sibmedСибирский научный медицинский журналСибирский научный медицинский журнал2410-25122410-2520ИЦиГ СО РАН10.18699/SSMJ20220302sibmed-800Research ArticleОБЗОРЫREVIEWSРоль Helicobacter pylori в патогенезе некоторых гематологических заболеванийHelicobacter pylori roles in haematology disease pathogenesishttps://orcid.org/0000-0002-9809-2294ПотаповаМ. В.PotapovaM. V.

Марина Валериановна Потапова, к.м.н.

410012, г. Саратов, ул. Большая Казачья, 112

Marina V. Potapova, candidate of medical sciences

410012, Saratov, Bolshaya Kazachya str., 112

marin9@bk.ruhttps://orcid.org/0000-0002-6276-5346БроякаН. А.BroyakaN. A.

Нелли Александровна Брояка, к.м.н.

410012, г. Саратов, ул. Большая Казачья, 112

Nelli A. Broyaka, candidate of medical sciences

410012, Saratov, Bolshaya Kazachya str., 112

n.a.broyaka@mail.ruhttps://orcid.org/0000-0003-2675-0291СкворцовК. Ю.SkvortsovK. Yu.

Константин Юрьевич Скворцов, к.м.н.

410012, г. Саратов, ул. Верхний рынок, 10

Konstantin Yu. Skvortsov, candidate of medical sciences

410012, Saratov, Verkhniy Rynok, 10

kyskvortsov@gmail.comhttps://orcid.org/0000-0002-0225-3429КонобееваЕ. В.KonobeevaE. V.

Елена Владимировна Конобеева, к.м.н.

410012, г. Саратов, ул. Большая Казачья, 112

Elena V. Konobeeva, candidate of medical science

410012, Saratov, Bolshaya Kazachya str., 112

tevla@yandex.ruСаратовский государственный медицинский университет им. В.И. Разумовского Минздрава РоссииРоссияSaratov State Medical University n.a. V.I. Razumovsky of Minzdrav of RussiaRussian FederationСаратовский медицинский университет «Реавиз»РоссияSaratov Medical University «Reaviz»Russian Federation2022270620224231835Copyright © Потапова М.В., Брояка Н.А., Скворцов К.Ю., Конобеева Е.В., 20222022Потапова М.В., Брояка Н.А., Скворцов К.Ю., Конобеева Е.В.Potapova M.V., Broyaka N.A., Skvortsov K.Y., Konobeeva E.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://sibmed.elpub.ru/jour/article/view/800

Helicobacter pylori считается одной из значимых причин формирования патологии желудочно-кишечного тракта. Данные о роли хеликобактериоза в развитии внежелудочных заболеваний подтверждаются положительным эффектом эрадикационной терапии, в частности, на нормализацию картины периферической крови. Несмотря на это, многие аспекты остаются нераскрытыми. Однако несомненно, что Н. pylori при своей персистенции на желудочном эпителии создает условия для хронизации местного и системного воспаления. Целью обзора явился анализ литературных данных о роли бактериальных факторов Н. pylori в развитии железо- и В12-дефицитной анемии, а также тромбоцитопенической пурпуры, включенных Международным консенсусом в круг показаний для диагностики и лечения хеликобактерной инфекции. Материал и методы. Поиск источников литературы осуществлен с помощью баз данных PubMed, CyberLeninka, eLibrary, Google Scholar. Результаты. Работами последних лет показано вовлечение многих факторов патогенности Н. pylori в развитие анемии и тромбоцитопенической пурпуры через формирование эрозивно-язвенных поражений слизистой оболочки, гипоацидности, хронического системного воспаления и аутоиммунного ответа. Данные о связи этих изменений с гематологическими синдромами, как и о самостоятельном влиянии эрадикации на нормализацию лабораторных показателей крови, противоречивы. Не находит подтверждения теория конкуренции Н. pylori как симбионта за усвоение железа хозяина. Заключение. Представляются необходимыми дальнейшие исследования по взаимосвязи Н. pylori и заболеваний крови. Перспективно изучение и применение диетологических подходов к сохранению целостности слизевого барьера и предотвращению бактериальной адгезии.

Helicobacter pylori is considered to be one of the significant reasons of formation of gastroduodenal pathology. Data on the role of H. pylori in the development of extragastric diseases are confirmed by a positive effect of eradication on peripheral blood changes. In spite of this fact both aspects are still not revealed. However, undoubtedly that H. pylori persistence on gastric epithelium creates conditions for chronic local and systematic inflammation. The aim of the sur- vey was the analysis of literary data about bacterial factors in the development of iron-, vitamin B12-deficiency anaemia and thrombocytopenic purpura included by the international consensus into the circle of evedences for diagnosis and treatment of H. pylori. Material and methods. There was accomplished search of literature sources with the help of data bases PubMed, CyberLeninka, eLibrary, Google Scholar. The results of our analysis specify mechanisms of cer- tain blood diseases pathogenesis in association with H. pylori. Multiple roles of virulent strains of pathogen in anaemia and thrombocytopenic purpura include: development of erosive and ulcerative lesions of mucosa, hypoacidity, chron- ic inflammation and autoimmune response. Data about these changes in haematological syndromes and independent eradication effects on blood parameters normalisation, are controversial. Н. pylori host iron competition theory has not been found convincing confirmation. Conclusions. It is necessary to study more deeply the connection of H. pylori and haematological diseases. The dietary research and application to maintain the mucous integrity and bacterial adhesion prevention are perspective.

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The authors declare that there are no conflicts of interest present.