sibmedСибирский научный медицинский журналСибирский научный медицинский журнал2410-25122410-2520ИЦиГ СО РАН10.15372/SSMJ20200503sibmed-485Research ArticleОБЗОРЫREVIEWSВитамин D (стероидный гормон) и заболевания нервной системы (обзор литературы)Vitamin D (steroid hormone) and the nervous system diseases (literature review)https://orcid.org/0000-0002-2311-257XНовотныйД. А.NovotnyyD. A.

Денис Александрович Новотный 

630099, г. Новосибирск, ул. Серебренниковская, 42

Denis A. Novotnyy

630099, Novosibirsk, Serebrennikovskaya str., 42

hellpost@yandex.ruhttps://orcid.org/0000-0001-6547-6622ЖуковаН. Г.ZhukovaN. G.

Наталья Григорьевна Жукова, д.м.н.

634050, г. Томск, Московский тракт, 2

Natalia G. Zhukova, doctor of medical science

634050, Tomsk, Moscow highway, 2

znatali@yandex.ruhttps://orcid.org/0000-0002-6799-7613ШперлингЛ. П.ShperlingL. Р.

Лариса Павловна Шперлинг, к.м.н. 

630099, г. Новосибирск, ул. Серебренниковская, 42

Larisa P. Shperling, candidate of medical science

630099, Novosibirsk, Serebrennikovskaya str., 42

Lima.1963@mail.ruhttps://orcid.org/0000-0001-6966-1323СтоляроваВ. А.StolyarovaV. A.

Валентина Александровна Столярова, к.м.н. 

634050, г. Томск, Московский тракт, 2

Valentina A. Stolyarova, candidate of medical science

634050, Tomsk, Moscow highway, 2

walentinasto@gmail.comhttps://orcid.org/0000-0001-5679-1698ЖуковаИ. А.ZhukovaI. A.

Ирина Александровна Жукова, к.м.н. 

634050, г. Томск, Московский тракт, 2

Irina A. Zhukova, candidate of medical science

634050, Tomsk, Moscow highway, 2

irzhukova@inbox.ruhttps://orcid.org/0000-0001-8807-129XАгашеваА. Е.AgashevaA. E.

Анна Евгеньевна Агашева

634050, г. Томск, Московский тракт, 2

Anna E. Agasheva

634050, Tomsk, Moscow highway, 2

annaagaseva@gmail.comhttps://orcid.org/0000-0002-6466-4354ШтаймецС. В.ShtaimetsS. V.

Станислав Викторович Штаймец 

634050, г. Томск, Московский тракт, 2

Stanislav V. Shtaimets

634050, Tomsk, Moscow highway, 2

steinmetz_stas@mail.ruhttps://orcid.org/0000-0002-5293-330XДружининаО. А.DruzhininaO. A.

Оксана Аркадьевна Дружинина 

630099, г. Новосибирск, ул. Серебренниковская, 42

Oksana A. Druzhinina

630099, Novosibirsk, Serebrennikovskaya str., 42

oxi-novosib@mail.ruОбластной центр экстрапирамидных заболеваний с кабинетом ботулинотерапииРоссияRegional Center of Extrapyramidal Diseases with the Cabinet of Botulinum TherapyRussian FederationСибирский государственный медицинский университет Минздрава РоссииРоссияSiberian State Medical University of Minzdrav of RussiaRussian Federation2020201120204052437Copyright © Новотный Д.А., Жукова Н.Г., Шперлинг Л.П., Столярова В.А., Жукова И.А., Агашева А.Е., Штаймец С.В., Дружинина О.А., 20202020Новотный Д.А., Жукова Н.Г., Шперлинг Л.П., Столярова В.А., Жукова И.А., Агашева А.Е., Штаймец С.В., Дружинина О.А.Novotnyy D.A., Zhukova N.G., Shperling L.Р., Stolyarova V.A., Zhukova I.A., Agasheva A.E., Shtaimets S.V., Druzhinina O.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://sibmed.elpub.ru/jour/article/view/485

Представлен обзор публикаций по витамину D, его роли в развитии и патогенезе хронических заболеваний нервной системы. Предмет: зависимость развития хронических заболеваний нервной системы от уровня витамина D. Методы: поиск статей в базе данных PubMed, а также через отечественные электронные ресурсы по тегам vitamin D (витамин D), brain diseases (заболевания головного мозга), chronic nervous system diseases (хронические заболевания нервной системы), Parkinson’s disease (болезнь Паркинсона), Alzheimer’s disease (болезнь Альцгеймера), multiple sclerosis (рассеянный склероз), schizophrenia (шизофрения). Результаты. Витамин D, будучи стероидным гормоном, оказывает стимулирующее влияние на мозговую активность как у эмбриона, так и у взрослого индивида; регулирует деятельность нейронных кругов, а также двигательное и эмоциональное поведение. Низкие уровни витамина D в плазме крови обнаружены у пациентов с болезнью Паркинсона, болезнью Альцгеймера, рассеянным склерозом, шизофренией, расстройством аутистического спектра и при нарушениях сна. Обсуждение. Данные представленных современных исследований противоречивы, необходимо дальнейшее изучение значимости гиповитаминоза витамина D для манифестации хронических заболеваний нервной системы и их прогрессирования, а также эффективности препаратов витамина D у пациентов с хронической патологией нервной системы.

The present review aims to summarize the activities of vitamin D effects on the nervous system and to clarify a vitamin D role in brain diseases, in the pathogenesis or as a serum biomarker for the disease development and severity. Objective: correlation between chronic nervous system diseases and vitamin D level. Methods: a literature research in PubMed and in Russian electronic resources by keywords: vitamin D, brain diseases, chronic nervous system diseases. Results. Vitamin D as a neurosteroid hormone stimulates cerebral activity in both adult and embryonic brain regulates the activity of neural circuits which are responsible for locomotor, reward-dependent and emotional behavior. Patients with autism spectrum disorders, schizophrenia, Alzheimer disease, multiple sclerosis, Parkinson disease and sleep disorders have been shown to have low level of vitamin D. Discussion. Data are controversial, a further study of vitamin D hypovitaminosis significance is essential for the nervous system chronic diseases manifestation and evaluation of the vitamin D dietary supplement efficiency in patients with the nervous system pathology.

