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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">sibmed</journal-id><journal-title-group><journal-title xml:lang="ru">Сибирский научный медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Сибирский научный медицинский журнал</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2410-2512</issn><issn pub-type="epub">2410-2520</issn><publisher><publisher-name>ИЦиГ СО РАН</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15372/SSMJ20180411</article-id><article-id custom-type="elpub" pub-id-type="custom">sibmed-52</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКАЯ МЕДИЦИНА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL MEDICINE</subject></subj-group></article-categories><title-group><article-title>ПРИМЕНЕНИЕ ФИЗИЧЕСКИХ ФАКТОРОВ С ЦЕЛЬЮ СНИЖЕНИЯ БАРЬЕРНОЙ ФУНКЦИИ ЭПИДЕРМИСА ДЛЯ ЛАЗЕРНОГО ИЗЛУЧЕНИЯ</article-title><trans-title-group xml:lang="en"><trans-title>APPLICATION OF PHYSICAL FACTORS TO REDUCE THE BARRIER FUNCTION OF EPIDERMIS FOR LASER RADIATION</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мухин</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Mukhin</surname><given-names>A. S.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Леонтьев</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Leontyev</surname><given-names>E. A.</given-names></name></name-alternatives><email xlink:type="simple">lea737@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Приволжский исследовательский медицинский университет Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Privolzhsky Research Medical University of Minzdrav of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Городская клиническая больница № 1 Минздрава Чувашии</institution><country>Россия</country></aff><aff xml:lang="en"><institution>City Clinical Hospital No. 1 of Minzdrav of Chuvashia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>20</day><month>02</month><year>2019</year></pub-date><volume>38</volume><issue>4</issue><fpage>87</fpage><lpage>91</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Мухин А.С., Леонтьев Е.А., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Мухин А.С., Леонтьев Е.А.</copyright-holder><copyright-holder xml:lang="en">Mukhin A.S., Leontyev E.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://sibmed.elpub.ru/jour/article/view/52">https://sibmed.elpub.ru/jour/article/view/52</self-uri><abstract><p>Цель исследования - определить оптимальную методику снижения барьерной функции эпидермиса кожи для увеличения глубины проникновения лазерного излучения в ткани. Материал и методы. Эксперименты проводили с полнослойными образцами кожи человека, полученными после хирургического вмешательства. Для определения глубины проникновения лазерного излучения в биологические ткани с одной стороны облучаемой ткани размещали источник лазерного излучения, с другой стороны, соосно с ним, вводили стеклянный световод. Приемником излучения был фотоэлектронный умножитель. Вместе с изменением положения световода в массиве тканей изменялась плотность светового потока. После построения кривой интенсивности излучения определяли глубину его проникновения в облучаемый образец. Нативные препараты кожи человека исследовали до и после воздействия физических факторов. Для проведения исследования применяли методы микродермабразии, лазерной абляции поверхностных слоев кожи, ионофореза и ультразвука с целью снижения барьерной функции эпидермиса кожи. После воздействия данных методов была измерена глубина проникновения лазерного излучения в ткани при прохождении излучения лазеров с длинами волн 532 и 1064 нм. Результаты и их обсуждение. Установлено, что микродермабразия и лазерная абляция рогового слоя эпидермиса снижают поглощение лазерного излучения на глубине до 2,5 мм, что позволяет значительно уменьшать мощность лазерного излучения.</p></abstract><trans-abstract xml:lang="en"><p>The purpose of the study is to determine the optimal technique for reducing the barrier function of skin epidermis to increase the laser radiation penetrating depth into tissues. Material and methods. The experiments were carried out with full-layer human skin samples obtained after surgical intervention. The source of laser radiation was placed on one side of the irradiated tissue and glass fiber was introduced coaxially with it on the other side to determine the depth of penetration of laser radiation into biological tissues. The radiation receiver was a photoelectric multiplier. The density of the light flux changed together with the change in the position of the fiber in the array of tissues., The depth of radiation penetration into the irradiated sample was determined after constructing the radiation intensity curve. The study of native preparations of human skin was carried out before and after exposure to physical factors. Methods of microdermabrasion, laser ablation of skin surface layers, ionophoresis and ultrasound were used to conduct the study in order to reduce the barrier function of skin epidermis. After these methods exposure, the depth of penetration of laser radiation into the tissue was measured during laser radiation with wavelengths of 532 and 1064 nm. Results and discussion. It has been established that microdermabrasion and laser ablation of epidermis stratum corneum reduced the absorption of laser radiation at the depth of up to 2.5 mm resulting in significant reducing the laser radiation power.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>тату</kwd><kwd>татуировочный пигмент</kwd><kwd>удаление тату</kwd><kwd>дермабразия</kwd><kwd>лазеротерапия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>tattoo</kwd><kwd>tattoo pigment</kwd><kwd>tattoo removal</kwd><kwd>dermabrasion</kwd><kwd>laser therapy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Авраменко С.