1480-8</mixed-citation><mixed-citation xml:lang="en">Gladden J.D., Linke W.A., Redfield M. Heart failure with preserved ejection fraction. Pflugers. Arch. 2014;466(6):1037–1053. doi: 10.1007/s00424-014- 1480-8</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Kosiborod M.N., Jhund P.S., Docherty K.F., Diez M., Petrie M.C., Verma S., Nicolau J.C., Merkely B., Kitakaze M., DeMets D.L., … McMurray J.J.V. Effects of dapagliflozin on symptoms, function, and quality of life in patients with heart failure and reduced ejection fraction: Results from the DAPA-HF Trial. Circulation. 2020;141(2):90–99. doi: 10.1161/CIRCULATIONAHA.119.044138</mixed-citation><mixed-citation xml:lang="en">Kosiborod M.N., Jhund P.S., Docherty K.F., Diez M., Petrie M.C., Verma S., Nicolau J.C., Merkely B., Kitakaze M., DeMets D.L., … McMurray J.J.V. Effects of dapagliflozin on symptoms, function, and quality of life in patients with heart failure and reduced ejection fraction: Results from the DAPA-HF Trial. Circulation. 2020;141(2):90–99. doi: 10.1161/CIRCULATIONAHA.119.044138</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Heidenreich P.A., Bozkurt B., Aguilar D., Allen L.A., Byun J.J., Colvin M.M., Deswal A., Drazner M.H., Dunlay S.M., Evers L.R., … Yancy C.W. 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure: A report of the American College of Cardiology / American Heart Association Joint Committee on clinical practice guidelines. Circulation. 2022;145(18):e895–e1032. doi: 10.1161/ CIR.0000000000001063</mixed-citation><mixed-citation xml:lang="en">Heidenreich P.A., Bozkurt B., Aguilar D., Allen L.A., Byun J.J., Colvin M.M., Deswal A., Drazner M.H., Dunlay S.M., Evers L.R., … Yancy C.W. 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure: A report of the American College of Cardiology / American Heart Association Joint Committee on clinical practice guidelines. Circulation. 2022;145(18):e895–e1032. doi: 10.1161/ CIR.0000000000001063</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">McDonagh T.A., Metra M., Adamo M., Gardner R.S., Baumbach A., Böhm M., Burri H., Butler J., Čelutkienė J., Chioncel O., … ESC Scientific Document Group. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur. Heart. J. 2021;42(36):3599–3726. doi: 10.1093/eurheartj/ehab368</mixed-citation><mixed-citation xml:lang="en">McDonagh T.A., Metra M., Adamo M., Gardner R.S., Baumbach A., Böhm M., Burri H., Butler J., Čelutkienė J., Chioncel O., … ESC Scientific Document Group. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur. Heart. J. 2021;42(36):3599–3726. doi: 10.1093/eurheartj/ehab368</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Wheeler D.C., Stefánsson B.V., Jongs N., Chertow G.M., Greene T., Hou F.F., McMurray J.J.V., Correa-Rotter R., Rossing P., Toto R.D., Sjöström C.D., Langkilde A.M., Heerspink H.J.L.; DAPA-CKD Trial Committees and Investigators. Effects of dapagliflozin on major adverse kidney and cardiovascular events in patients with diabetic and non-diabetic chronic kidney disease: a prespecified analysis from the DAPA-CKD trial. Lancet Diabetes Endocrinol. 2021;9(1):22–31. doi: 10.1016/S2213-8587(20)30369-7</mixed-citation><mixed-citation xml:lang="en">Wheeler D.C., Stefánsson B.V., Jongs N., Chertow G.M., Greene T., Hou F.F., McMurray J.J.V., Correa-Rotter R., Rossing P., Toto R.D., Sjöström C.D., Langkilde A.M., Heerspink H.J.L.; DAPA-CKD Trial Committees and Investigators. Effects of dapagliflozin on major adverse kidney and cardiovascular events in patients with diabetic and non-diabetic chronic kidney disease: a prespecified analysis from the DAPA-CKD trial. Lancet Diabetes Endocrinol. 