sibmedСибирский научный медицинский журналСибирский научный медицинский журнал2410-25122410-2520ИЦиГ СО РАН10.18699/SSMJ20250408sibmed-2338Research ArticleОБЗОРЫREVIEWSМолекулярные звенья патогенеза эндометриоза – потенциальные мишени диагностики и таргетной терапии: обзор литературыMolecular links in endometriosis pathogenesis as targets for diagnosis and targeted therapy: a reviewhttps://orcid.org/0000-0002-4388-5609ЮмашеваВ. А.YumashevaV. A.

Юмашева Валентина Алексеевна

119991, г. Москва, ул. Трубецкая, 8, стр. 2

Valentina A. Yumasheva

119991, Moscow, Trubetskaya st., 8, str. 2

valentina-jumasheva@rambler.ruhttps://orcid.org/0000-0002-6813-3374ЛобановаО. А.LobanovaO. A.

Лобанова Ольга Андреевна

119991, г. Москва, ул. Трубецкая, 8, стр. 2

Olga A. Lobanova

119991, Moscow, Trubetskaya st., 8, str. 2

lobanova.98@mail.ruhttps://orcid.org/0000-0001-5380-7113ПарамоноваН. Б.ParamonovaN. B.

Парамонова Нина Борисовна, к.м.н.

119991, г. Москва, ул. Трубецкая, 8, стр. 2

Nina B. Paramonova, candidate of medical sciences

119991, Moscow, Trubetskaya st., 8, str. 2

paramonova_nina@mail.ruhttps://orcid.org/0009-0002-9859-7601АбашеваД. Д.AbashevaD. D.

Абашева Дарья Денисовна

119991, г. Москва, ул. Трубецкая, 8, стр. 2

Daria D. Abasheva

119991, Moscow, Trubetskaya st., 8, str. 2

daryaabash5@gmail.comПервый Московский государственный медицинский университет им. И.М. Сеченова Минздрава РоссииРоссияI.M. Sechenov First Moscow State Medical University (Sechenov University) of Minzdrav of RussiaRussian Federation2025050920254547889Copyright © Юмашева В.А., Лобанова О.А., Парамонова Н.Б., Абашева Д.Д., 20252025Юмашева В.А., Лобанова О.А., Парамонова Н.Б., Абашева Д.Д.Yumasheva V.A., Lobanova O.A., Paramonova N.B., Abasheva D.D.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://sibmed.elpub.ru/jour/article/view/2338

Эндометриоз является одним из самых распространенных гинекологических заболеваний. Его этиология и патогенез на сегодняшний день не установлены. Актуальными проблемами также являются диагностика и лечение эндометриоза. Существующие теории не объясняют в полной мере причины возникновения и механизмы развития данного заболевания, что не позволяет разработать максимально эффективные тактики лечения и профилактики эндометриоза. Решению этих задач посвящено большое количество современных исследований, среди которых наиболее актуальным является изучение роли различных биомолекул в развитии эндометриоидной болезни. В данном обзоре мы обобщили современные данные по некоторым биомолекулам, которые могут играть важную роль в возникновении эндометриоза: факторам хронического воспаления (М2-ассоциированные факторы, аргиназа-1, CD11b), неоваскуляризации (VEGF, HIF-1α, декорин), инвазии (RPLP1, H3K27me3, TWIST1, RON, CD47, TSP1, SIRPα), аутофагии (LC3B-II, р62, Beclin, NLRC5), а также указывающим на выраженную пролиферативную активность, активный метаболизм в клетках эктопического эндометрия (MCT, GLUT) и формирование нервных волокон (NFASC, CHL1, c-Fos). Изучение данных молекул поможет углубить понимание природы и механизма развития заболевания, разработать диагностический набор его маркеров, а также эффективные методы лечения, в том числе таргетной терапии.

Endometriosis is a common gynecological disorder. Nowadays, its etiology and pathogenesis remain unknown. Its diagnosis and treatment are one of the most urgent problems. Existing theories do not fully explain the causes and mechanisms of the disease development, so the most effective treatment has not yet been found. Due to this fact, we cannot effectively prevent this disease. Many researchers try to solve this problem. The most important issue is studying various biomolecules' role in endometriosis development. In this review, we summarized data on some molecules that may play an important role in endometriosis development, including factors of chronic inflammation (M2-associated markers, arginase 1, CD11b), neovascularization (VEGF, HIF-1α, decorin), invasion (RPLP1, H3K27me3, TWIST1, RON, CD47, TSP1, SIRPα), autophagy (LC3B-II, p62, Beclin, NLRC5), proliferative activity and active metabolism in ectopic endometrial cells (MCT, GLUT), neurogenesis (NFASC, CHL1, c-Fos). The study of these molecules will help to deepen the understanding of the nature and mechanism of the disease, develop a diagnostic set of its markers, as well as effective treatment methods, including targeted therapy.

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The authors declare that there are no conflicts of interest present.