sibmedСибирский научный медицинский журналСибирский научный медицинский журнал2410-25122410-2520ИЦиГ СО РАН10.15372/SSMJ20190502sibmed-270Research ArticleОБЗОРЫREVIEWSСОЛИ ЛИТИЯ В ЭКСПЕРИМЕНТАЛЬНОЙ ОНКОЛОГИИ (ОБЗОР ЛИТЕРАТУРЫ)LITHIUM SALTS IN EXPERIMENTAL ONCOLOGY (REVIEW)https://orcid.org/0000-0002-2812-2574ТаскаеваЮ. С.TaskaevaIu. S.

630060, г. Новосибирск, ул. Тимакова, 2

630090, г. Новосибирск, ул. Пирогова, 1

630060, Novosibirsk, Timakov str., 2

630090, Novosibirsk, Pirogov str., 1

inabrite@yandex.ruhttps://orcid.org/0000-0002-4507-093XБгатоваН. П.BgatovaN. P.

д.б.н., проф., 

630060, г. Новосибирск, ул. Тимакова, 2

doctor of biological sciences, professor,

630060, Novosibirsk, Timakov str., 2

 

n_bgatova@ngs.ruНИИ клинической и экспериментальной лимфологии – филиал ФИЦ Институт цитологии и генетики СО РАН, Новосибирский государственный университетРоссияResearch Institute of Clinical and Experimental Lymphology – Branch of Federal Research Center Institute of Cytology and Genetics of SB RAS, Novosibirsk State UniversityRussian FederationНИИ клинической и экспериментальной лимфологии – филиал ФИЦ Институт цитологии и генетики СО РАНРоссияResearch Institute of Clinical and Experimental Lymphology – Branch of Federal Research Center Institute of Cytology and Genetics of SB RASRussian Federation2019011120193951218Copyright © Таскаева Ю.С., Бгатова Н.П., 20192019Таскаева Ю.С., Бгатова Н.П.Taskaeva I.S., Bgatova N.P.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://sibmed.elpub.ru/jour/article/view/270

В последние годы соли лития рассматривают как потенциальные соединения для таргетной терапии, способные замедлить рост опухоли. Имеется большое количество публикаций, свидетельствующих об эффектах лития на сигнальные пути, используемые опухолевыми клетками для роста и развития, и продемонстрировавших возможность его применения в качестве противоопухолевого агента в экспериментальной онкологии. Перспективность применения солей лития для разработки противоопухолевых препаратов связана с тем, что Li имеет две основные внутриклеточные мишени: киназу гликогенсинтазы 3β (glycogen synthase kinase 3β, GSK-3β) и инозитолмонофосфатазу (inositol monophosphatase, IMPase), ингибирование которых может индуцировать гибель раковой клетки путем апоптоза или аутофагии. Показано, что литий вызывает остановку пролиферации опухолевых клеток за счет ареста клеточного цикла в фазе G2 /M, а также стимулирует апоптоз и влияет на развитие аутофагии в опухолевых клетках. В данном обзоре обобщены данные о транспорте лития через клеточные мембраны, охарактеризованы его основные внутриклеточные мишени и представлены результаты исследований, в которых литий применялся в экспериментальной терапии рака различной локализации с акцентом на сигнальные пути, влияющие на рост и метастазирование опухолевых клеток.

Recently, lithium salts have been considered as potential compounds for targeted therapy that can reduce tumor growth. There are a large number of publications indicating the effects of lithium on the signaling pathways used by tumor cells for growth and development, and have demonstrated that lithium can be used as antitumor agent in experimental oncology. The promise of using lithium salts to develop anticancer drugs is related to the fact that lithium has 2 main intracellular targets: glycogen synthase kinase-3β (GSK-3β) and inositol monophosphatase (IMPase), the inhibition of which by lithium can induce cancer cell death by apoptosis or autophagy. Lithium has been shown to block the proliferation of cancer cells by cell cycle arrest in the G2 /M phase, and also stimulates apoptosis and autophagy in cancer cells. This review summarizes data on the transport of lithium across cell membranes, characterizes its main intracellular targets and presents the results of studies in which lithium was used in experimental cancer therapy of various localization with an emphasis on signaling pathways used by cancer cells for growth and metastasis.

 

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The authors declare that there are no conflicts of interest present.