2021;9(1):22–31. doi: 10.1016/S2213-8587(20)30369-7</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Franklin J.M., Patorno E., Desai R.J., Glynn R.J., Martin D., Quinto K., Pawar A., Bessette L.G., Lee H., Garry E.M., Gautam N., Schneeweiss S. Emulating randomized clinical trials with nonrandomized real-world evidence studies: First results from the RCT DUPLICATE initiative. Circulation. 2021;143(10):1002– 1013. doi: 10.1161/CIRCULATIONAHA.120.051718</mixed-citation><mixed-citation xml:lang="en">Franklin J.M., Patorno E., Desai R.J., Glynn R.J., Martin D., Quinto K., Pawar A., Bessette L.G., Lee H., Garry E.M., Gautam N., Schneeweiss S. Emulating randomized clinical trials with nonrandomized real-world evidence studies: First results from the RCT DUPLICATE initiative. Circulation. 2021;143(10):1002– 1013. doi: 10.1161/CIRCULATIONAHA.120.051718</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Wong A.K., AlZadjali M.A., Choy A.M., Lang C.C. Insulin resistance: A potential new target for therapy in patients with heart failure. Cardiovasc. Ther. 2008;26(3):203–213. doi: 10.1111/j.1755- 5922.2008.00053.x</mixed-citation><mixed-citation xml:lang="en">Wong A.K., AlZadjali M.A., Choy A.M., Lang C.C. Insulin resistance: A potential new target for therapy in patients with heart failure. Cardiovasc. Ther. 2008;26(3):203–213. doi: 10.1111/j.1755- 5922.2008.00053.x</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Scheen A.J. Beneficial effects of SGLT2 inhibitors on fatty liver in type 2 diabetes: A common comorbidity associated with severe complications. Diabetes Metab. 2019;45(3):213–223. doi: 10.1016/j. diabet.2019.01.008</mixed-citation><mixed-citation xml:lang="en">Scheen A.J. Beneficial effects of SGLT2 inhibitors on fatty liver in type 2 diabetes: A common comorbidity associated with severe complications. Diabetes Metab. 2019;45(3):213–223. doi: 10.1016/j. diabet.2019.01.008</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Цыганкова О.В., Бадин А.Р., Старичков А.А., Ложкина Н.Г. Неалкогольная жировая болезнь печени – болезнь цивилизации или синдром современности? Рос. мед. ж. Медицинское обозрение. 2018;2(3):23–28. Tsygankova O.V., Badin A.R., Starichkov A.A., Lozhkina N.G. Non-alcoholic fatty liver disease – a disease of civilization or a syndrome of modernity? Rossiyskiy meditsinskiy zhurnal. Meditsinskoye obozreniye = Medical Journal of the Russian Federation. Medical Review. 2018;2(3):23–28. [In Russian].</mixed-citation><mixed-citation xml:lang="en">Цыганкова О.В., Бадин А.Р., Старичков А.А., Ложкина Н.Г. Неалкогольная жировая болезнь печени – болезнь цивилизации или синдром современности? Рос. мед. ж. Медицинское обозрение. 2018;2(3):23–28. Tsygankova O.V., Badin A.R., Starichkov A.A., Lozhkina N.G. Non-alcoholic fatty liver disease – a disease of civilization or a syndrome of modernity? Rossiyskiy meditsinskiy zhurnal. Meditsinskoye obozreniye = Medical Journal of the Russian Federation. Medical Review. 2018;2(3):23–28. [In Russian].</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Perseghin G. Viewpoints on the way to a consensus session: where does insulin resistance start? Diabetes Care. 2009;32 (Suppl. 2):164–167. doi: 10.2337/ dc09-S303</mixed-citation><mixed-citation xml:lang="en">Perseghin G. Viewpoints on the way to a consensus session: where does insulin resistance start? Diabetes Care. 2009;32 (Suppl. 2):164–167. doi: 10.2337/ dc09-S303</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Романцова Т.И., Островская Е.В. Метаболически здоровое ожирение: дефиниции, протективные факторы, клиническая значимость. Альм. клин. мед. 2015;1(1):75–86. doi: 10.18786/2072-0505- 2015-1-75-86 Romantsova T.I., Ostrovskaya E.V. Metabolically healthy obesity: definitions, protective factors, clinical relevance. Al’manakh klinicheskoy meditsiny = Almanac of Clinical Medicine. 