sibmedСибирский научный медицинский журналСибирский научный медицинский журнал2410-25122410-2520ИЦиГ СО РАН10.15372/SSMJ20190601sibmed-306Research ArticleОБЗОРЫREVIEWSПотенциальные биохимические маркеры хронического бронхита и бронхиальной астмы. Современное состояние проблемыPotential biochemical markers of chronic bronchitis and bronchial asthma. Current state of the problemhttps://orcid.org/0000-0001-7837-406XКуртуковЕ. А.KurtukovE. A.

Евгений Алексеевич Куртуков

630089, Новосибирск, ул. Бориса Богаткова, 175/1

Yuliya Igorevna Ragino - doctor of medical sciences, professor, corresponding member of RAS.

cawertty@gmail.comhttps://orcid.org/0000-0002-4936-8362РагиноЮ. И.RaginoYu. I.

Юлия Игоревна Рагино  - доктор медицинских наук, профессор, член-корр. РАН.

630089, Новосибирск, ул. Бориса Богаткова, 175/1

Yuliya Igorevna Ragino - doctor of medical sciences, professor, corresponding member of RAS.

630089, Novosibirsk, Boris Bogatkov str., 175/1

ragino@mail.ruНИИ терапии и профилактической медицины - филиал ФИЦ Институт цитологии и генетики, СО РАНРоссияEvgeniy Alekseevich Kurtukov 630089, Novosibirsk, Boris Bogatkov str., 175/1Russian FederationНИИ терапии и профилактической медицины - филиал ФИЦ Институт цитологии и генетики, СО РАНРоссияResearch Institute of Internal and Preventive Medicine -Branch of the Institute of Cytology and Genetics of SB RASRussian Federation201903012020396513Copyright © Куртуков Е.А., Рагино Ю.И., 20202020Куртуков Е.А., Рагино Ю.И.Kurtukov E.A., Ragino Y.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://sibmed.elpub.ru/jour/article/view/306

В литературном обзоре по данным публикаций последних лет систематизируются современные представления о новых биохимических маркерах бронхолегочной патологии, а именно хронической обструктивной болезни легких, хронического бронхита и бронхиальной астмы. Представлена информация о потенциальных биохимических маркерах, ассоциированных с патологией бронхолегочной системы: легочный хемокин, регулируемый активацией (хемокиновый лиганд CCL20), сурфактантные белки А и D, пентраксин-3, дефензины, альфа-1-антитрипсин, белок клеток Клара, интерлейкин-19, резистинподобные молекулы. Для каждой био молекулы описаны ее характеристика, биологические свойства и эффекты, а также результаты экспериментальных и клинических исследований применения при бронхолегочной патологии, ассоциации повышенного уровня в крови с клиническими проявлениями заболеваний. Сделан вывод, что на сегодняшний день существует немалое количество новых потенциальных биомаркеров заболеваний дыхательной системы для ранней и эффективной диагностики, профилактики и терапии заболеваний, однако эффекты некоторых из них либо недостаточно изучены, либо противоречивы и требуют дальнейших исследований, которые активно продолжаются в настоящее время в мире и в России.

The literature review, according to recent publications, systematizes modern ideas about new biochemical markers of bronchopulmonary pathology, namely chronic obstructive pulmonary disease, chronic bronchitis and bronchial asthma. Information on potential biochemical markers associated with pathology of the bronchopulmonary system is presented: pulmonary activation regulated chemokine (chemokine ligand CCL20), surfactant proteins A and D, pentraxin-3, defensins, alpha-1 antitrypsin, Clara cell protein, interleukin-19, resistin-like molecules. For each biomolecule, its characteristic, biological properties and effects are described, as well as the results of experimental and clinical studies of its effects in bronchopulmonary pathology, the association of elevated blood levels of a biomolecule with clinical manifestations of diseases. It is concluded that today there are a considerable number of new potential biomarkers of the respiratory system diseases for early and effective diagnosis, prevention and treatment of diseases, however, the effects of some of them are either insufficiently studied or contradictory and require further research, which is actively ongoing in the whole world and in Russia.

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The authors declare that there are no conflicts of interest present.