витамин Dзаболевания головного мозгахронические заболевания нервной системыболезнь Паркинсонаболезнь Альцгеймераvitamin Dbrain diseaseschronic nervous system diseasesParkinson’s diseaseAlzheimer’s diseaseReferencesMcCollum E.F., Simmonds N., Becker J.E., Shipley P.G., Pitz W., Bunting R.W. The effect of additions of fluorine to the diet of the rat on the quality of the teeth. 1925. Studies on experimental rickets. XXI. An experimental demonstration of the existence of a vitamin which promotes calcium deposition. 1922. The effect of additions of fluorine to the diet of the rat on the quality of the teeth. 1925. J. Biol. Chem. 2002. 277 (19): E8. doi: 10.1111/j.1753-4887.1975.tb07097.xMcCollum E.F., Simmonds N., Becker J.E., Shipley P.G., Pitz W., Bunting R.W. The effect of additions of fluorine to the diet of the rat on the quality of the teeth. 1925. Studies on experimental rickets. XXI. An experimental demonstration of the existence of a vitamin which promotes calcium deposition. 1922. The effect of additions of fluorine to the diet of the rat on the quality of the teeth. 1925. J. Biol. Chem. 2002. 277 (19): E8. doi: 10.1111/j.1753-4887.1975.tb07097.xde Luca H.F. History of the discovery of vitamin D and its active metabolites. BoneKey Reports. 2014; 3: 479. doi: 10.1038/bonekey.2013.213de Luca H.F. History of the discovery of vitamin D and its active metabolites. BoneKey Reports. 2014; 3: 479. doi: 10.1038/bonekey.2013.213Авцын А.П., Жаворонков А.А., Риш М.А., Строчкова Л.С. Микроэлементозы человека: этиология, классификация, органопатология. М.: Медицина, 1984. 495 c. Avcyn A.P., Zhavoronkov A.A., Rish M.A., Strochkova L.S. Microelementosis of human: ethiology, classification, organopathology. Moscow: Meditsina, 1984. 495 p. [In Russian].Авцын А.П., Жаворонков А.А., Риш М.А., Строчкова Л.С. Микроэлементозы человека: этиология, классификация, органопатология. М.: Медицина, 1984. 495 c. Avcyn A.P., Zhavoronkov A.A., Rish M.A., Strochkova L.S. Microelementosis of human: ethiology, classification, organopathology. Moscow: Meditsina, 1984. 495 p. [In Russian].Wang T.T., Tavera-Mendoza L.E., Laparriere D., Libby E., MacLeod N.B., Nagai Y., Bourdeau V., Konstorum A., Lallemant B., Zhang R., Mader S., White J.H. Large-scale in silico and microarray-based identification of direct 1, 25-dihydroxyvitamin D3 target genes. Mol. Endocrinol. 2005; 19: 2685–2695. doi: 10.1210/me.2005-0106Wang T.T., Tavera-Mendoza L.E., Laparriere D., Libby E., MacLeod N.B., Nagai Y., Bourdeau V., Konstorum A., Lallemant B., Zhang R., Mader S., White J.H. Large-scale in silico and microarray-based identification of direct 1, 25-dihydroxyvitamin D3 target genes. Mol. Endocrinol. 2005; 19: 2685–2695. doi: 10.1210/me.2005-0106Sharif K., Sharif Y., Watad A., Yavne Y., Lichtbroun B., Bragazzi N.L., Amital H., Shoenfeld Y. Vitamin D, autoimmunity and recurrent pregnancy loss: more than an association. Am. J. Reprod. Immunol. 2018; 80 (3): e12991. doi: 10.1111/aji.12991Sharif K., Sharif Y., Watad A., Yavne Y., Lichtbroun B., Bragazzi N.L., Amital H., Shoenfeld Y. Vitamin D, autoimmunity and recurrent pregnancy loss: more than an association. Am. J. Reprod. Immunol. 2018; 80 (3): e12991. doi: 10.1111/aji.12991Ali A., Cui X., Eyles D. Developmental vitamin D deficiency and autism: putative pathogenic mechanisms. J. Steroid Biochem. Mol. Biol. 2018; 175: 108– 118. doi:10.1016/j.jsbmb.2016.12Ali A., Cui X., Eyles D. Developmental vitamin D deficiency and autism: putative pathogenic mechanisms. J. Steroid Biochem. Mol. Biol. 2018; 175: 108– 118. doi:10.1016/j.jsbmb.2016.12Eyles D., Almeras L., Benech P., Patatian A., Mackay-Sim A., McGrath J., Féron F. Developmental vitamin D deficiency alters the expression of genes encoding mitochondrial, cytoskeletal and synaptic proteins in the adult rat brain. J. Steroid Biochem. Mol. Biol. 2007; 103 (3–5): 538–545. doi: 10.1016/j.jsbmb.2006.12.096Eyles D., Almeras L., Benech P., Patatian A., Mackay-Sim A., McGrath J., Féron F. Developmental vitamin D deficiency alters the expression of genes encoding mitochondrial, cytoskeletal and synaptic proteins in the adult rat brain. J. Steroid Biochem. Mol. Biol. 2007; 103 (3–5): 538–545. doi: 10.1016/j.jsbmb.2006.12.096Pertile R.A., Cui X., Eyles D.W. Vitamin D signaling and the differentiation of developing dopamine systems. Neuroscience. 2016; 333: 193–203. doi:10.1016/j.neuroscience.2016.07.020Pertile R.A., Cui X., Eyles D.W. Vitamin D signaling and the differentiation of developing dopamine systems. Neuroscience. 2016; 333: 193–203. doi:10.1016/j.neuroscience.2016.07.020Łukaszyk E., Bień-Barkowska K., Bień B. Cognitive functioning of geriatric patients: is hypovitaminosis d the next marker of cognitive dysfunction and dementia? Nutrients. 2018; 10 (8): E1104. doi: 10.3390/nu.10081104Łukaszyk E., Bień-Barkowska K., Bień B. Cognitive functioning of geriatric patients: is hypovitaminosis d the next marker of cognitive dysfunction and dementia? Nutrients. 2018; 10 (8): E1104. doi: 10.3390/nu.10081104Hiller A., Murchison C.F., Lobb B.M., O’Connor S., O’Connor M., Quinn J.F. A randomized, controlled pilot study of the effects of vitamin D supplementation on balance in Parkinson’s disease: does age matter? PLoS One. 2018; 13 (9): e0203637. doi: 10.1371/journal.pone.0203637Hiller A., Murchison C.F., Lobb B.M., O’Connor S., O’Connor M., Quinn J.F. A randomized, controlled pilot study of the effects of vitamin D supplementation on balance in Parkinson’s disease: does age matter? PLoS One. 2018; 13 (9): e0203637. doi: 10.1371/journal.pone.0203637Pierrot-Deseilligny C., Souberbielle J.C. Vitamin D and multiple sclerosis: an update. Mult. Scler. Relat. Disord. 2017; 14: 35–45. doi: 10.1016/j.msard.2017.03.014Pierrot-Deseilligny C., Souberbielle J.C. Vitamin D and multiple sclerosis: an update. Mult. Scler. Relat. Disord. 2017; 14: 35–45. doi: 10.1016/j.msard.2017.03.014Faurschou A., Schuster S., Kiess W., Bogh M.K., Philipsen P.A., Wulf H.C. The relation between sunscreen layer thickness and vitamin D production after ultraviolet B exposure: A randomizes clinical trial. Br. J. Dermatol. 2012; 167 (2): 391–395. doi:10.1111/j.1365-2133Faurschou A., Schuster S., Kiess W., Bogh M.K., Philipsen P.A., Wulf H.C. The relation between sunscreen layer thickness and vitamin D production after ultraviolet B exposure: A randomizes clinical trial. Br. J. Dermatol. 2012; 167 (2): 391–395. doi:10.1111/j.1365-2133Prosser D.E., Jones G. Enzymes involved in the activation and inactivation of vitamin D. Trends Biochem. Sci. 2004; 29: 664–673. doi: 10.1016/j.tibs.2004.10.005Prosser D.E., Jones G. Enzymes involved in the activation and inactivation of vitamin D. Trends Biochem. Sci. 2004; 29: 664–673. doi: 10.1016/j.tibs.2004.10.005Prosser D.E., Jones G. Enzymes involved in the activation and inactivation of vitamin D. Trends Biochem. Sci. 2004; 29 (12): 664–673. doi: 10.1016/j.tibs.2004.10.005Prosser D.E., Jones G. Enzymes involved in the activation and inactivation of vitamin D. Trends Biochem. Sci. 2004; 29 (12): 664–673. doi: 10.1016/j.tibs.2004.10.005Hewison M., Adams J.S. Extrarenal 1α-hydroxylase. In: Vitamin D. Ed. D. Feldman, J.W. Pike, J.S. Adams. San Diego: Academic Press, 2011; 777–804.Hewison M., Adams J.S. Extrarenal 1α-hydroxylase. In: Vitamin D. Ed. D. Feldman, J.W. Pike, J.S. Adams. San Diego: Academic Press, 2011; 777–804.Gil A., Plaza-Diaz J., Mesa A.D. Vitamin D: classic and novel actions. Ann. Nutr. Metab. 2018; 72: 87–95. doi: 10.1159/000486536Gil A., Plaza-Diaz J., Mesa A.D. Vitamin D: classic and novel actions. Ann. Nutr. Metab. 2018; 72: 87–95. doi: 10.1159/000486536Rochel N., Molnár F. Structural aspects of Vitamin D endocrinology. Mol. Cell. Endocrinol. 2017; 453: 22–35. doi: 10.1016/j.mce.2017.02.046Rochel N., Molnár F. Structural aspects of Vitamin D endocrinology. Mol. Cell. Endocrinol. 2017; 453: 22–35. doi: 10.1016/j.mce.2017.02.046Shoenfeld Y., Giacomelli R., Azrielant S., Berardicurti O., Reynolds J.A., Bruce I.N. Vitamin D and systemic lupus erythematosus – The hype and the hope. Autoimmun. Rev. 2018; 17 (1): 19–23. doi: 10.1016/j.autrev.2017.11.004Shoenfeld Y., Giacomelli R., Azrielant S., Berardicurti O., Reynolds J.A., Bruce I.N. Vitamin D and systemic lupus erythematosus – The hype and the hope. Autoimmun. Rev. 2018; 17 (1): 19–23. doi: 10.1016/j.autrev.2017.11.004Cui X., Gooch H., Petty A., McGrath J.J., Eyles D. Vitamin D and the brain: genomic and non-genomic actions. Mol. Cell. Endocrinol. 2017; 453: 131–143. doi: 10.1016/j.mce.2017.05.035Cui X., Gooch H., Petty A., McGrath J.J., Eyles D. Vitamin D and the brain: genomic and non-genomic actions. Mol. Cell. Endocrinol. 2017; 453: 131–143. doi: 10.1016/j.mce.2017.05.035Eyles D.W., Burne T.H., McGrath J.J. Vitamin D, effects on brain development, adult brain function and the links between low levels of vitamin D and neuropsychiatric disease. Front. Neuroendocrinol. 2013; 34 (1): 47–64. doi: 10.1016/j.yfrne.2012.07.001Eyles D.W., Burne T.H., McGrath J.J. Vitamin D, effects on brain development, adult brain function and the links between low levels of vitamin D and neuropsychiatric disease. Front. Neuroendocrinol. 2013; 34 (1): 47–64. doi: 10.1016/j.yfrne.2012.07.001Carlberg C. Genome-wide (over) view on the actions of vitamin D. Front. Physiol. 2014; 5: 167. doi: 10.3389/fphys.2014.00167Carlberg C. Genome-wide (over) view on the actions of vitamin D. Front. Physiol. 2014; 5: 167. doi: 10.3389/fphys.2014.00167Holick M.F., Binkley N.C., Bischoff-Ferrari H.A., Gordon C.M., Hanley D.A., Heaney R.P., Murad M.H., Weaver C.M., Endocrine Society. Evaluation, treatment, and prevention of vitamin D deficiency: an endocrine society clinical practice guideline. J. Clin. Endocrinol. Metab. 