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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">sibmed</journal-id><journal-title-group><journal-title xml:lang="ru">Сибирский научный медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Сибирский научный медицинский журнал</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2410-2512</issn><issn pub-type="epub">2410-2520</issn><publisher><publisher-name>ИЦиГ СО РАН</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18699/SSMJ20220107</article-id><article-id custom-type="elpub" pub-id-type="custom">sibmed-724</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКАЯ МЕДИЦИНА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL MEDICINE</subject></subj-group></article-categories><title-group><article-title>Возрастные особенности антропометрических и биохимических характеристик мужчин из бесплодных пар</article-title><trans-title-group xml:lang="en"><trans-title>Age-related features of anthropometric and biochemical status of men from infertile couples</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9041-2687</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Епанчинцева</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Epanchintseva</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Елена Александровна Епанчинцева, к.м.н.</p><p>630117, г. Новосибирск, ул. Тимакова, 2</p><p>630037, г. Новосибирск, ул. Героев Революции, 3</p><p>630091, г. Новосибирск, Красный пр., 52</p></bio><bio xml:lang="en"><p>Elena A. Epanchintseva, candidate of medical sciences</p><p>630117, Novosibirsk, Timakov str., 2</p><p>630037, Novosibirsk, Heroes of the Revolution str., 3</p><p>630091, Novosibirsk, Krasny ave., 52</p></bio><email xlink:type="simple">epane@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8486-3185</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Янковская</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Yankovskaya</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Светлана Валерьевна Янковская</p><p>630117, г. Новосибирск, ул. Тимакова, 2</p></bio><bio xml:lang="en"><p>Svetlana V. Yankovskaya</p><p>630117, Novosibirsk, Timakov str., 2</p></bio><email xlink:type="simple">179324865@list.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4534-7289</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Селятицкая</surname><given-names>В. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Selyatitskaya</surname><given-names>V. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Вера Георгиевна Селятицкая, д.б.н., проф.</p><p>630117, г. Новосибирск, ул. Тимакова, 2</p></bio><bio xml:lang="en"><p>Vera G. Selyatitskaya, doctor of biological sciences, professor</p><p>630117, Novosibirsk, Timakov str., 2</p></bio><email xlink:type="simple">ccem@centercem.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФИЦ фундаментальной и трансляционной медицины; ООО «Новосибирский центр репродуктивной медицины» ГК «Мать и дитя»; Новосибирский государственный медицинский университет Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal Research Center of Fundamental and Translational Medicine; LLC “Novosibirsk Center of Reproductive Medicine” GC “Mother and child”; Novosibirsk State Medical University of Minzdrav of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФИЦ фундаментальной и трансляционной медицины</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal Research Center of Fundamental and Translational Medicine</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>21</day><month>02</month><year>2022</year></pub-date><volume>42</volume><issue>1</issue><fpage>62</fpage><lpage>71</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Епанчинцева Е.А., Янковская С.В., Селятицкая В.Г., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Епанчинцева Е.А., Янковская С.В., Селятицкая В.Г.</copyright-holder><copyright-holder xml:lang="en">Epanchintseva E.A., Yankovskaya S.V., Selyatitskaya V.G.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://sibmed.elpub.ru/jour/article/view/724">https://sibmed.elpub.ru/jour/article/view/724</self-uri><abstract><p>Пандемия ожирения ассоциирована со значительным ростом распространенности бесплодия в браке, включая мужское бесплодие. Ситуация с мужской фертильностью продолжает ухудшаться, что ставит вопрос о необходимости дальнейшего изучения особенностей этиологии и патогенеза мужского бесплодия. Цель исследования – изучить возрастные особенности антропометрических характеристик и метаболического статуса у мужчин из бесплодных пар. Материал и методы. Мужчины из бесплодных пар (n = 426) разделены на 5 возрастных групп: группа 1 – менее 30 лет; группы 2, 3, 4 – 30,0–34,9, 35,0–39,9, 40,0–44,9 года соответственно; группа 5 – 45 лет и старше. Проведены антропометрическое обследование и биохимический анализ крови. Результаты. Выявлено нарастание характерных возрастных изменений величин ряда изученных показателей у мужчин из бесплодных пар от группы 2 к группе 4: массы тела, индекса массы тела, окружности талии и отношения окружности талии к окружности бедер, характеризующих увеличение массы жировой ткани в абдоминальной области, частоты гипергликемии. У мужчин группы 1, несмотря на молодой возраст, величины указанных показателей оказались больше, чем у мужчин группы 2, а частоты встречаемости верхнего и нижнего типов распределения жира составили 60 и 40 % соответственно. Заключение. У молодых мужчин из бесплодных пар в возрасте до 30 лет инфертильность во многом обусловлена негативными эффектами, ассоциированными с накоплением жиро- вой ткани, как подкожной, так и висцеральной, в абдоминальной области. В последующие возрастные периоды негативные эффекты абдоминального ожирения и других медико-социальных факторов мужского бесплодия суммируются. У мужчин из бесплодных пар 40–45 лет выявлена максимально неблагоприятная ситуация по частоте встречаемости абдоминального ожирения и ассоциированных нарушений метаболического статуса.</p></abstract><trans-abstract xml:lang="en"><p>Introduction. The obesity seems to grow into a real pandemic. As one of the consequences of obesity we observe a significant increase of infertility in married couples, including male infertility. As the situation with male fertility continues to deteriorate, we consider further investigation of etiology and pathogenesis of male infertility important. Aim of the study was to investigate age-related anthropometric characteristics and metabolic status in men from infertile couples. Material and methods. 426 men from infertile couples were divided into 5 groups according to age: 1) &lt; 30 years old, 2) 30.0-34.9 years old, 3) 35.0-39,9 years old, 4) 40.0-44.9 years old, 5) ≥ 45 years old. We carried out anthropometric examination and biochemical blood analysis. Results. Within groups 2 to 4 we observed group-to- group consecutive increase in body weight, body mass index values, waist circumference and waist circumference to hip circumference values which are related to the increase of adipose tissue mass in the abdominal region. We also detected the increase of hyperglycemia occurrence. Higher values of the abovementioned anthropometric parameters were detected for the test subjects of the group 1 despite the younger age. We observed 60 and 40 % of upper and lower types of abdominal fat distribution respectively for the group 1 test subjects. Conclusions. Based on the anthropometric parameters we conclude that the infertility can be caused by negative influence of subcutaneous and visceral adipose tissue accumulation for the youngest test subjects (age &lt; 30 years). For the older test subjects, infertility results of the cumulative effect of abdominal obesity and other medical and social factors. Group 4 test subjects (age 40-45) exhibit the most frequent abdominal obesity and associated with metabolic status disorders.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>мужское бесплодие</kwd><kwd>возраст</kwd><kwd>антропометрия</kwd><kwd>абдоминальное ожирение</kwd><kwd>биохимический анализ крови.</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Клинические рекомендации «Ожирение». Общественная организация «Российская ассоциация эндокринологов», общественная организация «Общество бариатрических хирургов». 2020. Режим доступа: https://www.endocrincentr.ru/sites/default/files/specialists/science/clinic-recomendations/ozhirenie_vzroslye.pdf</mixed-citation><mixed-citation xml:lang="en">Clinical recommendations “Obesity”. Public organization “Russian Association of Endocrinologists”, public organization “Society of Bariatric Surgeons”. 2020. 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