2015;1(1):75–86. [In Russian]. doi: 10.18786/2072-0505-2015-1-75-86</mixed-citation><mixed-citation xml:lang="en">Романцова Т.И., Островская Е.В. Метаболически здоровое ожирение: дефиниции, протективные факторы, клиническая значимость. Альм. клин. мед. 2015;1(1):75–86. doi: 10.18786/2072-0505- 2015-1-75-86 Romantsova T.I., Ostrovskaya E.V. Metabolically healthy obesity: definitions, protective factors, clinical relevance. Al’manakh klinicheskoy meditsiny = Almanac of Clinical Medicine. 2015;1(1):75–86. [In Russian]. doi: 10.18786/2072-0505-2015-1-75-86</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Latva-Rasku A., Honka M.J., Kullberg J., Mononen N., Lehtimäki T., Saltevo J., Kirjavainen A.K., Saunavaara V., Iozzo P., Johansson L., … Nuutila P. The SGLT2 inhibitor dapagliflozin reduces liver fat but does not affect tissue insulin sensitivity: A randomized, double-blind, placebo-controlled study with 8-week treatment in type 2 diabetes patients. Diabetes Care. 2019;42(5):931–937. doi: 10.2337/dc18-1569</mixed-citation><mixed-citation xml:lang="en">Latva-Rasku A., Honka M.J., Kullberg J., Mononen N., Lehtimäki T., Saltevo J., Kirjavainen A.K., Saunavaara V., Iozzo P., Johansson L., … Nuutila P. The SGLT2 inhibitor dapagliflozin reduces liver fat but does not affect tissue insulin sensitivity: A randomized, double-blind, placebo-controlled study with 8-week treatment in type 2 diabetes patients. Diabetes Care. 2019;42(5):931–937. doi: 10.2337/dc18-1569</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Aso Y., Kato K., Sakurai S., Kishi H., Shimizu M., Jojima T., Iijima T., Maejima Y., Shimomura K., Usui I. Impact of dapagliflozin, an SGLT2 inhibitor, on serum levels of soluble dipeptidyl peptidase-4 in patients with type 2 diabetes and non-alcoholic fatty liver disease. Int. J. Clin. Pract. 2019;73(5):e13335. doi: 10.1111/ijcp.13335</mixed-citation><mixed-citation xml:lang="en">Aso Y., Kato K., Sakurai S., Kishi H., Shimizu M., Jojima T., Iijima T., Maejima Y., Shimomura K., Usui I. Impact of dapagliflozin, an SGLT2 inhibitor, on serum levels of soluble dipeptidyl peptidase-4 in patients with type 2 diabetes and non-alcoholic fatty liver disease. Int. J. Clin. Pract. 2019;73(5):e13335. doi: 10.1111/ijcp.13335</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Kahl S., Gancheva S., Straßburger K., Herder C., Machann J., Katsuyama H., Kabisch S., Henkel E., Kopf S., Lagerpusch M., … Roden M. Empagliflozin effectively lowers liver fat content in well-controlled type 2 diabetes: A randomized, double-blind, phase 4, placebo-controlled trial. Diabetes Care. 2020;43(2):298–305. doi: 10.2337/dc19-0641</mixed-citation><mixed-citation xml:lang="en">Kahl S., Gancheva S., Straßburger K., Herder C., Machann J., Katsuyama H., Kabisch S., Henkel E., Kopf S., Lagerpusch M., … Roden M. Empagliflozin effectively lowers liver fat content in well-controlled type 2 diabetes: A randomized, double-blind, phase 4, placebo-controlled trial. Diabetes Care. 2020;43(2):298–305. doi: 10.2337/dc19-0641</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Filipovic B., Lukic S., Mijac D., Marjanovic-Haljilji M., Vojnovic M., Bogdanovic J., Glisic T., Filipovic N., Al Kiswani J., Djokovic A., … Starcevic A. The new therapeutic approaches in the treatment of non-alcoholic fatty liver disease. Int. J. Mol. Sci. 2021;22:13219. doi: 10.3390/ijms222413219</mixed-citation><mixed-citation xml:lang="en">Filipovic B., Lukic S., Mijac D., Marjanovic-Haljilji M., Vojnovic M., Bogdanovic J., Glisic T., Filipovic N., Al Kiswani J., Djokovic A., … Starcevic A. The new therapeutic approaches in the treatment of non-alcoholic fatty liver disease. Int. J. Mol. Sci. 2021;22:13219. doi: 10.3390/ijms222413219</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Sattar N., Fitchett D., Hantel S., George J.T., Zinman B. Empagliflozin is associated with improvements in liver enzymes potentially consistent with reductions in liver fat: results from randomised trials including the EMPA-REG OUTCOME® trial. Diabetologia. 