В., Ступин И.В. Устройство коагуляции тканей. Пат. 95104929/14 РФ; Опубл. 27.12.1997.</mixed-citation><mixed-citation xml:lang="en">Авраменко С.В., Ступин И.В. Устройство коагуляции тканей. Пат. 95104929/14 РФ; Опубл. 27.12.1997.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Мухин А.С., Леонтьев Е.А. Деструкция поверхностного слоя эпидермиса увеличивает глубину проникновения лазерного излучения в биологические ткани // Врач-аспирант. 2017. 81. (2). 75-81.</mixed-citation><mixed-citation xml:lang="en">Мухин А.С., Леонтьев Е.А. Деструкция поверхностного слоя эпидермиса увеличивает глубину проникновения лазерного излучения в биологические ткани // Врач-аспирант. 2017. 81. (2). 75-81.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Мухин А.С., Леонтьев Е.А. Оптимизация оптико-физических характеристик селективного фототермолиза // Врач-аспирант. 2017. 83. (4). 84-90.</mixed-citation><mixed-citation xml:lang="en">Мухин А.С., Леонтьев Е.А. Оптимизация оптико-физических характеристик селективного фототермолиза // Врач-аспирант. 2017. 83. (4). 84-90.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Altshuler G., Smirnov M., Yaroslavsky I. Lattice of optical islets: a novel treatment modality in photomedicine // J. Phys. D: Appl. Phys. 2005. 38. 2732-2747.</mixed-citation><mixed-citation xml:lang="en">Altshuler G., Smirnov M., Yaroslavsky I. Lattice of optical islets: a novel treatment modality in photomedicine // J. Phys. D: Appl. Phys. 2005. 38. 2732-2747.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Bodde H.E., Roemele P.E., Star W.M. Quantification of topically delivered 5-aminolevulinic acid by lontophoresis across ex vivo human stratum corneum // Photochem. Photobiol. 2002. 75. (4). 418-423.</mixed-citation><mixed-citation xml:lang="en">Bodde H.E., Roemele P.E., Star W.M. Quantification of topically delivered 5-aminolevulinic acid by lontophoresis across ex vivo human stratum corneum // Photochem. Photobiol. 2002. 75. (4). 418-423.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Fang J.Y., Lee W.R., Shen S.C., Fang Y.P., Hu C.H. Enhancement of topical 5-aminolaevulinic acid delivery by erbium:YAG laser and microdermabrasion: a comparison with iontophoresis and electroporation // Br. J. Dermatol. 2004. 151. (1). 132-140.</mixed-citation><mixed-citation xml:lang="en">Fang J.Y., Lee W.R., Shen S.C., Fang Y.P., Hu C.H. Enhancement of topical 5-aminolaevulinic acid delivery by erbium:YAG laser and microdermabrasion: a comparison with iontophoresis and electroporation // Br. J. Dermatol. 2004. 151. (1). 132-140.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Huzaira M., Anderson R.R. Magnetite tattoos // Lasers Surg Med. 2002. 31. (2). 121-128.</mixed-citation><mixed-citation xml:lang="en">Huzaira M., Anderson R.R. Magnetite tattoos // Lasers Surg Med. 2002. 31. (2). 121-128.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Larina I.V., Evers B.M., Ashitkov T.V., Bartels C., Larin K.V., Esenaliev R.O. Enhancement of drug delivery in tumors by using interaction of nanoparticles with ultrasound radiation // Technol. Cancer Res. Treat. 2005. 4. (2). 217-226.</mixed-citation><mixed-citation xml:lang="en">Larina I.V., Evers B.M., Ashitkov T.V., Bartels C., Larin K.V., Esenaliev R.O. Enhancement of drug delivery in tumors by using interaction of nanoparticles with ultrasound radiation // Technol. Cancer Res. Treat. 2005. 4. (2). 217-226.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Mann R., Klingmuller G. Electron-microscopic investigation of tattoos in rabbit skin // Arch. Dermatol. Res. 1981. 271. (4). 367-372.</mixed-citation><mixed-citation xml:lang="en">Mann R., Klingmuller G. Electron-microscopic investigation of tattoos in rabbit skin // Arch. Dermatol. Res. 1981. 271. (4). 367-372.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">McNichols R.J., Fox M.A., Gowda A., Tuya S., Bell B., Motamedi M. Temporary dermal scatter reduction: quantitative assessment and implications for improved laser tattoo removal // Lasers Surg. Med. 2005. 36. (4). 289-296.</mixed-citation><mixed-citation xml:lang="en">McNichols R.J., Fox M.A., Gowda A., Tuya S., Bell B., Motamedi M. Temporary dermal scatter reduction: quantitative assessment and implications for improved laser tattoo removal // Lasers Surg. Med. 2005. 36. (4). 289-296.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Stumpp O.F., Welch A.J., Milner T.E., Neev J. Enhancement of transepidermal skin clearing agent delivery using a 980 nm diode laser // Lasers Surg. Med. 2005. 37. (4). 278-285.</mixed-citation><mixed-citation xml:lang="en">Stumpp O.F., Welch A.J., Milner T.E., Neev J. Enhancement of transepidermal skin clearing agent delivery using a 980 nm diode laser // Lasers Surg. Med. 2005. 37. (4). 278-285.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Timko A.L., Miller C.H., Johnson F.B., Ross E. In vitro quantitative chemical analysis of tattoo pigments // Arch. Dermatol. 2001. 137. (2). 143-147.</mixed-citation><mixed-citation xml:lang="en">Timko A.L., Miller C.H., Johnson F.B., Ross E. In vitro quantitative chemical analysis of tattoo pigments // Arch. Dermatol. 2001. 137. (2). 143-147.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Tuchin V.V., Altshuler G.B., Gavrilova A.A., Pravdin A.B., Tabatadze D., Childs J., Yaroslavsky I.V. Optical clearing of skin using flash lamp-induced enhancement of epidermal permeability // Lasers Surg. Med. 2006. 38. (9). 824-836.</mixed-citation><mixed-citation xml:lang="en">Tuchin V.V., Altshuler G.B., Gavrilova A.A., Pravdin A.B., Tabatadze D., Childs J., Yaroslavsky I.V. Optical clearing of skin using flash lamp-induced enhancement of epidermal permeability // Lasers Surg. Med. 2006. 38. (9). 824-836.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
