<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="review-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">sibmed</journal-id><journal-title-group><journal-title xml:lang="ru">Сибирский научный медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Сибирский научный медицинский журнал</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2410-2512</issn><issn pub-type="epub">2410-2520</issn><publisher><publisher-name>ИЦиГ СО РАН</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18699/SSMJ20250407</article-id><article-id custom-type="elpub" pub-id-type="custom">sibmed-2337</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>Генетические основы стабильности и удовлетворенности сексуальными отношениями: нарративный обзор</article-title><trans-title-group xml:lang="en"><trans-title>Genetic contributions to sexual relationship dynamics: A narrative review</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0085-3284</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Эскандар</surname><given-names>К.</given-names></name><name name-style="western" xml:lang="en"><surname>Eskandar</surname><given-names>К.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Киролос Эскандар</p><p>4034572, Хелуан, Аль-Масакен Аль-Иктисадия</p></bio><bio xml:lang="en"><p>Eskandar Kirolos</p><p>4034572, Helwan, Al Masaken Al Iqtisadeyah</p></bio><email xlink:type="simple">kiroloss.eskandar@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Хелуанский университет</institution><country>Египет</country></aff><aff xml:lang="en"><institution>Helwan University</institution><country>Egypt</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>05</day><month>09</month><year>2025</year></pub-date><volume>45</volume><issue>4</issue><fpage>65</fpage><lpage>77</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Эскандар К., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Эскандар К.</copyright-holder><copyright-holder xml:lang="en">Eskandar К.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://sibmed.elpub.ru/jour/article/view/2337">https://sibmed.elpub.ru/jour/article/view/2337</self-uri><abstract><p>Стабильность и удовлетворенность сексуальными отношениями играют важную роль в благополучии личности и сплоченности общества. Хотя психологические и социальные факторы, влияющие на эти аспекты, хорошо изучены, генетическая основа этих явлений остается развивающейся областью научных исследований. Цель данного обзора — синтезировать и критически проанализировать результаты генетических исследований, связанных со стабильностью и удовлетворенностью сексуальными отношениями, с акцентом на ключевые генетические механизмы и их значение.</p><sec><title>Материал и методы</title><p>Материал и методы. Обзор включает анализ 42 рецензируемых публикаций, опубликованных в период с 2003 по 2023 г., с фокусом на генетический вклад в стабильность и удовлетворенность в отношениях.</p></sec><sec><title>Результаты</title><p>Результаты. Данные свидетельствуют о том, что невротизм с уровнем наследуемости около 40 % является значимым предиктором нестабильности в отношениях. Напротив, высокий уровень доброжелательности и экстраверсии связан с большей удовлетворенностью. Обзор рассматривает влияние генетики на черты личности, типы привязанности, эмоциональную регуляцию, гормональные факторы, сексуальную совместимость, поведение в коммуникации и предрасположенность к психическим расстройствам. Также подчеркивается взаимодействие генетических и средовых факторов, подтвержденное данными эмпирических исследований и тематическими случаями, демонстрирующими сложность этих взаимосвязей.</p></sec><sec><title>Заключение</title><p>Заключение. Обзор затрагивает этические аспекты и обозначает перспективные направления для будущих исследований, представляя всесторонний взгляд на то, как генетика может формировать успешные сексуальные отношения. Интеграция генетических данных с наукой о межличностных отношениях позволяет получить обоснованные научные выводы для дальнейших междисциплинарных исследований.</p></sec></abstract><trans-abstract xml:lang="en"><p>The stability and satisfaction of sexual relationships are vital for individual well-being and societal cohesion. Although psychological and social influences on these outcomes are well-documented, the study of their genetic underpinnings remains an emerging area of research. This review aims to synthesize and critically analyze genetic research findings related to the stability and satisfaction of sexual relationships, highlighting key genetic mechanisms and their implications.</p><sec><title>Material and methods</title><p>Material and methods. This review synthesizes findings from 42 peer-reviewed publications published between 2003 and 2023, focusing on the genetic contributions to relationship stability and satisfaction.