2018;61(10):2155–2163. doi: 10.1007/s00125- 018-4702-3</mixed-citation><mixed-citation xml:lang="en">Sattar N., Fitchett D., Hantel S., George J.T., Zinman B. Empagliflozin is associated with improvements in liver enzymes potentially consistent with reductions in liver fat: results from randomised trials including the EMPA-REG OUTCOME® trial. Diabetologia. 2018;61(10):2155–2163. doi: 10.1007/s00125- 018-4702-3</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Ивашкин В.Т., Маевская М.В., Павлов Ч.С., Тихонов И.Н., Широкова Е.Н., Буеверов А.О., Драпкина О.М., Шульпекова Ю.О., Цуканов В.В., Маммаев С.Н., Маев И.В., Пальгова Л.К. Клинические рекомендации по диагностике и лечению неалкогольной жировой болезни печени Российского общества по изучению печени и Российской гастроэнтерологической ассоциации. Рос. ж. гастроэнтерол., гепатол., колопроктол. 2016;26(2):24–42. doi: 10.22416/1382-4376-2016-26- 2-24-42 Ivashkin V.T., Mayevskaya M.V., Pavlov Ch.S., Tikhonov I.N., Shirokova Ye.N., Buyeverov A.O., Drapkina O.M., Shulpekova Yu.O., Tsukanov V.V., Mammayev S.N., Mayev I.V., Palgova L.K. Diagnos tics and treatment of non-alcoholic fatty liver disease: clinical guidelines of the Russian Scientific Liver Society and the Russian gastroenterological association. Rossiyskiy zhurnal gastroenterologii, gepatologii, koloproktologii = Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2016;26(2):24–42. [In Russian]. doi: 10.22416/1382-4376-2016-26-2-24-42</mixed-citation><mixed-citation xml:lang="en">Ивашкин В.Т., Маевская М.В., Павлов Ч.С., Тихонов И.Н., Широкова Е.Н., Буеверов А.О., Драпкина О.М., Шульпекова Ю.О., Цуканов В.В., Маммаев С.Н., Маев И.В., Пальгова Л.К. Клинические рекомендации по диагностике и лечению неалкогольной жировой болезни печени Российского общества по изучению печени и Российской гастроэнтерологической ассоциации. Рос. ж. гастроэнтерол., гепатол., колопроктол. 2016;26(2):24–42. doi: 10.22416/1382-4376-2016-26- 2-24-42 Ivashkin V.T., Mayevskaya M.V., Pavlov Ch.S., Tikhonov I.N., Shirokova Ye.N., Buyeverov A.O., Drapkina O.M., Shulpekova Yu.O., Tsukanov V.V., Mammayev S.N., Mayev I.V., Palgova L.K. Diagnos tics and treatment of non-alcoholic fatty liver disease: clinical guidelines of the Russian Scientific Liver Society and the Russian gastroenterological association. Rossiyskiy zhurnal gastroenterologii, gepatologii, koloproktologii = Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2016;26(2):24–42. [In Russian]. doi: 10.22416/1382-4376-2016-26-2-24-42</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Lai L.L., Vethakkan S.R., Mustapha N.R., Mahadeva S., Chan W.K. Empagliflozin for the treatment of nonalcoholic steatohepatitis in patients with type 2 diabetes mellitus. Dig. Dis. Sci. 2020;65:623–631. doi: 10.1007/s10620-019-5477-1</mixed-citation><mixed-citation xml:lang="en">Lai L.L., Vethakkan S.R., Mustapha N.R., Mahadeva S., Chan W.K. Empagliflozin for the treatment of nonalcoholic steatohepatitis in patients with type 2 diabetes mellitus. Dig. Dis. Sci. 2020;65:623–631. doi: 10.1007/s10620-019-5477-1</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Cusi K., Bril F., Barb D., Polidori D., Sha S., Ghosh A., Farrell K., Sunny N.E., Kalavalapalli S., Pettus J., … Henry R.R. Effect of canagliflozin treatment on hepatic triglyceride content and glucose metabolism in patients with type 2 diabetes. Diabetes Obes. Metab. 