2011; 96 (7): 1911–1930. doi: 10.1210/jc.2011-0385Holick M.F., Binkley N.C., Bischoff-Ferrari H.A., Gordon C.M., Hanley D.A., Heaney R.P., Murad M.H., Weaver C.M., Endocrine Society. Evaluation, treatment, and prevention of vitamin D deficiency: an endocrine society clinical practice guideline. J. Clin. Endocrinol. Metab. 2011; 96 (7): 1911–1930. doi: 10.1210/jc.2011-0385Bivona G., Agnello L., Ciaccio M. Vitamin D and immunomodulation: is it time to change the reference value? Ann. Clin. Lab. Sci. 2017; 47 (4): 508–510.Bivona G., Agnello L., Ciaccio M. Vitamin D and immunomodulation: is it time to change the reference value? Ann. Clin. Lab. Sci. 2017; 47 (4): 508–510.Rahman A., Al-Taiar A., Shaban L., Al-Sabah R., Al-Harbi A., Mojiminiyi O. Plasma 25-hydroxy vitamin D is not associated with either cognitive function or academic performance in adolescents. Nutrients. 2018; 10 (9): E1197. doi: 10.3390/nu10091197Rahman A., Al-Taiar A., Shaban L., Al-Sabah R., Al-Harbi A., Mojiminiyi O. Plasma 25-hydroxy vitamin D is not associated with either cognitive function or academic performance in adolescents. Nutrients. 2018; 10 (9): E1197. doi: 10.3390/nu10091197Holick M.F. High prevalence of vitamin D inadequacy and implications for health. Mayo Clin. Proc. 2006; 81 (3): 353–373. doi: 10.4065/81.3.353Holick M.F. High prevalence of vitamin D inadequacy and implications for health. Mayo Clin. Proc. 2006; 81 (3): 353–373. doi: 10.4065/81.3.353Bichoff-Ferrari H.A., Giovannucci E., Willett W.C., Dietrich Th., Dawson-Hughes B. Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. Am. J. Clin. Nutr. 2006; 84 (1): 18–28. doi: 10.1093/ajcn/84.1.18Bichoff-Ferrari H.A., Giovannucci E., Willett W.C., Dietrich Th., Dawson-Hughes B. Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. Am. J. Clin. Nutr. 2006; 84 (1): 18–28. doi: 10.1093/ajcn/84.1.18Евсеева Г.П., Цех О.Ю., Токарева Н.С., Учакина Р.В., Ефименко М.В., Вьюшков К.К., Белова Н.В., Целых Е.Д., Супрун С.В., Козлов В.К. Обеспеченность витамином D детей и подростков Приамурья. Здоровая семья – 21 век. 2014; 4 (3): 23–35. doi: 10.12737/20121 Evseeva G.P., Tsekh O. Yu., Tokareva N. S., Uchakina R. V., Efimenko M.V., V’yushkov K.K., Belova N.V., Tselikh E.D., Suprun S.V., Kozlov V.K. Vitamin D supply of children and teenagers in Amur river region. Zdorovaya sem’ya – 21 vek = Healthy Family – 21 century. 2014; 4 (3): 23–35. [In Russian]. doi: 10.12737/20121Евсеева Г.П., Цех О.Ю., Токарева Н.С., Учакина Р.В., Ефименко М.В., Вьюшков К.К., Белова Н.В., Целых Е.Д., Супрун С.В., Козлов В.К. Обеспеченность витамином D детей и подростков Приамурья. Здоровая семья – 21 век. 2014; 4 (3): 23–35. doi: 10.12737/20121 Evseeva G.P., Tsekh O. Yu., Tokareva N. S., Uchakina R. V., Efimenko M.V., V’yushkov K.K., Belova N.V., Tselikh E.D., Suprun S.V., Kozlov V.K. Vitamin D supply of children and teenagers in Amur river region. Zdorovaya sem’ya – 21 vek = Healthy Family – 21 century. 2014; 4 (3): 23–35. [In Russian]. doi: 10.12737/20121Захарова И.Н., Боровик Т.Э., Творогова Т.М., Дмитриева Ю.А., Звонкова Н.Г. Витамин D – новый взгляд на роль в организме: учебное пособие. М.: ФГБОУ ДПО РМАПО, 2014. 104 с. Zaharova I.N., Borovik T.E., Tvorogova T.M., Dmitrieva Yu.A., Zvonkova N.G. Vitamin D – a new view on the role in the organism: Tutorial. Moscow, 2014. 104 p. [In Russian].Захарова И.Н., Боровик Т.Э., Творогова Т.М., Дмитриева Ю.А., Звонкова Н.Г. Витамин D – новый взгляд на роль в организме: учебное пособие. М.: ФГБОУ ДПО РМАПО, 2014. 104 с. Zaharova I.N., Borovik T.E., Tvorogova T.M., Dmitrieva Yu.A., Zvonkova N.G. Vitamin D – a new view on the role in the organism: Tutorial. Moscow, 2014. 104 p. [In Russian].Громова О.А., Торшин И.Ю. Витамины и минералы – между Сциллой и Харибдой. О мисконцепциях и других чудовищах. М.: МЦНМО, 2013. 693 c. Gromova O.A., Torshin I.Yu. Vitamines and minerals – between Scilla and Haribda. About misconceptions and other beasts. Moscow, 2013. 693 p. [In Russian].Громова О.А., Торшин И.Ю. Витамины и минералы – между Сциллой и Харибдой. О мисконцепциях и других чудовищах. М.: МЦНМО, 2013. 693 c. Gromova O.A., Torshin I.Yu. Vitamines and minerals – between Scilla and Haribda. About misconceptions and other beasts. Moscow, 2013. 693 p. [In Russian].Lee J.M., Smith J.R., Philipp B.L., Chen T.C., Mathieu J., Holick M.F. Vitamin D deficiency in a healthy group of mothers and new born infants. Clin. Pediatr. (Phila.). 2007; 46: 42–44. doi: 10.1177/0009922806289311Lee J.M., Smith J.R., Philipp B.L., Chen T.C., Mathieu J., Holick M.F. Vitamin D deficiency in a healthy group of mothers and new born infants. Clin. Pediatr. (Phila.). 2007; 46: 42–44. doi: 10.1177/0009922806289311Holick M.F. Vitamin D status: Measurement, interpretation, and clinical application. Ann. Epidemiol. 2009; 19 (2): 73–78. doi: 10.1016/j.annepidem.2007.12.001Holick M.F. Vitamin D status: Measurement, interpretation, and clinical application. Ann. Epidemiol. 2009; 19 (2): 73–78. doi: 10.1016/j.annepidem.2007.12.001Kumar J., Muntner P., Kaskel F.J., Hailpern S.M., Melamed M.L. Prevalence and associatiions of 25-hydroxyvitamin D deficiency in US children, NHANES 2001–2004. Pediatrics. 2009; 124: 362–370. doi: 10.1542/peds.2009-0051Kumar J., Muntner P., Kaskel F.J., Hailpern S.M., Melamed M.L. Prevalence and associatiions of 25-hydroxyvitamin D deficiency in US children, NHANES 2001–2004. Pediatrics. 2009; 124: 362–370. doi: 10.1542/peds.2009-0051Beghin L., Huybrechts I., Vicente-Rodriguez G., Henauw S.D., Gottrand F., Gonzales-Gross M., Dallongeville J., Sjostrom M., Leclercq C., Dietrich S., Castillo M., Plada M., Molnar D., Kersting M., Gilbert C.C., Moreno L.A. Main characteristics and participation rate of European adolescents included in the HELENA study. Arch. Public Health. 2012; 70 (1): 14. doi: 10.1186/0778-7367-70-14Beghin L., Huybrechts I., Vicente-Rodriguez G., Henauw S.D., Gottrand F., Gonzales-Gross M., Dallongeville J., Sjostrom M., Leclercq C., Dietrich S., Castillo M., Plada M., Molnar D., Kersting M., Gilbert C.C., Moreno L.A. Main characteristics and participation rate of European adolescents included in the HELENA study. Arch. Public Health. 2012; 70 (1): 14. doi: 10.1186/0778-7367-70-14Шишкова В.Н. Прием витамина D пожилыми людьми или женщинами в постменопаузе: обновление рекомендаций Европейского общества по клиническим и экономическим аспектам остеопороза и остеоартрита (ESCEO, 2013). Фарматека. 2013; 5-13: 39–42. Shishkova V.N. Vitamin D supplement in elder people and women in postmenopause: the renewal of European society recommendations of clinical and economical aspects of osteoporosis and octeoartritis (ESCEO, 2013). Farmateka = Pharmateca. 2013; (5-13): 39–42. [In Russian].Шишкова В.Н. Прием витамина D пожилыми людьми или женщинами в постменопаузе: обновление рекомендаций Европейского общества по клиническим и экономическим аспектам остеопороза и остеоартрита (ESCEO, 2013). Фарматека. 2013; 5-13: 39–42. Shishkova V.N. Vitamin D supplement in elder people and women in postmenopause: the renewal of European society recommendations of clinical and economical aspects of osteoporosis and octeoartritis (ESCEO, 2013). Farmateka = Pharmateca. 2013; (5-13): 39–42. [In Russian].Bouillon R. Vitamin D: From photosynthesis, metabolism and action to clinical applications. In: Endocrinology, 3rd Edition. Philadelphia: W.B. Saunders Co., 2001. 1009–1028. doi: 10.1038/nrendo.2017.31Bouillon R. Vitamin D: From photosynthesis, metabolism and action to clinical applications. In: Endocrinology, 3rd Edition. Philadelphia: W.B. Saunders Co., 2001. 1009–1028. doi: 10.1038/nrendo.2017.31Schleithoff S.S., Zittermann A., Tenderich G., Berthold H.K., Stehle P., Koerfer R. Vitamin D supplementation improves cytokine profiles in patients with congestive heart failure: A double-blind, randomized, placebo-controlled trial. Am. J. Clin. Nutr. 2006; 83: 754–759. doi: 10.1093/ajcn/83.4.754Schleithoff S.S., Zittermann A., Tenderich G., Berthold H.K., Stehle P., Koerfer R. Vitamin D supplementation improves cytokine profiles in patients with congestive heart failure: A double-blind, randomized, placebo-controlled trial. Am. J. Clin. Nutr. 2006; 83: 754–759. doi: 10.1093/ajcn/83.4.754Zhou C., Lu F., Cao K., Xu D., Goltzman D., Miao D. Calcium-independent and 1.25(OH)2D3-dependent regulation of the renin-angiotensin system in 1alpha-hydroxylase knockout mice. Kidney Int. 2008; 74: 170–179. doi: 10.1038/ki.2008.101Zhou C., Lu F., Cao K., Xu D., Goltzman D., Miao D. Calcium-independent and 1.25(OH)2D3-dependent regulation of the renin-angiotensin system in 1alpha-hydroxylase knockout mice. Kidney Int. 2008; 74: 170–179. doi: 10.1038/ki.2008.101Bodnar L.M., Catov J.M., Roberts J.M., Simhan H.N. Pregnancy obesity predicts poor vitamin D status in mothers and their neonates. J. Nutr. 2007; 137: 2437–2442. doi: 10.1093/jn/137.11.2437Bodnar L.M., Catov J.M., Roberts J.M., Simhan H.N. Pregnancy obesity predicts poor vitamin D status in mothers and their neonates. J. Nutr. 2007; 137: 2437–2442. doi: 10.1093/jn/137.11.2437Xu Z., Jing X., Li G., Sun J., Guo H., Hu Y., Sun F., Wen X., Chen F., Wang T., Lu X.P. Valproate decreases vitamin D levels in pediatric patients with epilepsy. Seizure. 2019; 71: 60–65. doi: 10.1016/j.seizure.2019.06.009Xu Z., Jing X., Li G., Sun J., Guo H., Hu Y., Sun F., Wen X., Chen F., Wang T., Lu X.P. Valproate decreases vitamin D levels in pediatric patients with epilepsy. Seizure. 2019; 71: 60–65. doi: 10.1016/j.seizure.2019.06.009Calza L., Borderi M., Granozzi B., Malosso P., Pancaldi L., Bon I., Re M.C. Vitamin D insufficiency is associated with subclinical atherosclerosis in HIV- 1-infected patients on combination antiretroviral therapy. HIV Res. Clin. Pract. 2019; 20 (6): 131–139. doi: 10.1080/25787489.2020.1724749Calza L., Borderi M., Granozzi B., Malosso P., Pancaldi L., Bon I., Re M.C. Vitamin D insufficiency is associated with subclinical atherosclerosis in HIV- 1-infected patients on combination antiretroviral therapy. HIV Res. Clin. Pract. 