sibmedСибирский научный медицинский журналСибирский научный медицинский журнал2410-25122410-2520ИЦиГ СО РАН10.18699/SSMJ20210109sibmed-545Research ArticleКЛИНИЧЕСКАЯ МЕДИЦИНАCLINICAL MEDICINEКачество жизни больных с полиморбидной патологиейQuality of life of patients with polymorbid pathologyhttps://orcid.org/0000-0003-1132-3801СевостьяноваЕ. В.SevostyanovaE. V.

Евгения Викторовна Cевостьянова, к.м.н.

630117, г. Новосибирск, ул. Тимакова, 2

Evgeniya V. Sevostyanova, candidate of medical sciences

630117, Novosibirsk, Timakov str., 2

luck.nsk@rambler.ruhttps://orcid.org/0000-0002-1690-6080НиколаевЮ. А.NikolaevYu. A.

Юрий Алексеевич Николаев, д.м.н.

630117, г. Новосибирск, ул. Тимакова, 2

Yury A. Nikolaev, doctor of medical sciences

630117, Novosibirsk, Timakov str., 2

nicol@centercem.ruhttps://orcid.org/0000-0003-2032-9738МитрофановИ. М.MitrofanovI. M.

Игорь Михайлович Митрофанов, д.м.н.

630117, г. Новосибирск, ул. Тимакова, 2

Igor M. Mitrofanov, doctor of medical sciences

630117, Novosibirsk, Timakov str., 2

mim@mail.ruhttps://orcid.org/0000-0002-9606-2331ПоляковВ. Я.PolyakovV. Ya.

Владимир Яковлевич Поляков, д.м.н.

630117, г. Новосибирск, ул. Тимакова, 2

Vladimir Ya. Polyakov, doctor of medical sciences

630117, Novosibirsk, Timakov str., 2

vpolyakov15@mail.ruМелиховаЮ. В.MelikhovaYu. V.

Юлия Владимировна Мелихова

630117, г. Новосибирск, ул. Тимакова, 2

Julia V. Melikhova

630117, Novosibirsk, Timakov str., 2

niiekm@yandex.ruФедеральный исследовательский центр фундаментальной и трансляционной медициныРоссияFederal Research Center of Fundamental and Translational MedicineRussian Federation2021040320214119199Copyright © Севостьянова Е.В., Николаев Ю.А., Митрофанов И.М., Поляков В.Я., Мелихова Ю.В., 20212021Севостьянова Е.В., Николаев Ю.А., Митрофанов И.М., Поляков В.Я., Мелихова Ю.В.Sevostyanova E.V., Nikolaev Y.A., Mitrofanov I.M., Polyakov V.Y., Melikhova Y.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://sibmed.elpub.ru/jour/article/view/545

Полиморбидность представляет собой актуальную проблему современной медицины, связанную с ухудшением по сравнению с изолированной патологией прогноза заболевания, увеличением тяжести течения, количества осложнений, трудности и стоимости диагностики и лечения. Изучение качества жизни (КЖ) больных с полиморбидностью необходимо для грамотного распределения ресурсов здравоохранения. Цель исследования – изучить влияние транснозологической полиморбидности (ТПМ) на компоненты КЖ у пациентов терапевтической клиники. Материал и методы. На базе клиники ФГБНУ «Федеральный исследовательский центр фундаментальной и трансляционной медицины» (г. Новосибирск) проведено обследование 116 мужчин и женщин в возрасте от 20 до 75 лет. ТПМ оценивали по среднему количеству нозологий, соответствующих трехзначной рубрификации МКБ-10, показатели КЖ – с применением валидизированного опросника SF-36. Для анализа количества и тяжести хронических заболеваний в структуре полиморбидности использовали систему CIRS (Cumulative Illness Rating Scale). Результаты. В зависимости от степени выраженности ТП сформировано 3 группы больных: с низким (n = 42), средним (n = 52) и высоким уровнем ТПМ (n = 22). Сравнительный анализ показал значимое уменьшение уровня физического функционирования (на 27 %), физического и психического компонентов здоровья (на 26,3 и 15,8 % соответственно), интегрального показателя КЖ (на 19,2 %) у пациентов с высоким уровнем ТПМ по сравнению с больными с низким уровнем ТПМ. Корреляционный анализ подтвердил наличие статистически значимой связи между увеличением ТПМ и снижением основных показателей КЖ. Заключение. Возрастание степени ТПМ значимо связано с уменьшением основных показателей КЖ.

Multimorbidity is an urgent problem of modern medicine, associated with a greater severity and more serious prognosis of diseases, a large number of complications, difficulty and the high cost of diagnosis and treatment. The study of the quality of life of patients with multimorbidity is necessary for the competent distribution of health resources. Aim of the study was to investigate the effect of transnozologic multimorbidity (TMM) on the components of quality of life (QoL) in patients of a therapeutic clinic. Material and methods. A total of 116 patients, men and women aged 20 to 75 years were examined at the clinic of the Federal Research Center for Fundamental and Translational Medicine in Novosibirsk. TMM was evaluated by the average number of nosologies corresponding to the three-digit classification of ICD-10. Assessment of QoL indicators was carried out using the validated questionnaire SF-36. To assess the number and severity of chronic diseases in the structure of TMM, the CIRS (Cumulative Illness Rating Scale) system was used. Results. Depending on the severity of TMM, 3 groups of patients were formed – with low (n = 42), medium (n = 52) and high TMM (n = 22). A comparative analysis of indicators of QoL, as well as TMM structure in 3 groups was carried out. A comparative analysis showed a significant decrease in the level of physical functioning (by 27 %), physical and mental health components (by 26.3 % and 15.8 %, respectively), and the integral indicator of quality of life (by 19.2 %) in patients with a high level TMM, compared with patients with low TMM. Correlation analysis confirmed the presence of a statistically significant relationship between an increase in TP and a decrease in the main indicators of QoL. Conclusion. An increase in the degree of TMM in patients is significantly associated with a decrease in the main indicators of QoL.

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The authors declare that there are no conflicts of interest present.