sibmedСибирский научный медицинский журналСибирский научный медицинский журнал2410-25122410-2520ИЦиГ СО РАН10.15372/SSMJ20200501sibmed-483Research ArticleОБЗОРЫREVIEWSГенетика синтропии «атопический марш»Genetics of «atopic march» syntropyhttps://orcid.org/0000-0002-1103-3073БрагинаЕ. Ю.BraginaE. Yu.

Елена Юрьевна Брагина, к.б.н.

634050, г. Томск, наб. реки Ушайки, 10

Elena Yu. Bragina, candidate of biological sciences

634050, Tomsk, Ushaika river embankment, 10

elena.bragina72@gmail.comhttps://orcid.org/0000-0002-1439-6259ФрейдинМ. Б.FreidinM. B.

Максим Борисович Фрейдин, д.б.н.

634050, г. Томск, наб. реки Ушайки, 10

Maxim B. Freidin, doctor of biological sciences

634050, Tomsk, Ushaika river embankment, 10

mfreidin@medgenetics.ruhttps://orcid.org/0000-0002-2113-4556ПузырёвВ. П.PuzyrevV. P.

Валерий Павлович Пузырёв, д.м.н., проф., академик РАН

634050, г. Томск, наб. реки Ушайки, 10

634050, г. Томск, Московский тракт, 2

Valery P. Puzyrev, doctor of medical sciences, professor, academician of RAS

634050, Tomsk, Ushaika river embankment, 10

634050, Tomsk, Moskovsky path., 2

p.valery@medgenetics.ruНИИ медицинской генетики Томского национального исследовательского медицинского центра РАНРоссияResearch Institute of Medical Genetics, Tomsk NRMC of RASRussian FederationНИИ медицинской генетики Томского национального исследовательского медицинского центра РАН; Сибирский государственный медицинский университет Минздрава РоссииРоссияResearch Institute of Medical Genetics, Tomsk NRMC of RAS; Siberian State Medical University of Minzdrav of RussiaRussian Federation202019112020405417Copyright © Брагина Е.Ю., Фрейдин М.Б., Пузырёв В.П., 20202020Брагина Е.Ю., Фрейдин М.Б., Пузырёв В.П.Bragina E.Y., Freidin M.B., Puzyrev V.P.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://sibmed.elpub.ru/jour/article/view/483

Исследования феномена сочетания одновременно нескольких болезней у отдельного индивидуума, актуализированные во второй половине XIX в., спустя 150 лет активно анализируются с использованием генетических подходов. В статье представлен обзор результатов таких исследований в отношении аллергических заболеваний, в частности особого их варианта, так называемого «атопического марша», последовательного развития экземы, аллергического ринита и астмы (синтропия «атопический марш»). Обобщены результаты генетических и эпидемиологических исследований, проведен анализ работ поиска полногеномных ассоциаций, рассмотрена роль мутаций в гене филаггрина (FLG) в развитии данной синтропии.

The study of the phenomenon of a combination of several diseases at the same time in an individual, actualized in the second half of the 19th century, is being actively analyzed 150 years later using genetic approaches. We present an overview of the results of such studies in relation to allergic diseases, in particular, a special variant, the so-called «atopic march», the sequential development of eczema, allergic rhinitis and asthma («atopic march» syntropy). The data of genetic and epidemiological studies were summarized, the analysis of genome-wide associative studies was carried out, and the role of mutations in the filaggrin gene (FLG) in the development of the «atopic march» syntropy was considered.

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The authors declare that there are no conflicts of interest present.