2019; 20 (6): 131–139. doi: 10.1080/25787489.2020.1724749Скрипникова И.А. Диагностика, лечение и профилактика дефицита витамина D. Остеопороз и остеопатии. 2012; 1: 34–37. Skripnikova I.A. Diagnosis, treatment and prevention vitamin D deficiency. Osteoporoz i osteopatii = Osteoporosis and Bone Diseases. 2012; 1: 34–37. [In Russian].Скрипникова И.А. Диагностика, лечение и профилактика дефицита витамина D. Остеопороз и остеопатии. 2012; 1: 34–37. Skripnikova I.A. Diagnosis, treatment and prevention vitamin D deficiency. Osteoporoz i osteopatii = Osteoporosis and Bone Diseases. 2012; 1: 34–37. [In Russian].Hoel D.G., Berwick M., Gruijl F.R., Holickd M.F. The risk and benefit of sun exposure. Dermatoendocrinology. 2016; 8: e1248325. doi: 10.1080/19381980.2016.1248325Hoel D.G., Berwick M., Gruijl F.R., Holickd M.F. The risk and benefit of sun exposure. Dermatoendocrinology. 2016; 8: e1248325. doi: 10.1080/19381980.2016.1248325Trinko J.R., Land B.B., Solecki B.W., Wickham R.J. Tellez L.A., Maldonado-Aviles J., de Araujo I.E., Addy N.A., DiLeone R.J. Vitamin D3: a Role in dopamine circuit regulation, dietinduced obesity, and drug consumption. eNeuro. 2016; 3 (2): ENEURO.0122–15.2016. doi: 10.1523/ENEURO.0122-15.2016Trinko J.R., Land B.B., Solecki B.W., Wickham R.J. Tellez L.A., Maldonado-Aviles J., de Araujo I.E., Addy N.A., DiLeone R.J. Vitamin D3: a Role in dopamine circuit regulation, dietinduced obesity, and drug consumption. eNeuro. 2016; 3 (2): ENEURO.0122–15.2016. doi: 10.1523/ENEURO.0122-15.2016Lin Z., Li W. The role of vitamin D and its analogs ininflammatory diseases. Curr. Top. Med. Chem. 2016; 16 (11): 1242–1261. doi: 10.2174/1568026615666150915111557Lin Z., Li W. The role of vitamin D and its analogs ininflammatory diseases. Curr. Top. Med. Chem. 2016; 16 (11): 1242–1261. doi: 10.2174/1568026615666150915111557Autier P., Mullie P., Macacu A., Dragomir M., Boniol M., Coppens K., Pizot C., Boniol M. Effect of vitamin D supplementation on non-skeletal disorders: a systematic review of meta-analyses and randomized trials. Lancet Diabetes Endocrinol. 2017; 5 (12): 986– 1004. doi: 10.1016/S2213-8587(17)30357-1Autier P., Mullie P., Macacu A., Dragomir M., Boniol M., Coppens K., Pizot C., Boniol M. Effect of vitamin D supplementation on non-skeletal disorders: a systematic review of meta-analyses and randomized trials. Lancet Diabetes Endocrinol. 2017; 5 (12): 986– 1004. doi: 10.1016/S2213-8587(17)30357-1Mak A. The impact of vitamin D on the immunopathophisiology, disease activity, and extra-muskuloskeletal manifestations of systemic erithematosus lupus. Int. J. Mol. Sci. 2018; 19 (8): E2355. doi: 10.3390/ijms19082355Mak A. The impact of vitamin D on the immunopathophisiology, disease activity, and extra-muskuloskeletal manifestations of systemic erithematosus lupus. Int. J. Mol. Sci. 2018; 19 (8): E2355. doi: 10.3390/ijms19082355Moretti R., Morelli M.E., Caruso P. Vitamin D in neurological diseases: a rational for a pathogenic impact. Int. J. Mol. Sci. 2018; 19: 2245. doi: 10.3390/ijms19082245Moretti R., Morelli M.E., Caruso P. Vitamin D in neurological diseases: a rational for a pathogenic impact. Int. J. Mol. Sci. 2018; 19: 2245. doi: 10.3390/ijms19082245Bivona G., Agnello L., Pivetti A., Milano S., Scazzone C., Lo Sasso B., Ciaccio M. Association between hypovitaminosis D and systemic sclerosis: true or fake? Clin. Chim. Acta. 2016; 458: 115–119. doi: 10.1016/j.cca.2016.04.026Bivona G., Agnello L., Pivetti A., Milano S., Scazzone C., Lo Sasso B., Ciaccio M. Association between hypovitaminosis D and systemic sclerosis: true or fake? Clin. Chim. Acta. 2016; 458: 115–119. doi: 10.1016/j.cca.2016.04.026Agnello L., Scazzone C., Lo Sasso B., Bellia C., Bivona G., Realmuto S., Brighina F., Schillaci R., Ragonese P., Salemi G., Ciaccio M. VDBP, CYP27B1 and 25-hydroxyvitamin D gene polymorphism analyses in a group of sicilian multiple sclerosis patients. Biochem. Genet. 2017; 55 (2): 183–192. doi: 10.1007/s10528-016-9783-4Agnello L., Scazzone C., Lo Sasso B., Bellia C., Bivona G., Realmuto S., Brighina F., Schillaci R., Ragonese P., Salemi G., Ciaccio M. VDBP, CYP27B1 and 25-hydroxyvitamin D gene polymorphism analyses in a group of sicilian multiple sclerosis patients. Biochem. Genet. 2017; 55 (2): 183–192. doi: 10.1007/s10528-016-9783-4Miller J.W., Harvey D.J., Beckett L.A., Green R., Tomaszewski Farias S., Reed B.R., Olichney J.M., Mungas D.M., DeCarli Ch. Vitamin D status and rates of cognitive decline in a multi-ethnic cohort of older adults. JAMA Neurol. 2015; 72 (11): 1295–1303. doi: 10.1001/jamaneurol.2015.2115Miller J.W., Harvey D.J., Beckett L.A., Green R., Tomaszewski Farias S., Reed B.R., Olichney J.M., Mungas D.M., DeCarli Ch. Vitamin D status and rates of cognitive decline in a multi-ethnic cohort of older adults. JAMA Neurol. 2015; 72 (11): 1295–1303. doi: 10.1001/jamaneurol.2015.2115Trochoutsou A.I., Kloukina V., Samitas K., Xanthou G. Vitamin D in the immune system: genomic and non-genomic actions. Mini Rev. Med. Chem. 2015; 15 (11): 953–963. doi: 10.2174/138955751566615051 9110830Trochoutsou A.I., Kloukina V., Samitas K., Xanthou G. Vitamin D in the immune system: genomic and non-genomic actions. Mini Rev. Med. Chem. 2015; 15 (11): 953–963. doi: 10.2174/138955751566615051 9110830Scazzone C., Agnello L., Ragonese P., Lo Sasso B., Bellia C., Bivona G., Schillaci R., Salemi G., Ciaccio M. Association of CYP2R1 rs10766197 with MS risk and disease progression. J. Neurosci. Res. 2018; 96 (2): 297–304. doi: 10.1002/jnr.24133Scazzone C., Agnello L., Ragonese P., Lo Sasso B., Bellia C., Bivona G., Schillaci R., Salemi G., Ciaccio M. Association of CYP2R1 rs10766197 with MS risk and disease progression. J. Neurosci. Res. 2018; 96 (2): 297–304. doi: 10.1002/jnr.24133Bivona G., Agnello L., Scazzone C., Lo Sasso B., Bellia C., Ciaccio M. Procalcitonin and community-acquired pneumonia (CAP) in children. Clin. Chim. Acta. 2015; 451 (Pt. B): 215–218. doi: 10.1016/j.cca.2015.09.031Bivona G., Agnello L., Scazzone C., Lo Sasso B., Bellia C., Ciaccio M. Procalcitonin and community-acquired pneumonia (CAP) in children. Clin. Chim. Acta. 2015; 451 (Pt. B): 215–218. doi: 10.1016/j.cca.2015.09.031Eyles D.W., Smith S., Kinobe R., Hewison M., McGrath J.J. Distribution of the vitamin D receptor and 1 alpha-hydroxylase in human brain. J. Chem. Neuroanat. 2005; 29 (1): 21–30. doi: 10.1016/j.jchemneu.2004.08.006Eyles D.W., Smith S., Kinobe R., Hewison M., McGrath J.J. Distribution of the vitamin D receptor and 1 alpha-hydroxylase in human brain. J. Chem. Neuroanat. 2005; 29 (1): 21–30. doi: 10.1016/j.jchemneu.2004.08.006De Abreu F.D.A., Eyles D., Feron F. Vitamin D, a neuro-immunomodulator: implications for neurodegenerative and autoimmune diseases. Psychoneuroendocrinology. 2009; 34 (1): 265–277. doi: 10.1016/j.psyneuen.2009.05.023De Abreu F.D.A., Eyles D., Feron F. Vitamin D, a neuro-immunomodulator: implications for neurodegenerative and autoimmune diseases. Psychoneuroendocrinology. 2009; 34 (1): 265–277. doi: 10.1016/j.psyneuen.2009.05.023Stumpf W.E., Sar M., Clark S.A., DeLuca H.F. Brain target sites for 1,25-dihydroxyvitamin D3. Science. 1982; 215 (4538): 1403–1405. doi: 10.1126/science.6977846Stumpf W.E., Sar M., Clark S.A., DeLuca H.F. Brain target sites for 1,25-dihydroxyvitamin D3. Science. 1982; 215 (4538): 1403–1405. doi: 10.1126/science.6977846Almeras L., Eyles D., Benech P., Laffite D., Villard C., Patatian A., Boucraut J., Mackay-Sim A., McGrath J., Féron F. Developmental vitamin D deficiency alters brain protein expression in the adult rat: implications for neuropsychiatric disorders. Proteomics. 2007; 7 (5): 769–780. doi: 10.1002/pmic.200600392Almeras L., Eyles D., Benech P., Laffite D., Villard C., Patatian A., Boucraut J., Mackay-Sim A., McGrath J., Féron F. Developmental vitamin D deficiency alters brain protein expression in the adult rat: implications for neuropsychiatric disorders. Proteomics. 2007; 7 (5): 769–780. doi: 10.1002/pmic.200600392Grecksch G., Rüthrich H., Höllt V., Becker A. Transient prenatal vitamin D deficiency is associated with changes of synaptic plasticity in the dentate gyrus in adult rats. Psychoneuroendocrinology. 2009; 34 (1): 258–264. doi: 10.1016/j.psyneuen.2009.07.004Grecksch G., Rüthrich H., Höllt V., Becker A. Transient prenatal vitamin D deficiency is associated with changes of synaptic plasticity in the dentate gyrus in adult rats. Psychoneuroendocrinology. 2009; 34 (1): 258–264. doi: 10.1016/j.psyneuen.2009.07.004Eyles D., Brown J., Mackay-SimA., McGrath J., Feron F. Vitamin D3 and brain development. Neuroscience. 2003; 118 (3): 641–653. doi: 10.1016/s0306-4522(03)00040-xEyles D., Brown J., Mackay-SimA., McGrath J., Feron F. Vitamin D3 and brain development. Neuroscience. 2003; 118 (3): 641–653. doi: 10.1016/s0306-4522(03)00040-xGroves N.J., McGrath J.J., Burne T.H. Vitamin D as a neurosteroid affecting the developing and adult brain. Annu. Rev. Nutr. 2014; 34: 117–141. doi: 10.1146/annurev-nutr-071813-105557Groves N.J., McGrath J.J., Burne T.H. Vitamin D as a neurosteroid affecting the developing and adult brain. Annu. Rev. Nutr. 2014; 34: 117–141. doi: 10.1146/annurev-nutr-071813-105557Gezen-Ak D., Dursun E., Yilmazer S. The effect of vitamin D treatment on nerve growth factor (NGF) release from hippocampal neurons. Arch. Neuropsychiatry. 2014; 51: 157–162. doi: 10.4274/npa.y7076Gezen-Ak D., Dursun E., Yilmazer S. The effect of vitamin D treatment on nerve growth factor (NGF) release from hippocampal neurons. Arch. Neuropsychiatry. 