sibmedСибирский научный медицинский журналСибирский научный медицинский журнал2410-25122410-2520ИЦиГ СО РАН10.15372/SSMJ20190512sibmed-281Research ArticleКЛИНИЧЕСКАЯ МЕДИЦИНАCLINICAL MEDICINEСВЯЗЬ ПАРАМЕТРОВ ЦЕНТРАЛЬНОГО АОРТАЛЬНОГО ДАВЛЕНИЯ, ОФИСНОГО И СУТОЧНОГО АРТЕРИАЛЬНОГО ДАВЛЕНИЯ С ПОКАЗАТЕЛЯМИ ПОРАЖЕНИЯ ОРГАНОВ-МИШЕНЕЙASSOCIATION BETWEEN PARAMETERS OF CENTRAL AORTIC PRESSURE, OFFICE AND AMBULATORY BLOOD PRESSURE and INDICATORS OF TARGET ORGANS DAMAGEhttps://orcid.org/0000-0003-4342-0315ЦветковаЕ. Е.TsvetkovaE. E.

630089, г. Новосибирск, ул. Бориса Богаткова, 175/1

630089, Novosibirsk, Boris Bogatkov str., 175/1

TL-OXA@mail.ruЛатынцеваЛ. Д.LatyntsevaL. D.

к.м.н.,

630089, г. Новосибирск, ул. Бориса Богаткова, 175/1

candidate of medical sciences

630089, Novosibirsk, Boris Bogatkov str., 175/1

office@iimed.ruhttps://orcid.org/0000-0003-3502-7599КузнецовА. А.KuznetsovA. A.

д.м.н., 

630089, г. Новосибирск, ул. Бориса Богаткова, 175/1

doctor of medical sciences

630089, Novosibirsk, Boris Bogatkov str., 175/1

kuznetsoviimed@gmail.comНИИ терапии и профилактической медицины – филиал ФИЦ Институт цитологии и генетики СО РАНРоссияResearch Institute of Internal and Preventive Medicine – Branch of Federal Research Center Institute of Cytology and Genetics of SB RASRussian Federation201903112019395102109Copyright © Цветкова Е.Е., Латынцева Л.Д., Кузнецов А.А., 20192019Цветкова Е.Е., Латынцева Л.Д., Кузнецов А.А.Tsvetkova E.E., Latyntseva L.D., Kuznetsov A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://sibmed.elpub.ru/jour/article/view/281

Цель исследования – в сравнительном ключе изучить связь параметров центрального аортального давления (ЦАД), офисного и суточного артериального давления с показателями поражения органов-мишеней. Материал и методы. В открытое одномоментное наблюдение типа серии случаев включены 47 последовательных амбулаторных и госпитальных пациентов (22 мужчин и 25 женщин) в возрасте 19–70 лет. Программа исследования включала антропометрию, измерение офисного и суточного артериального давления, аппланационную тонометрию лучевой артерии, запись ЭКГ покоя, эхокардиографию, биохимический анализ крови. При анализе данных использовали методы описательной статистики и общую линейную модель (GLM). Результаты. ЦАД сопоставимо с офисным артериальным давлением и в большей степени, чем суточное артериальное давление, ассоциировано с индикаторами гипертрофии левого желудочка. Систолическое ЦАД было связано со всеми использованными в исследовании электрокардиографическими и эхокардиографическими индексами. Из параметров ЦАД, характеризующих амплификацию и аугментацию пульсовой волны, лишь неаугментированная амплификация систолического давления ассоциировалась с признаками гипертрофии левого желудочка, но показатели амплификации и аугментации пульсовой волны были достаточно тесно связаны с расчетной скоростью клубочковой фильтрации. Заключение. Результаты настоящего исследования обосновывают актуальность использования параметров ЦАД дополнительно к традиционным методам определения артериального давления.

Aim of the study was to investigate in a comparative manner associations between the parameters of central aortic pressure, office and ambulatory blood pressure with indicators of target organ damage. Material and methods. 47 consecutive outpatients and hospital patients (22 men and 25 women) aged 19–70 years were included in the open one-stage follow-up of a series of cases. The study program included anthropometry, measurement of office and ambulatory blood pressure, applanation tonometry of the radial artery, recording of resting ECG, echocardiography, biochemical blood analysis. In analyzing the data, the methods of descriptive statistics and the general linear model (GLM) were used. Results. Central aortic pressure is comparable to office blood pressure and, more than ambulatory blood pressure, was associated with indicators of left ventricular hypertrophy. Systolic central aortic pressure was associated with all electrocardiographic and echocardiographic indices used in the study. Of the central aortic pressure parameters characterizing the amplification and augmentation of the pulse wave, only non-augmented amplification of systolic pressure was associated with signs of left ventricular hypertrophy, but the amplification and augmentation of the pulse wave showed a sufficiently high degree of association with estimated glomerular filtration rate. Conclusion. The results of this study substantiate the relevance of using aortic pressure parameters in addition to traditional methods for determining blood pressure.

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The authors declare that there are no conflicts of interest present.