</p></sec><sec><title>Results</title><p>Results. Evidence indicates that neuroticism, with a heritability estimate of approximately 40 %, strongly predicts relationship instability. In contrast, higher levels of agreeableness and extraversion are associated with greater satisfaction. The review examines how genetics influence personality traits, attachment patterns, emotional regulation, hormonal factors, sexual compatibility, communication behaviors, and mental health predispositions. It also highlights the interaction between genetic and environmental influences, supported by case studies and empirical research that demonstrate the complexity of these relationships.</p></sec><sec><title>Conclusions</title><p>Conclusions. This review discusses ethical implications and outlines future research opportunities, providing a comprehensive perspective on how genetics can shape successful sexual partnerships. By integrating genetic research with relationship science, it offers evidence-based insights to guide future interdisciplinary investigations.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>генетика</kwd><kwd>стабильность отношений</kwd><kwd>удовлетворенность отношениями</kwd><kwd>личностные черты</kwd><kwd>стили привязанности</kwd><kwd>эмоциональная регуляция</kwd><kwd>гормональные факторы</kwd><kwd>сексуальная совместимость</kwd><kwd>коммуникативное поведение</kwd><kwd>взаимодействие генов и окружающей среды</kwd></kwd-group><kwd-group xml:lang="en"><kwd>genetics</kwd><kwd>relationship stability</kwd><kwd>relationship satisfaction</kwd><kwd>personality traits</kwd><kwd>attachment patterns</kwd><kwd>emotional regulation</kwd><kwd>hormonal factors</kwd><kwd>sexual compatibility</kwd><kwd>communication behaviors</kwd><kwd>gene-environment interaction</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Gordon A.M., Chen S. The role of sleep in interpersonal conflict. Social Psychological and Personality Science. 2013;5(2):168–175. doi: 10.1177/1948550613488952</mixed-citation><mixed-citation xml:lang="en">Gordon A.M., Chen S. The role of sleep in interpersonal conflict. Social Psychological and Personality Science. 2013;5(2):168–175. doi: 10.1177/1948550613488952</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Plomin R., von Stumm S. The new genetics of intelligence. Nat. Rev. Genet. 2018;19(3):148–159. doi: 10.1038/nrg.2017.104</mixed-citation><mixed-citation xml:lang="en">Plomin R., von Stumm S. The new genetics of intelligence. Nat. Rev. Genet. 2018;19(3):148–159. doi: 10.1038/nrg.2017.104</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Wray N.R., Ripke S., Mattheisen M., Trzaskowski M., Byrne E.M., Abdellaoui A., Adams M.J., Agerbo E., Air T.M., Andlauer T.M.F., … Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium. Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. Nat. Genet. 2018;50(5):668–681. doi: 10.1038/s41588-018-0090-3</mixed-citation><mixed-citation xml:lang="en">Wray N.R., Ripke S., Mattheisen M., Trzaskowski M., Byrne E.M., Abdellaoui A., Adams M.J., Agerbo E., Air T.M., Andlauer T.M.F., … Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium. Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. Nat. Genet. 2018;50(5):668–681. doi: 10.1038/s41588-018-0090-3</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Simpson J.A., Belsky J. Attachment theory within a modern evolutionary framework. In: Handbook of Attachment, Third Edition: Theory, Research, and Clinical Applications. 2016. Available at: clck.ru/3MfgWX</mixed-citation><mixed-citation xml:lang="en">Simpson J.A., Belsky J. Attachment theory within a modern evolutionary framework. In: Handbook of Attachment, Third Edition: Theory, Research, and Clinical Applications. 2016. Available at: clck.ru/3MfgWX</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Canli T., Lesch K.P. Long story short: the serotonin transporter in emotion regulation and social cognition. Nat. Neurosci. 2007;10(9):1103–1109. doi: 10.1038/nn1964</mixed-citation><mixed-citation xml:lang="en">Canli T., Lesch K.P. Long story short: the serotonin transporter in emotion regulation and social cognition. Nat. Neurosci. 2007;10(9):1103–1109. doi: 10.1038/nn1964</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Carter C.S. The oxytocin-vasopressin pathway in the context of love and fear. Front. Endocrinol. (Lausanne). 2017;8:356. doi: 10.3389/fendo.2017.00356</mixed-citation><mixed-citation xml:lang="en">Carter C.S. The oxytocin-vasopressin pathway in the context of love and fear. Front. Endocrinol. (Lausanne). 