2014; 51: 157–162. doi: 10.4274/npa.y7076Pertile R.A.N., Cui X., Hammond L., Eyles D.W. Vitamin D regulation of GDNF/Ret signaling in dopaminergic neurons. FASEB J. 2018; 32 (2): 819–828. doi: 10.1096/fj.201700713RPertile R.A.N., Cui X., Hammond L., Eyles D.W. Vitamin D regulation of GDNF/Ret signaling in dopaminergic neurons. FASEB J. 2018; 32 (2): 819–828. doi: 10.1096/fj.201700713RBrewer L.D., Thibault V., Chen K.C., Langub M.C., Landfield P.W., Porter N.M. Vitamin D hormone confers neuroprotection in parallel with downregulation of L-type calcium channel expression in hippocampal neurons. J. Neurosci. 2001; 21 (1): 98– 108. doi: 10.1523/JNEUROSCI.21-01-00098.2001Brewer L.D., Thibault V., Chen K.C., Langub M.C., Landfield P.W., Porter N.M. Vitamin D hormone confers neuroprotection in parallel with downregulation of L-type calcium channel expression in hippocampal neurons. J. Neurosci. 2001; 21 (1): 98– 108. doi: 10.1523/JNEUROSCI.21-01-00098.2001Garcion E., Sindji L., Montero-Menei C., Andre C., Brachet P., Darcy F. Expression of inducible nitric oxide synthase during rat brain inflammation: regulation by 1,25-dihydroxyvitamin D3. Glia. 1998; 22 (3): 282–294.Garcion E., Sindji L., Montero-Menei C., Andre C., Brachet P., Darcy F. Expression of inducible nitric oxide synthase during rat brain inflammation: regulation by 1,25-dihydroxyvitamin D3. Glia. 1998; 22 (3): 282–294.Garcion E., Sindji L., Leblondel G., Brachet P., Darcy F. 1,25-dihydroxyvitamin D3 regulates the synthesis of gamma-glutamyl transpeptidase and glutathione levels in rat primary astrocytes. J Neurochem. 1999; 73 (2): 859–866. doi: 10.1046/j.1471-4159.1999.0730859.xGarcion E., Sindji L., Leblondel G., Brachet P., Darcy F. 1,25-dihydroxyvitamin D3 regulates the synthesis of gamma-glutamyl transpeptidase and glutathione levels in rat primary astrocytes. J Neurochem. 1999; 73 (2): 859–866. doi: 10.1046/j.1471-4159.1999.0730859.xKiraly S.J., Kiraly M.A., Hawe R.D., Makhani N. Vitamin D as a neuroactive substance: Review. Sci. World J. 2006; 6: 125–139. doi: 10.1100/tsw.2006.25Kiraly S.J., Kiraly M.A., Hawe R.D., Makhani N. Vitamin D as a neuroactive substance: Review. Sci. World J. 2006; 6: 125–139. doi: 10.1100/tsw.2006.25Zhang P., Rhodes J.S., Jr G.T., Perez S.D., Southey B.R., Rodriguez-Zas S.L. Brain region-dependent gene networks associated with selective breeding for increased voluntary wheel-running behavior. PLoS One. 2018; 13 (8): e0201773. doi: 10.1371/journal.pone.0201773Zhang P., Rhodes J.S., Jr G.T., Perez S.D., Southey B.R., Rodriguez-Zas S.L. Brain region-dependent gene networks associated with selective breeding for increased voluntary wheel-running behavior. PLoS One. 2018; 13 (8): e0201773. doi: 10.1371/journal.pone.0201773Stein M.S., Scherer S.C., Ladd K.S., Harrison L.C. A randomized controlled trial of high-dose vitamin D2 followed by intranasal insulin in Alzheimer’s disease. J. Alzheimers Dis. 2011; 26 (3): 477–484. doi: 10.3233/JAD-2011-110149Stein M.S., Scherer S.C., Ladd K.S., Harrison L.C. A randomized controlled trial of high-dose vitamin D2 followed by intranasal insulin in Alzheimer’s disease. J. Alzheimers Dis. 2011; 26 (3): 477–484. doi: 10.3233/JAD-2011-110149Burne T.H., Johnston A.N., McGrath J.J., Mackay-Sim A. Swimming behaviour and post-swimming activity in Vitamin D receptor knockout mice. Brain Res. Bull. 2006; 69 (1): 74–78. doi: 10.1016/j.brainresbull.2005.10.014Burne T.H., Johnston A.N., McGrath J.J., Mackay-Sim A. Swimming behaviour and post-swimming activity in Vitamin D receptor knockout mice. Brain Res. Bull. 2006; 69 (1): 74–78. doi: 10.1016/j.brainresbull.2005.10.014Okereke O.I., Singh A. The role of vitamin D in the prevention of late-life depression. J. Affect. Disord. 2016; 198: 1–14. doi: 10.1016/j.jad.2016.03.022Okereke O.I., Singh A. The role of vitamin D in the prevention of late-life depression. J. Affect. Disord. 2016; 198: 1–14. doi: 10.1016/j.jad.2016.03.022Bertone-Johnson E.R., Powers S.I., Spangler L., Larson J., Michael Y.L., Millen A.E., Bueche M.N., Salmoirago-Blotcher E., Wassertheil-Smoller S., Brunner R.L., Ockene J.K., Liu S., Manson J.E. Vitamin D supplementation and depression in the women’s health initiative calcium and vitamin D trial. Am. J. Epidemiol. 2012; 176 (1): 1–13. doi: 10.1093/aje/kwr482Bertone-Johnson E.R., Powers S.I., Spangler L., Larson J., Michael Y.L., Millen A.E., Bueche M.N., Salmoirago-Blotcher E., Wassertheil-Smoller S., Brunner R.L., Ockene J.K., Liu S., Manson J.E. Vitamin D supplementation and depression in the women’s health initiative calcium and vitamin D trial. Am. J. Epidemiol. 2012; 176 (1): 1–13. doi: 10.1093/aje/kwr482Luo X., Ou R., Dutta R., Tian Y., Xiong H., Shang H. Association between serum vitamin D levels and Parkinson’s Disease: a systematic review and meta-analysis. Front. Neurol. 2018; 9: 909. doi: 10.3389/fneur.2018.09Luo X., Ou R., Dutta R., Tian Y., Xiong H., Shang H. Association between serum vitamin D levels and Parkinson’s Disease: a systematic review and meta-analysis. Front. Neurol. 2018; 9: 909. doi: 10.3389/fneur.2018.09Luong V.Q.K., Nguyên T.H.L. Vitamin D and Parkinson’s disease. J. Neurosci. Res. 2012; 90 (12): 2227–2236. doi: 10.1002/jnr.23115Luong V.Q.K., Nguyên T.H.L. Vitamin D and Parkinson’s disease. J. Neurosci. Res. 2012; 90 (12): 2227–2236. doi: 10.1002/jnr.23115Bertone-Johnson E.R. Vitamin D and the occurrence of depression: causal association or circumstantial evidence? Nutr. Rev. 2009; 67 (8): 481–492. doi: 10.1111/j.1753-4887.2009.2.xBertone-Johnson E.R. Vitamin D and the occurrence of depression: causal association or circumstantial evidence? Nutr. Rev. 2009; 67 (8): 481–492. doi: 10.1111/j.1753-4887.2009.2.xLaughlin G.A., Kritz-Silverstein D., Bergstrom J., Reas E.T., Jassal S.K., Barrett-Connor E., McEvoy L.K. Vitamin D insufficiency and cognitive function trajectories in older adults: the rancho bernardo study. J. Alzheimers Dis. 2017; 58 (3): 871–883. doi: 10.3233/JAD-161295Laughlin G.A., Kritz-Silverstein D., Bergstrom J., Reas E.T., Jassal S.K., Barrett-Connor E., McEvoy L.K. Vitamin D insufficiency and cognitive function trajectories in older adults: the rancho bernardo study. J. Alzheimers Dis. 2017; 58 (3): 871–883. doi: 10.3233/JAD-161295Buell J.S., Dawson-Hughes B. Vitamin D and neurocognitive dysfunction: preventing «D» ecline? Mol. Aspects Med. 2008; 29 (6): 415–422. doi: 10.1016/j.mam.2008.05.001Buell J.S., Dawson-Hughes B. Vitamin D and neurocognitive dysfunction: preventing «D» ecline? Mol. Aspects Med. 2008; 29 (6): 415–422. doi: 10.1016/j.mam.2008.05.001Máčová L., Bičíková M., Ostatníková D., Hill M., Stárka L. Vitamin D neurosteroid and autism. Physiol. Res. 2017; 66 (3): 333–340. doi: 10.33549/physiolres.933721Máčová L., Bičíková M., Ostatníková D., Hill M., Stárka L. Vitamin D neurosteroid and autism. Physiol. Res. 2017; 66 (3): 333–340. doi: 10.33549/physiolres.933721Penckofer S., Byrn M., Adams W., Emanuele M.A., Mumby P.1, Kouba J., Wallis D.E. Vitamin D supplementation improves mood in women with type 2 diabetes. J. Diabetes Res. 2017; 2017: 8232863. doi: 10.1155/2017/8232863Penckofer S., Byrn M., Adams W., Emanuele M.A., Mumby P.1, Kouba J., Wallis D.E. Vitamin D supplementation improves mood in women with type 2 diabetes. J. Diabetes Res. 2017; 2017: 8232863. doi: 10.1155/2017/8232863Patrick R.P., Ames B.N. Vitamin D and the omega-3 fatty acids control serotonin synthesis and action, part 2: relevance for ADHD, bipolar disorder, schizophrenia, and impulse behavior. FASEB J. 2015; 29 (6): 2207–2222. doi: 10.1096/fj.14-268342Patrick R.P., Ames B.N. Vitamin D and the omega-3 fatty acids control serotonin synthesis and action, part 2: relevance for ADHD, bipolar disorder, schizophrenia, and impulse behavior. FASEB J. 2015; 29 (6): 2207–2222. doi: 10.1096/fj.14-268342Al-Amin M., Bradford D., Sullivan R.K.P., Kurniawan N.D., Moon Y., Han S.-H., Zalesky A., Burne T.H.J. Vitamin D deficiency is associated with reduced hippocampal volume and disrupted structural connectivity in patients with mild cognitive impairment. Hum. Brain Mapp. 2019; 40 (2): 394–406. doi: 10.1002/hbm.24380Al-Amin M., Bradford D., Sullivan R.K.P., Kurniawan N.D., Moon Y., Han S.-H., Zalesky A., Burne T.H.J. Vitamin D deficiency is associated with reduced hippocampal volume and disrupted structural connectivity in patients with mild cognitive impairment. Hum. Brain Mapp. 2019; 40 (2): 394–406. doi: 10.1002/hbm.24380Sakuma M., Kitamura K., Endo N., Ikeuchi ., Yokoseki A., Onodera O., Oinuma T., Sato K., Nakamura K., Narita I. Low serum 25-hydroxyvitamin D increases cognitive impairment in elderly people. J. Bone Miner. Metab. 2019; 37 (2): 368–375. doi:10.1007/s00774-018-0934-zSakuma M., Kitamura K., Endo N., Ikeuchi ., Yokoseki A., Onodera O., Oinuma T., Sato K., Nakamura K., Narita I. Low serum 25-hydroxyvitamin D increases cognitive impairment in elderly people. J. Bone Miner. Metab. 2019; 37 (2): 368–375. doi:10.1007/s00774-018-0934-zWang X., Zhang S., Lin F., Chu W., Yue Sh. Elevated Galectin-3 levels in the serum of patients with Alzheimer’s Disease. Am. J. Alzheimers Dis. Other. Demen. 2015; 30 (8): 729–732. doi: 10.1177/1533317513495107Wang X., Zhang S., Lin F., Chu W., Yue Sh. Elevated Galectin-3 levels in the serum of patients with Alzheimer’s Disease. Am. J. Alzheimers Dis. Other. Demen. 2015; 30 (8): 729–732. doi: 10.1177/1533317513495107Gao Q., Fan Y., Mu L.Y., Ma L., Song Z.-Q., Zhang Y.-N. S100B and ADMA in cerebral small vessel disease and cognitive dysfunction. J. Neurol. Sci. 2015; 354 (1–2): 27–32. doi: 10.1016/j.jns.2015.04.031Gao Q., Fan Y., Mu L.Y., Ma L., Song Z.-Q., Zhang Y.-N. S100B and ADMA in cerebral small vessel disease and cognitive dysfunction. J. Neurol. Sci. 2015; 354 (1–2): 27–32. doi: 10.1016/j.jns.2015.04.031Guo L.H., Alexopoulos P., Perneczky R. Hearttype fatty acid binding protein and vascular endothelial growth factor: cerebrospinal fluid biomarker candidates for Alzheimer’s disease. Eur. Arch. Psychiatry Clin. Neurosci. 