2019;21(4):812–821. doi: 10.1111/dom.13584</mixed-citation><mixed-citation xml:lang="en">Cusi K., Bril F., Barb D., Polidori D., Sha S., Ghosh A., Farrell K., Sunny N.E., Kalavalapalli S., Pettus J., … Henry R.R. Effect of canagliflozin treatment on hepatic triglyceride content and glucose metabolism in patients with type 2 diabetes. Diabetes Obes. Metab. 2019;21(4):812–821. doi: 10.1111/dom.13584</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Ferguson D., Finck B.N. Emerging therapeutic approaches for the treatment of NAFLD and type 2 diabetes mellitus. Nat. Rev. Endocrinol. 2021;17:484–495. doi: 10.1038/s41574-021-00507-z</mixed-citation><mixed-citation xml:lang="en">Ferguson D., Finck B.N. Emerging therapeutic approaches for the treatment of NAFLD and type 2 diabetes mellitus. Nat. Rev. Endocrinol. 2021;17:484–495. doi: 10.1038/s41574-021-00507-z</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">van Deursen V.M., Urso R., Laroche C., Damman K., Dahlström U., Tavazzi L., Maggioni A.P., Voors A.A. Co-morbidities in patients with heart failure: an analysis of the European Heart Failure Pilot Survey. Eur. J. Heart Failure. 2014;16(1):103–111. doi: 10.1002/ejhf.30</mixed-citation><mixed-citation xml:lang="en">van Deursen V.M., Urso R., Laroche C., Damman K., Dahlström U., Tavazzi L., Maggioni A.P., Voors A.A. Co-morbidities in patients with heart failure: an analysis of the European Heart Failure Pilot Survey. Eur. J. Heart Failure. 2014;16(1):103–111. doi: 10.1002/ejhf.30</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Соломахина Н.И., Находнова Е.С., Беленков Ю.Н. Анемия хронических заболеваний и железодефицитная анемия: сравнительная характеристика показателей феррокинетики и их связь с воспалением у больных ХСН в пожилом и старческом возрасте. Кардиология. 2018;58(8S):58– 64. doi: 10.18087/cardio.2472 Solomakhina N.I., Nakhodnova E.S., Belenkov Yu.N. Anemia of chronic disease and iron deficiency anemia: Comparative characteristics of ferrokinetic parameters and their relationship with inflammation in late middle-aged and elderly patients with CHF. Kardiologiya = Cardiology. 2018;58(8S):58–64. [In Russian]. doi: 10.18087/cardio.2472</mixed-citation><mixed-citation xml:lang="en">Соломахина Н.И., Находнова Е.С., Беленков Ю.Н. Анемия хронических заболеваний и железодефицитная анемия: сравнительная характеристика показателей феррокинетики и их связь с воспалением у больных ХСН в пожилом и старческом возрасте. Кардиология. 2018;58(8S):58– 64. doi: 10.18087/cardio.2472 Solomakhina N.I., Nakhodnova E.S., Belenkov Yu.N. Anemia of chronic disease and iron deficiency anemia: Comparative characteristics of ferrokinetic parameters and their relationship with inflammation in late middle-aged and elderly patients with CHF. Kardiologiya = Cardiology. 2018;58(8S):58–64. [In Russian]. doi: 10.18087/cardio.2472</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Siddiqui S.W., Ashok T., Patni N., Fatima M., Lamis A., Anne K.K. Anemia and heart failure: A narrative review. Cureus. 2022;14(7):e27167. doi: 10.7759/ cureus.27167</mixed-citation><mixed-citation xml:lang="en">Siddiqui S.W., Ashok T., Patni N., Fatima M., Lamis A., Anne K.K. Anemia and heart failure: A narrative review. Cureus. 2022;14(7):e27167. doi: 10.7759/ cureus.27167</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Tomc J., Debeljak N. Molecular insights into the oxygen-sensing pathway and erythropoietin expression regulation in erythropoiesis. Int. J. Mol. Sci. 2021;22(13):7074. doi: 10.3390/ijms22137074</mixed-citation><mixed-citation xml:lang="en">Tomc J., Debeljak N. Molecular insights into the oxygen-sensing pathway and erythropoietin expression regulation in erythropoiesis. Int. J. Mol. Sci. 2021;22(13):7074. doi: 10.3390/ijms22137074</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Thomas L.W., Ashcroft M. Exploring the molecular interface between hypoxia-inducible factor signalling and mitochondria. Cell. Mol. Life Sci. 2019;76(9):1759–1777. doi: 10.1007/s00018-019- 03039-y</mixed-citation><mixed-citation xml:lang="en">Thomas L.W., Ashcroft M. Exploring the molecular interface between hypoxia-inducible factor signalling and mitochondria. Cell. Mol. Life Sci. 2019;76(9):1759–1777. doi: 10.1007/s00018-019- 03039-y</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Li Q.Y., Liu F., Tang X., Fu H., Mao J. Renoprotective role of hypoxia-inducible factors and the mechanism. Kidney Dis. (Basel). 