2017;8:356. doi: 10.3389/fendo.2017.00356</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Roberts S.C., Havlicek J., Flegr J., Hruskova M., Little A.C., Jones B.C., Perrett D.I., Petrie M. Female facial attractiveness increases during the fertile phase of the menstrual cycle. Proc. Biol. Sci. 2004;271(Suppl 5):S270–S272. doi: 10.1098/rsbl.2004.0174</mixed-citation><mixed-citation xml:lang="en">Roberts S.C., Havlicek J., Flegr J., Hruskova M., Little A.C., Jones B.C., Perrett D.I., Petrie M. Female facial attractiveness increases during the fertile phase of the menstrual cycle. Proc. Biol. Sci. 2004;271(Suppl 5):S270–S272. doi: 10.1098/rsbl.2004.0174</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Reis H.T. The role of intimacy in interpersonal relations. Journal of Social and Clinical Psychology. 1990;9(1):15–30. doi: 10.1521/jscp.1990.9.1.15</mixed-citation><mixed-citation xml:lang="en">Reis H.T. The role of intimacy in interpersonal relations. Journal of Social and Clinical Psychology. 1990;9(1):15–30. doi: 10.1521/jscp.1990.9.1.15</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Handbook of depression. 3rd edition. Eds. I.H. Gotlib, C.L. Hammen. Guilford Publications, 2015. 642 p.</mixed-citation><mixed-citation xml:lang="en">Handbook of depression. 3rd edition. Eds. I.H. Gotlib, C.L. Hammen. Guilford Publications, 2015. 642 p.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Adams M.J., Howard D.M., Luciano M., Clarke T.K., Davies G., Hill W.D.; 23 and Me Research Team; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium; Smith D., Deary I.J., Porteous D.J., McIntosh A.M. Genetic stratification of depression by neuroticism: revisiting a diagnostic tradition. Psychol. Med. 2020;50(15):2526– 2535. doi: 10.1017/S0033291719002629</mixed-citation><mixed-citation xml:lang="en">Adams M.J., Howard D.M., Luciano M., Clarke T.K., Davies G., Hill W.D.; 23 and Me Research Team; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium; Smith D., Deary I.J., Porteous D.J., McIntosh A.M. Genetic stratification of depression by neuroticism: revisiting a diagnostic tradition. Psychol. Med. 2020;50(15):2526– 2535. doi: 10.1017/S0033291719002629</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Nagel M., Jansen P.R., Stringer S., Watanabe K., de Leeuw C.A., Bryois J., Savage J.E., Hammerschlag A.R., Skene N.G., Muñoz-Manchado A.B., … Posthuma D. Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways. Nat. Genet. 2018;50(7):920–927. doi: 10.1038/s41588-018-0151-7</mixed-citation><mixed-citation xml:lang="en">Nagel M., Jansen P.R., Stringer S., Watanabe K., de Leeuw C.A., Bryois J., Savage J.E., Hammerschlag A.R., Skene N.G., Muñoz-Manchado A.B., … Posthuma D. Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways. Nat. Genet. 2018;50(7):920–927. doi: 10.1038/s41588-018-0151-7</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Lo M.T., Hinds D.A., Tung J.Y., Franz C., Fan C.C., Wang Y., Smeland O.B., Schork A., Holland D., Kauppi K., … Chen C.H. Genome-wide analyses for personality traits identify six genomic loci and show correlations with psychiatric disorders. Nat. Genet. 2017;49(1):152–156. doi: 10.1038/ng.3736</mixed-citation><mixed-citation xml:lang="en">Lo M.T., Hinds D.A., Tung J.Y., Franz C., Fan C.C., Wang Y., Smeland O.B., Schork A., Holland D., Kauppi K., … Chen C.H. Genome-wide analyses for personality traits identify six genomic loci and show correlations with psychiatric disorders. Nat. Genet. 2017;49(1):152–156. doi: 10.1038/ng.3736</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Maud C., Ryan J., McIntosh J.E., Olsson C.A. The role of oxytocin receptor gene (OXTR) DNA methylation (DNAm) in human social and emotional functioning: a systematic narrative review. BMC Psychiatry. 2018;18(1):154. doi: 10.1186/s12888-018-1740-9</mixed-citation><mixed-citation xml:lang="en">Maud C., Ryan J., McIntosh J.E., Olsson C.A. The role of oxytocin receptor gene (OXTR) DNA methylation (DNAm) in human social and emotional functioning: a systematic narrative review. BMC Psychiatry. 2018;18(1):154. doi: 10.1186/s12888-018-1740-9</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Erkoreka L., Zumarraga M., Arrue A., Zamalloa M.I., Arnaiz A., Olivas O., Moreno-Calle T., Saez E., Garcia J., Marin E., … Basterreche N. Genetics of adult attachment: An updated review of the literature. World J. Psychiatry. 2021;11(9):530–542. doi: 10.5498/wjp.v11.i9.530</mixed-citation><mixed-citation xml:lang="en">Erkoreka L., Zumarraga M., Arrue A., Zamalloa M.I., Arnaiz A., Olivas O., Moreno-Calle T., Saez E., Garcia J., Marin E., … Basterreche N. Genetics of adult attachment: An updated review of the literature. World J. Psychiatry. 