2013; 263 (7): 553–560. doi: 10.1007/s00406-013-0405-4Guo L.H., Alexopoulos P., Perneczky R. Hearttype fatty acid binding protein and vascular endothelial growth factor: cerebrospinal fluid biomarker candidates for Alzheimer’s disease. Eur. Arch. Psychiatry Clin. Neurosci. 2013; 263 (7): 553–560. doi: 10.1007/s00406-013-0405-4Agnello L., Bivona G., Lo Sasso B., Scazzone C., Bazan V., Bellia C., Ciaccio M. Galectin-3 in acute coronary syndrome. Clin. Biochem. 2017; 0 (13-14): 797–803. doi: 10.1016/j.clinbiochem.2017.04.018Agnello L., Bivona G., Lo Sasso B., Scazzone C., Bazan V., Bellia C., Ciaccio M. Galectin-3 in acute coronary syndrome. Clin. Biochem. 2017; 0 (13-14): 797–803. doi: 10.1016/j.clinbiochem.2017.04.018Zinellu A., Sotgia S., Porcu P., Casu M.A., Bivona G., Chessa R., Deiana L., Carru C. Carotid restenosis is associated with plasma ADMA concentrations in carotid endarterectomy patients. Clin. Chem. Lab. Med. 2011; 49 (5): 897–901. doi: 10.1515/CCLM.2011.121Zinellu A., Sotgia S., Porcu P., Casu M.A., Bivona G., Chessa R., Deiana L., Carru C. Carotid restenosis is associated with plasma ADMA concentrations in carotid endarterectomy patients. Clin. Chem. Lab. Med. 2011; 49 (5): 897–901. doi: 10.1515/CCLM.2011.121Agnello L., Bivona G., Novo G., Scazzone C., Muratore R., Levantino P., Bellia C., Lo Sasso B., Ciaccio M. Heart-type fatty acid binding protein is a sensitive biomarker for early AMI detection in troponin negative patients: a pilot study. Scand. J. Clin. Lab. Invest. 2017; 77 (6): 428–432. doi: 10.1080/00365513.2017.1335880Agnello L., Bivona G., Novo G., Scazzone C., Muratore R., Levantino P., Bellia C., Lo Sasso B., Ciaccio M. Heart-type fatty acid binding protein is a sensitive biomarker for early AMI detection in troponin negative patients: a pilot study. Scand. J. Clin. Lab. Invest. 2017; 77 (6): 428–432. doi: 10.1080/00365513.2017.1335880Patel P., Shah J. Role of Vitamin D in amyloid clearance via LRP-1 upregulation in Alzheimer’s disease: a potential therapeutic target? J. Chem. Neuroanat. 2017; 85: 36–42. doi: 10.1016/j.jchemneu.2017.06.007Patel P., Shah J. Role of Vitamin D in amyloid clearance via LRP-1 upregulation in Alzheimer’s disease: a potential therapeutic target? J. Chem. Neuroanat. 2017; 85: 36–42. doi: 10.1016/j.jchemneu.2017.06.007Littlejohns T.J., Henley W.E., Lang I.A., Annweiler C., Beauchet O., Chaves P.H., Fried L., Kestenbaum B.R., Kuller L.H., Langa K.M., Lopez O.L., Kos K., Soni M., Llewellyn D.J. Vitamin D and the risk of dementia and Alzheimer disease. Neurology. 2014; 83 (10): 920–928. doi: 10.1212/WNL.0000000000000755Littlejohns T.J., Henley W.E., Lang I.A., Annweiler C., Beauchet O., Chaves P.H., Fried L., Kestenbaum B.R., Kuller L.H., Langa K.M., Lopez O.L., Kos K., Soni M., Llewellyn D.J. Vitamin D and the risk of dementia and Alzheimer disease. Neurology. 2014; 83 (10): 920–928. doi: 10.1212/WNL.0000000000000755Afzal S., Bojesen S.E., Nordestgaard B.G. Reduced 25-hydroxyvitamin D and risk of Alzheimer’s disease and vascular dementia. Alzheimers Dement. 2014; 10 (3): 296–302. doi: 10.1016/j.jalz.2013.05.1765Afzal S., Bojesen S.E., Nordestgaard B.G. Reduced 25-hydroxyvitamin D and risk of Alzheimer’s disease and vascular dementia. Alzheimers Dement. 2014; 10 (3): 296–302. doi: 10.1016/j.jalz.2013.05.1765Buell J.S., Dawson-Hughes B., Scott T.M., Weiner D.E., Dallal G.E., Qui W.Q., Bergethon P., Rosenberg I.H., Folstein M.F., Patz S., Bhadelia R.A., Tucker K.L. 25-Hydroxyvitamin D, dementia, and cerebrovascular pathology in elders receiving home services. Neurology. 2010; 74 (1): 18–26. doi: 10.1212/WNL.0b013e3181beecb7Buell J.S., Dawson-Hughes B., Scott T.M., Weiner D.E., Dallal G.E., Qui W.Q., Bergethon P., Rosenberg I.H., Folstein M.F., Patz S., Bhadelia R.A., Tucker K.L. 25-Hydroxyvitamin D, dementia, and cerebrovascular pathology in elders receiving home services. Neurology. 2010; 74 (1): 18–26. doi: 10.1212/WNL.0b013e3181beecb7Annweiler C., Llewellyn D.J., Beauchet O. Low serum vitamin D concentrations in Alzheimer’s disease: a systematic review and meta-analysis. J. Alzheimers Dis. 2013; 33 (3): 659–674. doi: 10.3233/JAD-2012-121432Annweiler C., Llewellyn D.J., Beauchet O. Low serum vitamin D concentrations in Alzheimer’s disease: a systematic review and meta-analysis. J. Alzheimers Dis. 2013; 33 (3): 659–674. doi: 10.3233/JAD-2012-121432Feart C., Helmer C., Merle B., Herrmann F.R., Annweiler C., Dartigues J.F., Delcourt C., Samieri C. Associations of lower vitamin D concentrations with cognitive decline and long-term risk of dementia and Alzheimer’s disease in older adults. Alzheimers Dement. 2017; 13 (11):1207–1216. doi: 10.1016/j.jalz.2017.03.003Feart C., Helmer C., Merle B., Herrmann F.R., Annweiler C., Dartigues J.F., Delcourt C., Samieri C. Associations of lower vitamin D concentrations with cognitive decline and long-term risk of dementia and Alzheimer’s disease in older adults. Alzheimers Dement. 2017; 13 (11):1207–1216. doi: 10.1016/j.jalz.2017.03.003Licher S., de Bruijn R., Wolters F.J., Zillikens M.C., Ikram M.A., Ikram M.K. Vitamin D and the risk of dementia: the Rotterdam study. J. Alzheimer Dis. 2017; 60 (3): 989–997. doi: 10.3233/JAD-170407Licher S., de Bruijn R., Wolters F.J., Zillikens M.C., Ikram M.A., Ikram M.K. Vitamin D and the risk of dementia: the Rotterdam study. J. Alzheimer Dis. 2017; 60 (3): 989–997. doi: 10.3233/JAD-170407Olsson E., Byberg L., Karlström B., Cederholm T., Melhus H., Sjögren P., Kilander L. Vitamin D is not associated with incident dementia or cognitive impairment: an 18-y follow-up study in community-living old men. Am. J. Clin. Nutr. 2017; 105 (4): 936– 943. doi: 10.3945/ajcn.116.141531Olsson E., Byberg L., Karlström B., Cederholm T., Melhus H., Sjögren P., Kilander L. Vitamin D is not associated with incident dementia or cognitive impairment: an 18-y follow-up study in community-living old men. Am. J. Clin. Nutr. 2017; 105 (4): 936– 943. doi: 10.3945/ajcn.116.141531Karakis I., Pase M.P., Beiser A., Booth S.L., Jacques P.F., Rogers G., DeCarli C., Vasan R.S., Wang T.J., Himali J.J., Annweiler C., Seshadri S. Association of serum Vitamin D with the risk of incident dementia and subclinical indices of brain aging: the Framingham heart study. J. Alzheimer Dis. 2016; 51 (2): 451–461. doi: 10.3233/JAD-150991Karakis I., Pase M.P., Beiser A., Booth S.L., Jacques P.F., Rogers G., DeCarli C., Vasan R.S., Wang T.J., Himali J.J., Annweiler C., Seshadri S. Association of serum Vitamin D with the risk of incident dementia and subclinical indices of brain aging: the Framingham heart study. J. Alzheimer Dis. 2016; 51 (2): 451–461. doi: 10.3233/JAD-150991Przybelski R., Agrawal S., Krueger D., Engelke J.A., Walbrun F., Binkley N. Rapid correction of low vitamin D status in nursing home residents. Osteoporos Int. 2008; 19 (11): 1621–1628. doi: 10.1007/s00198-008-0619-xPrzybelski R., Agrawal S., Krueger D., Engelke J.A., Walbrun F., Binkley N. Rapid correction of low vitamin D status in nursing home residents. Osteoporos Int. 2008; 19 (11): 1621–1628. doi: 10.1007/s00198-008-0619-xRossom R.C., Espeland M.A., Manson J.E., Dysken M.W., Johnson K.C., Lane D.S., LeBlanc E.S., Lederle F.A., Masaki K.H., Margolis K.L. Calcium and vitamin D supplementation and cognitive impairment in the women’s health initiative. J. Am. Geriatr. Soc. 2012; 60 (12): 2197–2205. doi: 10.1111/jgs.12032Rossom R.C., Espeland M.A., Manson J.E., Dysken M.W., Johnson K.C., Lane D.S., LeBlanc E.S., Lederle F.A., Masaki K.H., Margolis K.L. Calcium and vitamin D supplementation and cognitive impairment in the women’s health initiative. J. Am. Geriatr. Soc. 2012; 60 (12): 2197–2205. doi: 10.1111/jgs.12032Moran C., Palumbo A., Bramham J., Moran A., Rooney B., de Vito G., Egan B. Effects of a six-month multi-ingredient nutrition nupplement intervention of omega-3 polyunsaturated fatty acids, vitamin D, resveratrol, and whey protein on cognitive function in older adults: a randomised, double-blind, controlled trial. J. Prev. Alzheimers Dis. 2018; 5 (3): 175–183. doi: 10.14283/jpad.2018.11Moran C., Palumbo A., Bramham J., Moran A., Rooney B., de Vito G., Egan B. Effects of a six-month multi-ingredient nutrition nupplement intervention of omega-3 polyunsaturated fatty acids, vitamin D, resveratrol, and whey protein on cognitive function in older adults: a randomised, double-blind, controlled trial. J. Prev. Alzheimers Dis. 2018; 5 (3): 175–183. doi: 10.14283/jpad.2018.11Munoz-Fernandez S.S., Ivanauskas T., Lima Ribeiero S.M. Nutritional strategies in the management of Alzheimer Disease: systematic review with network meta-analysis. J. Am. Med. Dir. Assoc. 2017; 18 (10): 897 e13–897.e30. doi: 10.1016/j.jamda.2017.06.015Munoz-Fernandez S.S., Ivanauskas T., Lima Ribeiero S.M. Nutritional strategies in the management of Alzheimer Disease: systematic review with network meta-analysis. J. Am. Med. Dir. Assoc. 2017; 18 (10): 897 e13–897.e30. doi: 10.1016/j.jamda.2017.06.015Annweiler C., Hermann F.R., Fantino B., Brugg B., Beauchet O. Effectiveness of the combination of memantine plus vitamin D on cognition in patients with Alzheimer disease: a pre-post pilot study. Cogn. Behav Neurol. 2012; 25 (3): 121–127. doi: 10.1097/WNN.0b013e31826df647Annweiler C., Hermann F.R., Fantino B., Brugg B., Beauchet O. Effectiveness of the combination of memantine plus vitamin D on cognition in patients with Alzheimer disease: a pre-post pilot study. Cogn. Behav Neurol. 2012; 25 (3): 121–127. doi: 10.1097/WNN.0b013e31826df647Bonnet A.M., Houeto J.L. Pathophysiology of Parkinson’s disease. Biomed. Pharmacother. 1999; 53 (3):117–121. doi: 10.1016/S0753-3322(99)80076-6Bonnet A.M., Houeto J.L. Pathophysiology of Parkinson’s disease. Biomed. Pharmacother. 