2021;8(1):44–56. doi: 10.1159/000520141</mixed-citation><mixed-citation xml:lang="en">Li Q.Y., Liu F., Tang X., Fu H., Mao J. Renoprotective role of hypoxia-inducible factors and the mechanism. Kidney Dis. (Basel). 2021;8(1):44–56. doi: 10.1159/000520141</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang C., Zhong T., Li Y., Li X., Yuan X., Liu L., Wu W., Wu J., Wu Y., Liang R., … Zhong J. The hepatic AMPK-TET1-SIRT1 axis regulates glucose homeostasis. eLife. 2021;10:e70672. doi: 10.7554/ eLife.70672</mixed-citation><mixed-citation xml:lang="en">Zhang C., Zhong T., Li Y., Li X., Yuan X., Liu L., Wu W., Wu J., Wu Y., Liang R., … Zhong J. The hepatic AMPK-TET1-SIRT1 axis regulates glucose homeostasis. eLife. 2021;10:e70672. doi: 10.7554/ eLife.70672</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Meng X., Tan J., Li M., Song S., Miao Y., Zhang Q. Sirt1: Role under the condition of ischemia/ hypoxia. Cell Mol. Neurobiol. 2017;37(1):17–28. doi: 10.1007/s10571-016-0355-2</mixed-citation><mixed-citation xml:lang="en">Meng X., Tan J., Li M., Song S., Miao Y., Zhang Q. Sirt1: Role under the condition of ischemia/ hypoxia. Cell Mol. Neurobiol. 2017;37(1):17–28. doi: 10.1007/s10571-016-0355-2</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Packer M. Critical examination of mechanisms underlying the reduction in heart failure events with SGLT2 inhibitors: identification of a molecular link between their actions to stimulate erythrocytosis and to alleviate cellular stress. Cardiovasc. Res. 2021;117(1):74–84. doi: 10.1093/cvr/cvaa064</mixed-citation><mixed-citation xml:lang="en">Packer M. Critical examination of mechanisms underlying the reduction in heart failure events with SGLT2 inhibitors: identification of a molecular link between their actions to stimulate erythrocytosis and to alleviate cellular stress. Cardiovasc. Res. 2021;117(1):74–84. doi: 10.1093/cvr/cvaa064</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Ferrannini E., Mark M., Mayoux E. CV Protection in the EMPA-REG OUTCOME Trial: A “Thrifty Substrate” Hypothesis. Diabetes Care. 2016;39(7):1108–1114. doi: 10.2337/dc16-0330</mixed-citation><mixed-citation xml:lang="en">Ferrannini E., Mark M., Mayoux E. CV Protection in the EMPA-REG OUTCOME Trial: A “Thrifty Substrate” Hypothesis. Diabetes Care. 2016;39(7):1108–1114. doi: 10.2337/dc16-0330</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Inzucchi S.E., Zinman B., Fitchett D., Wanner C., Ferrannini E., Schumacher M., Schmoor C., Ohneberg K., Johansen O.E., George J.T., … Lachin J.M. How does empagliflozin reduce cardiovascular mortality? Insights from a mediation analysis of the EMPA-REG OUTCOME Trial. Diabetes Care. 2018;41(2):356–363. doi: 10.2337/dc17-1096</mixed-citation><mixed-citation xml:lang="en">Inzucchi S.E., Zinman B., Fitchett D., Wanner C., Ferrannini E., Schumacher M., Schmoor C., Ohneberg K., Johansen O.E., George J.T., … Lachin J.M. How does empagliflozin reduce cardiovascular mortality? Insights from a mediation analysis of the EMPA-REG OUTCOME Trial. Diabetes Care. 2018;41(2):356–363. doi: 10.2337/dc17-1096</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Sano M., Goto S. Possible mechanism of hematocrit elevation by sodium glucose cotransporter 2 inhibitors and associated beneficial renal and cardiovascular effects. Circulation. 