sibmedСибирский научный медицинский журналСибирский научный медицинский журнал2410-25122410-2520ИЦиГ СО РАН10.15372/SSMJ20200201sibmed-364Research ArticleОБЗОРЫREVIEWSТромбоцитарные микровезикулы и их роль в обеспечении гемостатического потенциала (обзор литературы)Platelet microvesicles and their role in providing hemostatic capacity (literature review)https://orcid.org/0000-0002-8413-5484МомотА. П.MomotA. P.

Андрей Павлович Момот, д.м.н., проф.

656045, г. Барнаул, ул. Ляпидевского, 1, корп. 2

Andrey P. Momot, doctor of medical sciences, professor

656045, Barnaul, Lyapidevskogo str., 1, bldg. 2

xyzan@yandex.ruЦаригородцеваН. О.TsarigorodtsevaN. O.

Наталья Олеговна Царигородцева

656038, г. Барнаул, просп. Ленина, 40

Natalia O. Tsarigorodtseva

656038, Barnaul, Lenina av., 40

misssherlockian@gmail.comФёдоровД. В.FedorovD. V.

Дмитрий Владимирович Фёдоров, д.м.н., проф.

656038, г. Барнаул, просп. Ленина, 40

Dmitry V. Fedorov, doctor of medical sciences, professor

656038, Barnaul, Lenina av., 40

dima.fedorovdv@yandex.ruБишевскийК. М.BishevskiK. M.

Константин Михайлович Бишевский, к.м.н.

656038, г. Барнаул, просп. Ленина, 40

Konstantin M. Bishevski, candidate of medical sciences

656038, Barnaul, Lenina av., 40

kombish@yandex.ruВостриковаН. В.VostrikovaN. V.

Наталья Владимировна Вострикова, к.м.н.

656038, г. Барнаул, просп. Ленина, 40

Natalia V. Vostrikova, candidate of medical sciences

656038, Barnaul, Lenina av., 40

benzobak10@yandex.ruКлимоваЕ. Е.KlimovaE. E.

Елена Евгеньевна Климова, к.м.н.

656038, г. Барнаул, просп. Ленина, 40

Elena E. Klimova, candidate of medical sciences

656038, Barnaul, Lenina av., 40

elenklim@icloud.comНациональный медицинский исследовательский центр гематологии Минздрава России, Алтайский филиалРоссияAltai Branch of National Research Center for Hematology of Minzdrav of RussiaRussian FederationАлтайский государственный медицинский университет Минздрава РоссииРоссияAltai State Medical University of Minzdrav of RussiaRussian Federation202001052020402414Copyright © Момот А.П., Царигородцева Н.О., Фёдоров Д.В., Бишевский К.М., Вострикова Н.В., Климова Е.Е., 20202020Момот А.П., Царигородцева Н.О., Фёдоров Д.В., Бишевский К.М., Вострикова Н.В., Климова Е.Е.Momot A.P., Tsarigorodtseva N.O., Fedorov D.V., Bishevski K.M., Vostrikova N.V., Klimova E.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://sibmed.elpub.ru/jour/article/view/364

В последние годы активно изучается роль микровезикул в передаче сигналов эндокринной системы, в обеспечении межклеточного взаимодействия, в переносе белков и нуклеиновых кислот из одной клетки в другую, в регуляции ангиогенеза, в воспалительных реакциях и в метастазировании опухолей. В данной публикации рассматриваются механизмы их образования, строение и потенциальное значение в качестве биологических маркеров. В числе фундаментальных реакций, связанных с микровезикулами, выделяется их прямое участие в обеспечении гемостатических реакций, направленных на остановку кровотечения при нарушении, в силу разных причин, целостности сосудистой стенки. Важная роль в этом отводится микровезикулам тромбоцитарного происхождения, что подтверждено рядом экспериментальных и клинических исследований. В обзоре оцениваются перспективы клинического применения одного из современных компонентов крови – криопреципитата в качестве источника тромбоцитарных микровезикул.

In recent years the role of microvesicles in endocrine system transmission, in providing cellular connectivity, in transportation of proteins and nucleic acids from one cell to another, in angiogenesis regulation, in inflammatory reactions and in dissemination of tumors is actively studied. This article reviews the mechanisms of microvesicle formation, the structure of microvesicles and their potential value as biomarkers. Among all essential reactions involving microvesicles one thing especially stands out: their direct participation in providing hemostatic reactions for bleeding control in case of a solution of continuity in blood vessels due to different reasons. Platelet microvesicles play an important role in this process, and it has been proved by several experimental and clinical studies. In this review we evaluate prospects for clinical use of one of modern blood components – cryoprecipitate – as the source of platelet microvesicles.

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The authors declare that there are no conflicts of interest present.