1999; 53 (3):117–121. doi: 10.1016/S0753-3322(99)80076-6Marsili L., Rizzo G., Colosimo C. Diagnostic criteria for Parkinson’s disease: from James Parkinson to the concept of prodromal disease. Front. Neurol. 2018; 9: 156. doi: 10.3389/fneur.2018.00156 doi: 10.3389/fneur.2018.00156Marsili L., Rizzo G., Colosimo C. Diagnostic criteria for Parkinson’s disease: from James Parkinson to the concept of prodromal disease. Front. Neurol. 2018; 9: 156. doi: 10.3389/fneur.2018.00156 doi: 10.3389/fneur.2018.00156Annweiler C., Schott A.M., Berrut G., Chauviré V., Le Gall D., Inzitari M., Beauchet O. Vitamin D and ageing: neurological issues. Neuropsychobiology. 2010; 62 (3): 139–150. doi: 10.1159/000318570Annweiler C., Schott A.M., Berrut G., Chauviré V., Le Gall D., Inzitari M., Beauchet O. Vitamin D and ageing: neurological issues. Neuropsychobiology. 2010; 62 (3): 139–150. doi: 10.1159/000318570Evatt M.L., Delong M.R., Khazai N., Rosen A., Triche S., Tangpricha V. Prevalence of vitamin d insufficiency in patients with Parkinson disease and Alzheimer disease. Arch. Neurol. 2008; 65 (10): 1348– 1352. doi: 10.1001/archneur.65.10.1348Evatt M.L., Delong M.R., Khazai N., Rosen A., Triche S., Tangpricha V. Prevalence of vitamin d insufficiency in patients with Parkinson disease and Alzheimer disease. Arch. Neurol. 2008; 65 (10): 1348– 1352. doi: 10.1001/archneur.65.10.1348Sato Y., Kikuyama M., Ozumi K. High prevalence of vitamin D deficiency and reduced bone mass in Parkinson disease. Neurology. 1997; 49 (5): 1273– 1278. doi: 10.1212/wnl.49.5.1273Sato Y., Kikuyama M., Ozumi K. High prevalence of vitamin D deficiency and reduced bone mass in Parkinson disease. Neurology. 1997; 49 (5): 1273– 1278. doi: 10.1212/wnl.49.5.1273Knekt P., Kilkkinen A., Rissanen H., Marniemi J., Sääksjärvi K., Heliövaara M. Serum vitamin D and the risk of Parkinson disease. Arch. Neurol. 2010; 67 (7): 808–811. doi: 10.1001/archneurol.2010.120Knekt P., Kilkkinen A., Rissanen H., Marniemi J., Sääksjärvi K., Heliövaara M. Serum vitamin D and the risk of Parkinson disease. Arch. Neurol. 2010; 67 (7): 808–811. doi: 10.1001/archneurol.2010.120Ding H., Dhima K., Lockhart K.C., Locascio J.J., Hoesing A.N., Duong K., Trisini-Lipsanopoulos A., Hayes M.T., Sohur U.S., Wills A.M., Mollenhauer B., Flaherty A.W., Hung A.Y., Mejia N., Khurana V., Gomperts S.N., Selkoe D.J., Schwarzschild M.A., Schlossmacher M.G., Hyman B.T., Sudarsky L.R., Growdon J.H., Scherzer C.R. Unrecognized vitamin D3 deficiency is common in Parkinson disease: Harvard biomarker study. Neurology. 2013. 81 (17): 1531–1537. doi: 10.1212/WNL.0b013e3182a95818Ding H., Dhima K., Lockhart K.C., Locascio J.J., Hoesing A.N., Duong K., Trisini-Lipsanopoulos A., Hayes M.T., Sohur U.S., Wills A.M., Mollenhauer B., Flaherty A.W., Hung A.Y., Mejia N., Khurana V., Gomperts S.N., Selkoe D.J., Schwarzschild M.A., Schlossmacher M.G., Hyman B.T., Sudarsky L.R., Growdon J.H., Scherzer C.R. Unrecognized vitamin D3 deficiency is common in Parkinson disease: Harvard biomarker study. Neurology. 2013. 81 (17): 1531–1537. doi: 10.1212/WNL.0b013e3182a95818Orme R.P., Bhangal M.S., Fricker R.A. Calcitriol imparts neuroprotection in vitro to midbrain dopaminergic neurons by upregulating GDNF expression. PLoS One. 2013; 8940: e62040. doi: 10.1371/journal. pone.0062040Orme R.P., Bhangal M.S., Fricker R.A. Calcitriol imparts neuroprotection in vitro to midbrain dopaminergic neurons by upregulating GDNF expression. PLoS One. 2013; 8940: e62040. doi: 10.1371/journal. pone.0062040Cass W.A., Smith M.P., Peters L.E. Calcitriol protects against the dopamine- and serotonin-depleting effects of neurotoxic doses of methamphetamine. Ann. NY Acad. Sci. 2014; 1074: 261–271. doi: 10.1196/annals.1369.023Cass W.A., Smith M.P., Peters L.E. Calcitriol protects against the dopamine- and serotonin-depleting effects of neurotoxic doses of methamphetamine. Ann. NY Acad. Sci. 2014; 1074: 261–271. doi: 10.1196/annals.1369.023Orme R.P., Middleditch C., Waite L., Fricker R.A. The role of vitamin D 3 in the development and neuroprotection of midbrain dopamine neurons. Vitam. Horm. 2016; 100: 273–297. doi: 10.1016/bs.vh.2015.10.007Orme R.P., Middleditch C., Waite L., Fricker R.A. The role of vitamin D 3 in the development and neuroprotection of midbrain dopamine neurons. Vitam. Horm. 2016; 100: 273–297. doi: 10.1016/bs.vh.2015.10.007Suzuki M., Yoshioka M., Hashimoto M., Murakami M., Noya M., Takahashi D., Urashima M. Randomized, double-blind, placebo-controlled trial of vitamin D supplementation in Parkinson disease. Am. J. Clin. Nutr. 2013; 97 (5): 1004–1013. doi: 10.3945/ajcn.112.051664Suzuki M., Yoshioka M., Hashimoto M., Murakami M., Noya M., Takahashi D., Urashima M. Randomized, double-blind, placebo-controlled trial of vitamin D supplementation in Parkinson disease. Am. J. Clin. Nutr. 2013; 97 (5): 1004–1013. doi: 10.3945/ajcn.112.051664Cui X., Pelekanos M., Liu P.Y., Burne T.H., McGrath J.J., Eyles D.W. The Vitamin D receptor in dopamine neurons; its presence in human substantia nigra and its ontogenesis in rat midbrain. Neuroscience. 2013; 236: 77–87. doi: 10.1016/j.neuroscience.2013.01.035Cui X., Pelekanos M., Liu P.Y., Burne T.H., McGrath J.J., Eyles D.W. The Vitamin D receptor in dopamine neurons; its presence in human substantia nigra and its ontogenesis in rat midbrain. Neuroscience. 2013; 236: 77–87. doi: 10.1016/j.neuroscience.2013.01.035Pugliatti M., Harbo H.F., Holmøy T., Kampman M.T., Myhr K.M., Riise T., Wolfson C. Environmental risk factors in multiple sclerosis. Acta Neurol. Scand. Suppl. 2008; 188: 34–40. doi: 10.1111/j.1600-0404.2008.01029.xPugliatti M., Harbo H.F., Holmøy T., Kampman M.T., Myhr K.M., Riise T., Wolfson C. Environmental risk factors in multiple sclerosis. Acta Neurol. Scand. Suppl. 2008; 188: 34–40. doi: 10.1111/j.1600-0404.2008.01029.xMazdeh M., Seifirad S., Kazemi N., Seifrabie M.A., Dehghan A., Abbasi H. Comparison of vitamin D3 serum levels in new diagnosed patients with multiple sclerosis versus their healthy relatives. Acta Med. Iran. 2013; 51 (5): 289–292.Mazdeh M., Seifirad S., Kazemi N., Seifrabie M.A., Dehghan A., Abbasi H. Comparison of vitamin D3 serum levels in new diagnosed patients with multiple sclerosis versus their healthy relatives. Acta Med. Iran. 2013; 51 (5): 289–292.Ascherio A., Munger K.L. Epidemiology of multiple sclerosis: from risk factors to prevention-an update. Semin. Neurol. 2016; 36 (2): 103–114. doi: 10.1055/s-0036-1579693Ascherio A., Munger K.L. Epidemiology of multiple sclerosis: from risk factors to prevention-an update. Semin. Neurol. 2016; 36 (2): 103–114. doi: 10.1055/s-0036-1579693Simpson S.Jr., Taylor B., Blizard L., Ponsonby A.L., Pittas F., Tremlett H., Dwyer T., Gies P., van der Mei I. Higher 25-hydroxyvitamin D is associated with lower relapse risk in multiple sclerosis. Ann. Neurol. 2010; 68 (2): 193–203. doi: 10.1002/ana.22043Simpson S.Jr., Taylor B., Blizard L., Ponsonby A.L., Pittas F., Tremlett H., Dwyer T., Gies P., van der Mei I. Higher 25-hydroxyvitamin D is associated with lower relapse risk in multiple sclerosis. Ann. Neurol. 2010; 68 (2): 193–203. doi: 10.1002/ana.22043Munger K.L., Levin L.I., Hollis B.W., Howard N.S., Ascherio A. Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis. JAMA. 2006; 296 (23): 2832–2838. doi: 10.1001/jama.296.23.2832Munger K.L., Levin L.I., Hollis B.W., Howard N.S., Ascherio A. Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis. JAMA. 2006; 296 (23): 2832–2838. doi: 10.1001/jama.296.23.2832Cortese M., Riise T., Bjørnevik K., Holmøy T., Kampman M.T., Magalhaes S., Pugliatti M., Wolfson C., Myhr K.M. Timing of use of cod liver oil, a vitamin D source, and multiple sclerosis risk: the EnvIMS study. Mult. Scler. 2015; 21 (14): 1856–1864. doi: 10.1177/1352458515578770Cortese M., Riise T., Bjørnevik K., Holmøy T., Kampman M.T., Magalhaes S., Pugliatti M., Wolfson C., Myhr K.M. Timing of use of cod liver oil, a vitamin D source, and multiple sclerosis risk: the EnvIMS study. Mult. Scler. 2015; 21 (14): 1856–1864. doi: 10.1177/1352458515578770Pozuelo-Moyano B., Benito-León J., Mitchell A.J., Hernández-Gallego J. A systematic review of randomized, double-blind, placebo-controlled trials examining the clinical efficacy of vitamin D in multiple sclerosis. Neuroepidemiology. 2013; 40 (3): 147–153. doi: 10.1159/000345122Pozuelo-Moyano B., Benito-León J., Mitchell A.J., Hernández-Gallego J. A systematic review of randomized, double-blind, placebo-controlled trials examining the clinical efficacy of vitamin D in multiple sclerosis. Neuroepidemiology. 2013; 40 (3): 147–153. doi: 10.1159/000345122The International Multiple Sclerosis Genetics Consortium, The Wellcome Trust Case Control Consortium 2. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature. 2011; 476 (7359): 214–219. doi: 10.1038/nature10251The International Multiple Sclerosis Genetics Consortium, The Wellcome Trust Case Control Consortium 2. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature. 2011; 476 (7359): 214–219. doi: 10.1038/nature10251Jia F., Shan L., Wang B., Li H., Miao C., Xu Z., Lin C.P., Saad K. Bench to bedside review: possible role of vitamin D in autism spectrum disorder. Psychiatry Res. 2018; 260: 360–365. doi: 10.1016/j.psychres.2017.12.005Jia F., Shan L., Wang B., Li H., Miao C., Xu Z., Lin C.P., Saad K. Bench to bedside review: possible role of vitamin D in autism spectrum disorder. Psychiatry Res. 2018; 260: 360–365. doi: 10.1016/j.psychres.2017.12.005Meguid N.A., Hashish A.F., Anwar M., Sidhom G. Reduced serum levels of 25-hydroxy and 1,25-dihydroxy vitamin D in Egyptian children with autism. J. Altern. Complement Med. 2010; 16 (6): 641– 645. doi: 10.1089/acm.2009.0349Meguid N.A., Hashish A.F., Anwar M., Sidhom G. Reduced serum levels of 25-hydroxy and 1,25-dihydroxy vitamin D in Egyptian children with autism. J. Altern. Complement Med. 2010; 16 (6): 641– 645. doi: 10.1089/acm.2009.0349Mostafa G.A., Al-Ayadhi L.Y. Reduced serum concentrations of 25-hydroxy vitamin D in children with autism: relation to autoimmunity. J. Neuroinflammation. 