2019;139(17):1985–1987. doi: 10.1161/CIRCULATIONAHA.118.038881</mixed-citation><mixed-citation xml:lang="en">Sano M., Goto S. Possible mechanism of hematocrit elevation by sodium glucose cotransporter 2 inhibitors and associated beneficial renal and cardiovascular effects. Circulation. 2019;139(17):1985–1987. doi: 10.1161/CIRCULATIONAHA.118.038881</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Guo M., Ding J., Li J., Wang J., Zhang T., Liu C., Huang W., Long Y., Gao C., Xu Y. SGLT2 inhibitors and risk of stroke in patients with type 2 diabetes: A systematic review and meta-analysis. Diabetes Obes. Metab. 2018;20(8):977–1982. doi: 10.1111/dom.13295</mixed-citation><mixed-citation xml:lang="en">Guo M., Ding J., Li J., Wang J., Zhang T., Liu C., Huang W., Long Y., Gao C., Xu Y. SGLT2 inhibitors and risk of stroke in patients with type 2 diabetes: A systematic review and meta-analysis. Diabetes Obes. Metab. 2018;20(8):977–1982. doi: 10.1111/dom.13295</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Mazer C.D., Hare G.M.T., Connelly P.W., Gilbert R.E., Shehata N., Quan A., Teoh H., Leiter L.A., Zinman B., Jüni P., … Verma S. Effect of empagliflozin on erythropoietin levels, iron stores and red blood cell morphology in patients with type 2 diabetes and coronary artery disease. Circulation. 2020;141(8):704–707. doi: 10.1161/circulationaha.119.044235</mixed-citation><mixed-citation xml:lang="en">Mazer C.D., Hare G.M.T., Connelly P.W., Gilbert R.E., Shehata N., Quan A., Teoh H., Leiter L.A., Zinman B., Jüni P., … Verma S. Effect of empagliflozin on erythropoietin levels, iron stores and red blood cell morphology in patients with type 2 diabetes and coronary artery disease. Circulation. 2020;141(8):704–707. doi: 10.1161/circulationaha.119.044235</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Sukhanov S., Higashi Y., Yoshida T., Mummidi S., Aroor A.R., Russell J.J., Bender S.B., de Marco V.G., Chandrasekar B. The SGLT2 inhibitor Empagliflozin attenuates interleukin-17A-induced human aortic smooth muscle cell proliferation and migration by targeting TRAF3IP2/ROS/NLRP3/Caspase1-dependent IL-1β and IL-18 secretion. Cell. Signal. 2021;77:109825. doi: 10.1016/j.cellsig.2020.109825</mixed-citation><mixed-citation xml:lang="en">Sukhanov S., Higashi Y., Yoshida T., Mummidi S., Aroor A.R., Russell J.J., Bender S.B., de Marco V.G., Chandrasekar B. The SGLT2 inhibitor Empagliflozin attenuates interleukin-17A-induced human aortic smooth muscle cell proliferation and migration by targeting TRAF3IP2/ROS/NLRP3/Caspase1-dependent IL-1β and IL-18 secretion. Cell. Signal. 2021;77:109825. doi: 10.1016/j.cellsig.2020.109825</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Ferreira J.P., Anker S.D., Butler J., Filippatos G., Iwata T., Salsali A., Zeller C., Pocock S.J., Zannad F., Packer M. Impact of anaemia and the effect of empagliflozin in heart failure with reduced ejection fraction: findings from EMPEROR-Reduced. Heart Failure. 2022;24(4):708–715. doi: 10.1002/ejhf.2409</mixed-citation><mixed-citation xml:lang="en">Ferreira J.P., Anker S.D., Butler J., Filippatos G., Iwata T., Salsali A., Zeller C., Pocock S.J., Zannad F., Packer M. Impact of anaemia and the effect of empagliflozin in heart failure with reduced ejection fraction: findings from EMPEROR-Reduced. Heart Failure. 