sibmedСибирский научный медицинский журналСибирский научный медицинский журнал2410-25122410-2520ИЦиГ СО РАН10.18699/SSMJ20260101sibmed-2709Research ArticleОБЗОРЫREVIEWSСовременные возможности бесконтрастной МР-перфузии: от научных исследований до клинической практикиModern capabilities of non-contrast MR perfusion: from research to clinical practicehttps://orcid.org/0000-0003-3082-2315ПоповВ. В.PopovV. V.

Попов Владимир Владимирович

630090, Новосибирск, ул. Институтская, 3а; 630090, Новосибирск, ул. Пирогова, 1

Vladimir V. Popov

630090, Novosibirsk, Institutskaya st., 3a; 630090, Novosibirsk, Pirogova st., 1

popov.v@tomo.nsc.ruhttps://orcid.org/0000-0002-7959-5160СтанкевичЮ. А.StankevichYu. A.

Станкевич Юлия Александровна - к.м.н.

630090, Новосибирск, ул. Институтская, 3а; 630090, Новосибирск, ул. Пирогова, 1

Yuliya A. Stankevich - candidate of medical sciences.

630090, Novosibirsk, Institutskaya st., 3a; 630090, Novosibirsk, Pirogova st., 1

stankevich@tomo.nsc.ruhttps://orcid.org/0000-0002-8880-100XБогомяковаО. Б.BogomyakovaO. B.

Богомякова Ольга Борисовна - к.м.н.

630090, Новосибирск, ул. Институтская, 3а; 630090, Новосибирск, ул. Пирогова, 1

Olga B. Bogomyakova - candidate of medical sciences.

630090, Novosibirsk, Institutskaya st., 3a; 630090, Novosibirsk, Pirogova st., 1

bogom_o@tomo.nsc.ruhttps://orcid.org/0000-0002-1277-4113ТулуповА. А.TulupovA. A.

Тулупов Андрей Александрович - д.м.н., проф., чл.-корр. РАН.

630090, Новосибирск, ул. Институтская, 3а; 630090, Новосибирск, ул. Пирогова, 1

Andrey A. Tulupov - doctor of medical science, professor, corresponding member of RAS.

630090, Novosibirsk, Institutskaya st., 3a; 630090, Novosibirsk, Pirogova st., 1

taa@tomo.nsc.ruИнститут «Международный томографический центр» СО РАН; Новосибирский государственный университетРоссияInternational Tomography Center of SB RAS; Novosibirsk State UniversityRussian Federation202619032026461520Copyright © Попов В.В., Станкевич Ю.А., Богомякова О.Б., Тулупов А.А., 20262026Попов В.В., Станкевич Ю.А., Богомякова О.Б., Тулупов А.А.Popov V.V., Stankevich Y.A., Bogomyakova O.B., Tulupov A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://sibmed.elpub.ru/jour/article/view/2709

Метод бесконтрастной магнитно-резонансной перфузии (arterial spin labeling, ASL) представляет собой современный неинвазивный подход к оценке тканевой перфузии, приобретающий все большее значение в клинической и научной практике. В отличие от традиционных контрастных методов, ASL позволяет количественно оценивать кровоток без введения контрастного вещества, что особенно важно в ряде клинических случаев и при динамическом наблюдении пациентов. Настоящий обзор систематизирует современные данные о возможностях ASL-перфузии, включая основные области клинического применения и перспективные направления развития. Актуальность темы обусловлена растущим интересом к функциональным методам визуализации и необходимостью стандартизации ASL-протоколов для их широкого внедрения в клиническую практику.

Цель исследования – изучить диагностические возможности ASL, проанализировать современные области применения и перспективы развития метода на основе актуальных научных данных.

Материал и методы

Материал и методы. Выполнен ретроспективный обзор рандомизированных клинических и перекрестных исследований с поиском в базах данных PubMed, EMBASE, LILACS, Scopus, eLIBRARY.RU на английском и русском языках за 2015–2025 гг. Ключевые слова, используемые для выбора статей: arterial spin labeling (ASL), pulsed ASL, continuous ASL, pseudocontinuous ASL, diffusion-prepared ASL, artificial intelligence ASL, бесконтрастная МР-перфузия. Результаты. Проанализировано 132 статьи, 81 из которых использована для составления обзора. Представлены разновидности метода ASL, а также возможности его применения, тенденций развития в данной области.

Заключение

Заключение. ASL-перфузия является перспективным неинвазивным методом оценки тканевого кровотока, обладая данными по применению в диагностике различных патологических состояний. Потенциал развития метода связан с методологической и технической оптимизацией, интеграцией искусственного интеллекта на этапе обработки исследования, а также стандартизации протоколов для внедрения в рутинную клиническую практику.

Arterial spin labeling (ASL) perfusion MRI represents a modern non-invasive approach to assessing tissue perfusion that is gaining increasing importance in clinical and research practice. Unlike traditional contrast-enhanced methods, ASL enables quantitative blood flow evaluation without the need for contrast agents, which is particularly valuable in certain clinical scenarios and for longitudinal patient monitoring. This review synthesizes current data on ASL perfusion applications, including key clinical uses and future development prospects. The topic’s relevance stems from growing interest in functional imaging techniques and the need for ASL protocol standardization to facilitate widespread clinical adoption.

Purpose

Purpose: To evaluate the diagnostic capabilities of ASL perfusion MRI by analyzing current applications and future development trends based on contemporary scientific evidence.

Material and methods

Material and methods. A retrospective review of randomized clinical trials and cross-sectional studies was performed from PubMed, EMBASE, LILACS, Scopus, and eLibrary databases (2015–2025) using search terms: «arterial spin labeling,» «pulsed ASL,» «continuous ASL,» «pseudo-continuous ASL,» «diffusion-prepared ASL,» «artificial intelligence ASL,» and their Russian equivalents.

Results

Results. From 132 screened publications, 81 were selected for analysis. The review examined ASL technique variations, clinical applications, and emerging trends in the field. Conclusions. ASL perfusion is a promising non-invasive method for tissue blood flow assessment with demonstrated diagnostic utility across multiple pathologies. Future development potential lies in methodological optimization, artificial intelligence integration for data processing, and protocol standardization for routine clinical implementation.

PASLCASLpCASLvs-ASLdp-pCASLискусственный интеллектPASLCASLpCASLVS-ASLdp-ASLartificial intelligenceАвторы благодарят Министерство науки и высшего образования РФ за доступ к МРТ-оборудованию при выполнении исследования. Раздел, посвященный анализу возможностей ASL в изучении патогенеза инсульта, подготовлен в рамках Государственного задания 1023110800234-5-3.2.25;3.1.4;3.2.12. Раздел, посвященный описанию возможностей МРТ для оценки очагов рассеянного склероза, поддержан грантом Российского научного фонда, проект № 23-15-00377The authors thank the Ministry of Science and Higher Education of the Russian Federation for access to MRI equipment during the study. The section devoted to the analysis of ASL capabilities in the study of stroke pathogenesis was prepared within the framework of state assignment 1023110800234-5-3.2.25;3.1.4;3.2.12. 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The authors declare that there are no conflicts of interest present.