2012; 9: 201. doi: 10.1186/1742-2094-9-201Mostafa G.A., Al-Ayadhi L.Y. Reduced serum concentrations of 25-hydroxy vitamin D in children with autism: relation to autoimmunity. J. Neuroinflammation. 2012; 9: 201. doi: 10.1186/1742-2094-9-201Neumeyer A.M., Gates A., Ferrone C., Lee H., Misra M. Bone density in peripubertal boys with autism spectrum disorders. J. Autism Dev. Disord. 2013; 43 (7): 1623–1629. doi: 10.1007/s10803-012-1709-3Neumeyer A.M., Gates A., Ferrone C., Lee H., Misra M. Bone density in peripubertal boys with autism spectrum disorders. J. Autism Dev. Disord. 2013; 43 (7): 1623–1629. doi: 10.1007/s10803-012-1709-3Gong Z.L., Luo C.M., Wang L., Shen L., Wei F., Tong R.J., Liu Y. Serum 25-hydroxyvitamin D levels in Chinese children with autism spectrum disorders. Neuroreport. 2014; 25 (1): 23–27. doi: 10.1097/WNR.0000000000000034Gong Z.L., Luo C.M., Wang L., Shen L., Wei F., Tong R.J., Liu Y. Serum 25-hydroxyvitamin D levels in Chinese children with autism spectrum disorders. Neuroreport. 2014; 25 (1): 23–27. doi: 10.1097/WNR.0000000000000034Bener A., Khattab A.O., Al-Dabbagh M.M. Is high prevalence of Vitamin D deficiency evidence for autism disorder? In a highly endogamous population. J. Pediatr. Neurosci. 2014; 9 (3): 227–233. doi: 10.4103/1817-1745.147574Bener A., Khattab A.O., Al-Dabbagh M.M. Is high prevalence of Vitamin D deficiency evidence for autism disorder? In a highly endogamous population. J. Pediatr. Neurosci. 2014; 9 (3): 227–233. doi: 10.4103/1817-1745.147574Du L., Shan L., Wang B., Feng J.Y., Xu Z.D., Jia F.Y. Serum levels of 25-hydroxyvitamin D in children with autism spectrum disorders. Zhongguo Dang Dai Er Ke Za Zhi. 2015; 17 (1): 68–71. doi: 10.1186/s13052-018-0587-5Du L., Shan L., Wang B., Feng J.Y., Xu Z.D., Jia F.Y. Serum levels of 25-hydroxyvitamin D in children with autism spectrum disorders. Zhongguo Dang Dai Er Ke Za Zhi. 2015; 17 (1): 68–71. doi: 10.1186/s13052-018-0587-5Fernell E., Barnevik-Olsson M., Bågenholm G., Gillberg C., Gustafsson S., Sääf M. Serum levels of 25-hydroxyvitamin D in mothers of Swedish and of Somali origin who have children with and without autism. Acta Paediatr. 2010; 99 (5): 743–747. doi: 10.1111/j.1651-2227.2010.01755.xFernell E., Barnevik-Olsson M., Bågenholm G., Gillberg C., Gustafsson S., Sääf M. Serum levels of 25-hydroxyvitamin D in mothers of Swedish and of Somali origin who have children with and without autism. Acta Paediatr. 2010; 99 (5): 743–747. doi: 10.1111/j.1651-2227.2010.01755.xAdams J.B., Audhya T., McDonoughMeans S., Rubin A.R., Quig D., Geis E., Gehn E., Loresto M., Mitchel J., Atwood S., Barnhouse S., Lee W. Nutritional and metabolic status of children with autism vs neurotypical children, and the association with autism severity. Nutr. Metab. (Lond.). 2011; 8 (1): 34. doi: 10.1186/1743-7075-8-34Adams J.B., Audhya T., McDonoughMeans S., Rubin A.R., Quig D., Geis E., Gehn E., Loresto M., Mitchel J., Atwood S., Barnhouse S., Lee W. Nutritional and metabolic status of children with autism vs neurotypical children, and the association with autism severity. Nutr. Metab. (Lond.). 2011; 8 (1): 34. doi: 10.1186/1743-7075-8-34Ugur C., Gurkan C.K. Serum vitamin D and folate levels in children with autism spectrum disorders. Autism Spectr. Disord. 2014; 8 (12): 1641–1647. doi: 10.1016/j.rasd.2014.09.002Ugur C., Gurkan C.K. Serum vitamin D and folate levels in children with autism spectrum disorders. Autism Spectr. Disord. 2014; 8 (12): 1641–1647. doi: 10.1016/j.rasd.2014.09.002Wang T., Shan L., Du L., Feng J., Xu Z., Staal W.G., Jia F. Serum concentration of 25-hydroxyvitamin D in autism spectrum disorder: a systematic review and meta-analysis. Eur. Child Adolesc. Psychiatry. 2016; 25 (4): 341–350. doi: 10.1007/s00787-015-0786-1Wang T., Shan L., Du L., Feng J., Xu Z., Staal W.G., Jia F. Serum concentration of 25-hydroxyvitamin D in autism spectrum disorder: a systematic review and meta-analysis. Eur. Child Adolesc. Psychiatry. 2016; 25 (4): 341–350. doi: 10.1007/s00787-015-0786-1Saad K., Abdel-Rahman A.A., Elserogy Y.M., Al-Atram A.A., El-Houfey A.A., Othman H.A., Bjørklund G., Jia F., Urbina M.A., Abo-Elela M.G.M., Ahmad F.A., Abd El-Baseer K.A., Ahmed A.E., AbdelSalam A.M. Randomized controlled trial of vitamin D supplementation in children with autism spectrum disorder. J. Child Psychol. Psychiatry. 2018; 59 (1): 20–29. doi: 10.1111/jcpp.12652Saad K., Abdel-Rahman A.A., Elserogy Y.M., Al-Atram A.A., El-Houfey A.A., Othman H.A., Bjørklund G., Jia F., Urbina M.A., Abo-Elela M.G.M., Ahmad F.A., Abd El-Baseer K.A., Ahmed A.E., AbdelSalam A.M. Randomized controlled trial of vitamin D supplementation in children with autism spectrum disorder. J. Child Psychol. Psychiatry. 2018; 59 (1): 20–29. doi: 10.1111/jcpp.12652Kokovska E., Fernell E., Billstedt E., Minnis H., Gillberg C. Vitamin D and autism: clinical review. Res. Dev. Disabil. 2012; 33 (5): 1541–1550. doi: 10.1016/j.ridd.2012.02.015Kokovska E., Fernell E., Billstedt E., Minnis H., Gillberg C. Vitamin D and autism: clinical review. Res. Dev. Disabil. 2012; 33 (5): 1541–1550. doi: 10.1016/j.ridd.2012.02.015Patrick R.P., Ames B.N. Vitamin D hormone regulates serotonin synthesis. Part 1: relevance for autism. FASEB J. 2014; 28 (6): 2398–2413. doi: 10.1096/fj.13-246546Patrick R.P., Ames B.N. Vitamin D hormone regulates serotonin synthesis. Part 1: relevance for autism. FASEB J. 2014; 28 (6): 2398–2413. doi: 10.1096/fj.13-246546Gominak S.C., Stumpf W.S. The world epidemic of sleep disorders is linked to vitamin D deficiency. Med. Hypotheses. 2012; 79 (2): 132–135. doi: 10.1016/j.mehy.2012.03.031Gominak S.C., Stumpf W.S. The world epidemic of sleep disorders is linked to vitamin D deficiency. Med. Hypotheses. 2012; 79 (2): 132–135. doi: 10.1016/j.mehy.2012.03.031Andersen M.L., Tufik S. Vitamin D as an underlying factor in sleep-related issues. J. Clin. Sleep Med. 2012; 8 (6): 699. doi: 10.5664/jcsm.2268Andersen M.L., Tufik S. Vitamin D as an underlying factor in sleep-related issues. J. Clin. Sleep Med. 2012; 8 (6): 699. doi: 10.5664/jcsm.2268Mccarty D.E., Reddy A., Keigley Q., Kim P.Y., Marino A.A. Vitamin D, race, and excessive daytime sleepiness. J. Clin. Sleep Med. 2012; 8: 693–697. doi: 10.5664/jcsm.2266Mccarty D.E., Reddy A., Keigley Q., Kim P.Y., Marino A.A. Vitamin D, race, and excessive daytime sleepiness. J. Clin. Sleep Med. 2012; 8: 693–697. doi: 10.5664/jcsm.2266Shahi M.M., Hosseini S.A., Helli B., Haghighyzade M.H., Abolfathi M. The effect of vitamin D supplement on quality of sleep in adult people with sleep disorders. Tehran Univ. Med. J. 2017; 75: 443–448.Shahi M.M., Hosseini S.A., Helli B., Haghighyzade M.H., Abolfathi M. The effect of vitamin D supplement on quality of sleep in adult people with sleep disorders. Tehran Univ. Med. J. 2017; 75: 443–448.Huang W., Shah S., Long Q., Crankshaw A.K., Tangpricha V. Improvement of pain, sleep, and quality of life in chronic pain patients with vitamin d supplementation. Clin. J. Pain. 2013; 29: 341–347. doi: 10.1097/AJP.0b013e318255655dHuang W., Shah S., Long Q., Crankshaw A.K., Tangpricha V. Improvement of pain, sleep, and quality of life in chronic pain patients with vitamin d supplementation. Clin. J. Pain. 2013; 29: 341–347. doi: 10.1097/AJP.0b013e318255655dGao Q., Kou T., Zhuang B., Ren Y., Dong X., Wang Q. Association between Vitamin D deficiency and sleep disorders: a systematic review and metaanalysis. Nutrients. 2018; 10 (10): E1395. doi: 10.3390/nu10101395Gao Q., Kou T., Zhuang B., Ren Y., Dong X., Wang Q. Association between Vitamin D deficiency and sleep disorders: a systematic review and metaanalysis. Nutrients. 2018; 10 (10): E1395. doi: 10.3390/nu10101395Eyles D., Trzaskowski M., Vinkhuyzen A., Mattheisen M., Meier S., Gooch H., Anggono V., Cui X., Tan M.C., Burne T.H.J., Jang S.E., Kvaskoff D., Hougaard D.M., Nørgaard-Pedersen B., Cohen A., Agerbo E., Pedersen C.B., Børglum A.D., Mors O., Sah P., Wray N.R., Mortensen P.B., McGrath J.J. The association between neonatal vitamin D status and risk of schizophrenia. Sci. Rep. 2018; 8 (1): 17692. doi: 10.1038/s41598-018-35418-zEyles D., Trzaskowski M., Vinkhuyzen A., Mattheisen M., Meier S., Gooch H., Anggono V., Cui X., Tan M.C., Burne T.H.J., Jang S.E., Kvaskoff D., Hougaard D.M., Nørgaard-Pedersen B., Cohen A., Agerbo E., Pedersen C.B., Børglum A.D., Mors O., Sah P., Wray N.R., Mortensen P.B., McGrath J.J. The association between neonatal vitamin D status and risk of schizophrenia. Sci. Rep. 2018; 8 (1): 17692. doi: 10.1038/s41598-018-35418-zGraham K.A., Keefe R.S., Lieberman J.A., Calikoglu A.S., Lansing K.M., Perkins D.O. Relationship of low vitamin D status with positive, negative and cognitive symptom domains in people with firstepisode schizophrenia. Early Interv. Psychiatry. 2015; 9 (5): 397–405. doi: 10.1111/eip.12122Graham K.A., Keefe R.S., Lieberman J.A., Calikoglu A.S., Lansing K.M., Perkins D.O. Relationship of low vitamin D status with positive, negative and cognitive symptom domains in people with firstepisode schizophrenia. Early Interv. Psychiatry. 2015; 9 (5): 397–405. doi: 10.1111/eip.12122Valipour G., Saneei P., Esmaillzadeh A. Serum vitamin D levels in relation to schizophrenia: a systematic review and meta-analysis of observational studies. J. Clin. Endocrinol. Metab. 2014; 99 (10): 3863–3872. doi: 10.1210/jc.2014-1887Valipour G., Saneei P., Esmaillzadeh A. Serum vitamin D levels in relation to schizophrenia: a systematic review and meta-analysis of observational studies. J. Clin. Endocrinol. Metab. 2014; 99 (10): 3863–3872. doi: 10.1210/jc.2014-1887

The authors declare that there are no conflicts of interest present.