2022;24(4):708–715. doi: 10.1002/ejhf.2409</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Docherty K.F., Curtain J.P., Anand I.S., Bengtsson O., Inzucchi S.E., Køber L., Kosiborod M.N., Langkilde A.M., Martinez F.A., Ponikowski P., … DAPA-HF Investigators and Committees. Effect of dapagliflozin on anaemia in DAPA-HF. Eur. J. Heart Fail. 2021;23(4):617–628. doi: 10.1002/ejhf.2132</mixed-citation><mixed-citation xml:lang="en">Docherty K.F., Curtain J.P., Anand I.S., Bengtsson O., Inzucchi S.E., Køber L., Kosiborod M.N., Langkilde A.M., Martinez F.A., Ponikowski P., … DAPA-HF Investigators and Committees. Effect of dapagliflozin on anaemia in DAPA-HF. Eur. J. Heart Fail. 2021;23(4):617–628. doi: 10.1002/ejhf.2132</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Luo G., Jian Z., Zhu Y., Zhu Y., Chen B., Ma R., Tang F., Xiao Y. Sirt1 promotes autophagy and inhibits apoptosis to protect cardiomyocytes from hypoxic stress. Int. J. Mol. Med. 2019;43(5):2033–2043. doi: 10.3892/ijmm.2019.4125</mixed-citation><mixed-citation xml:lang="en">Luo G., Jian Z., Zhu Y., Zhu Y., Chen B., Ma R., Tang F., Xiao Y. Sirt1 promotes autophagy and inhibits apoptosis to protect cardiomyocytes from hypoxic stress. Int. J. Mol. Med. 2019;43(5):2033–2043. doi: 10.3892/ijmm.2019.4125</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Packer M. Cardioprotective effects of sirtuin-1 and its downstream effectors: potential role in mediating the heart failure benefits of SGLT2 (sodiumglucose cotransporter 2) inhibitors. Circ. Heart. Fail. 2020;13(9):e007197. doi: 10.1161/CIRCHEARTFAILURE.120.007197</mixed-citation><mixed-citation xml:lang="en">Packer M. Cardioprotective effects of sirtuin-1 and its downstream effectors: potential role in mediating the heart failure benefits of SGLT2 (sodiumglucose cotransporter 2) inhibitors. Circ. Heart. Fail. 2020;13(9):e007197. doi: 10.1161/CIRCHEARTFAILURE.120.007197</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Umino H., Hasegawa K., Minakuchi H., Muraoka H., Kawaguchi T., Kanda T., Tokuyama H., Wak ino S., Itoh H. High basolateral glucose increases sodium-glucose cotransporter 2 and reduces sirtuin-1 in renal tubules through glucose transporter-2 detection. Sci. Rep. 2018;8(1):6791. doi: 10.1038/s41598-018- 25054-y</mixed-citation><mixed-citation xml:lang="en">Umino H., Hasegawa K., Minakuchi H., Muraoka H., Kawaguchi T., Kanda T., Tokuyama H., Wak ino S., Itoh H. High basolateral glucose increases sodium-glucose cotransporter 2 and reduces sirtuin-1 in renal tubules through glucose transporter-2 detection. Sci. Rep. 2018;8(1):6791. doi: 10.1038/s41598-018- 25054-y</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Swe M.T., Thongnak L., Jaikumkao K., Pongchaidecha A., Chatsudthipong V., Lungkaphin A. Dapagliflozin not only improves hepatic injury and pancreatic endoplasmic reticulum stress, but also induces hepatic gluconeogenic enzymes expression in obese rats. Clin. Sci. (Lond.). 2019;133(23):2415–2430. doi: 10.1042/CS20190863</mixed-citation><mixed-citation xml:lang="en">Swe M.T., Thongnak L., Jaikumkao K., Pongchaidecha A., Chatsudthipong V., Lungkaphin A. Dapagliflozin not only improves hepatic injury and pancreatic endoplasmic reticulum stress, but also induces hepatic gluconeogenic enzymes expression in obese rats. Clin. Sci. (Lond.). 2019;133(23):2415–2430. doi: 10.1042/CS20190863</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Mentz R.J., Kelly J.P., von Lueder T.G., Voors A.A., Lam C.S., Cowie M.R., Kjeldsen K., Jankowska E.A., Atar D., Butler J., … O’Connor C.M. Noncardiac comorbidities in heart failure with reduced versus preserved ejection fraction. J. Am. Coll. Cardiol. 2014;64(21):2281–2293. doi: 10.1016/j. jacc.2014.08.036</mixed-citation><mixed-citation xml:lang="en">Mentz R.J., Kelly J.P., von Lueder T.G., Voors A.A., Lam C.S., Cowie M.R., Kjeldsen K., Jankowska E.A., Atar D., Butler J., … O’Connor C.M. Noncardiac comorbidities in heart failure with reduced versus preserved ejection fraction. J. Am. Coll. Cardiol. 2014;64(21):2281–2293. doi: 10.1016/j. jacc.2014.08.036</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