2021;11(9):530–542. doi: 10.5498/wjp.v11.i9.530</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Tost H., Champagne F.A., Meyer-Lindenberg A. Environmental influence in the brain, human welfare and mental health. Nat. Neurosci. 2015;18(10):1421– 1431. doi: 10.1038/nn.4108</mixed-citation><mixed-citation xml:lang="en">Tost H., Champagne F.A., Meyer-Lindenberg A. Environmental influence in the brain, human welfare and mental health. Nat. Neurosci. 2015;18(10):1421– 1431. doi: 10.1038/nn.4108</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Riggs S.A., Sahl G., Greenwald E., Atkison H., Paulson A., Ross C.A. Family environment and adult attachment as predictors of psychopathology and personality dysfunction among inpatient abuse survivors. Violence Vict. 2007;22(5):577–600. doi: 10.1891/088667007782312159</mixed-citation><mixed-citation xml:lang="en">Riggs S.A., Sahl G., Greenwald E., Atkison H., Paulson A., Ross C.A. Family environment and adult attachment as predictors of psychopathology and personality dysfunction among inpatient abuse survivors. Violence Vict. 2007;22(5):577–600. doi: 10.1891/088667007782312159</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Verbeke W., Bagozzi R.P., van den Berg W.E. The role of attachment styles in regulating the effects of dopamine on the behavior of salespersons. Front. Hum. Neurosci. 2014;8:32. doi: 10.3389/fnhum.2014.00032</mixed-citation><mixed-citation xml:lang="en">Verbeke W., Bagozzi R.P., van den Berg W.E. The role of attachment styles in regulating the effects of dopamine on the behavior of salespersons. Front. Hum. Neurosci. 2014;8:32. doi: 10.3389/fnhum.2014.00032</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Fearon R.P., Bakermans-Kranenburg M.J., van Ijzendoorn M.H., Lapsley A.M., Roisman G.I. The significance of insecure attachment and disorganization in the development of children’s externalizing behavior: a meta-analytic study. Child Dev. 2010;81(2):435–456. doi: 10.1111/j.1467-8624.2009.01405.x</mixed-citation><mixed-citation xml:lang="en">Fearon R.P., Bakermans-Kranenburg M.J., van Ijzendoorn M.H., Lapsley A.M., Roisman G.I. The significance of insecure attachment and disorganization in the development of children’s externalizing behavior: a meta-analytic study. Child Dev. 2010;81(2):435–456. doi: 10.1111/j.1467-8624.2009.01405.x</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Hariri A.R., Holmes A. Genetics of emotional regulation: the role of the serotonin transporter in neural function. Trends Cogn. Sci. 2006;10(4):182–191. doi: 10.1016/j.tics.2006.02.011</mixed-citation><mixed-citation xml:lang="en">Hariri A.R., Holmes A. Genetics of emotional regulation: the role of the serotonin transporter in neural function. Trends Cogn. Sci. 2006;10(4):182–191. doi: 10.1016/j.tics.2006.02.011</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Gotlib I.H., Joormann J., Foland-Ross L.C. Understanding familial risk for depression: A 25-year perspective. Perspect. Psychol. Sci. 2014;9(1):94–108. doi: 10.1177/1745691613513469</mixed-citation><mixed-citation xml:lang="en">Gotlib I.H., Joormann J., Foland-Ross L.C. Understanding familial risk for depression: A 25-year perspective. Perspect. Psychol. Sci. 2014;9(1):94–108. doi: 10.1177/1745691613513469</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Bardel G., Gross A.T., Neacsiu C.B. The neural circuitry of emotional regulation: evidence from multimodal imaging. Neurosci. Biomed. Eng. 2024;1(1):27– 41. doi: 10.35335/pwa46w25</mixed-citation><mixed-citation xml:lang="en">Bardel G., Gross A.T., Neacsiu C.B. The neural circuitry of emotional regulation: evidence from multimodal imaging. Neurosci. Biomed. Eng. 2024;1(1):27– 41. doi: 10.35335/pwa46w25</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Walum H., Westberg L., Henningsson S., Neiderhiser J.M., Reiss D., Igl W., Ganiban J.M., Spotts E.L., Pedersen N.L., Eriksson E., Lichtenstein P. Genetic variation in the vasopressin receptor 1a gene (AVPR1A) associates with pair-bonding behavior in humans. Proc. Natl. Acad. Sci. USA. 2008;105(37):14153–14156. doi: 10.1073/pnas.0803081105</mixed-citation><mixed-citation xml:lang="en">Walum H., Westberg L., Henningsson S., Neiderhiser J.M., Reiss D., Igl W., Ganiban J.M., Spotts E.L., Pedersen N.L., Eriksson E., Lichtenstein P. Genetic variation in the vasopressin receptor 1a gene (AVPR1A) associates with pair-bonding behavior in humans. Proc. Natl. Acad. Sci. USA. 2008;105(37):14153–14156. doi: 10.1073/pnas.0803081105</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Feldman R. What is resilience: an affiliative neuroscience approach. World Psychiatry. 2020;19(2):132– 150. doi: 10.1002/wps.20729</mixed-citation><mixed-citation xml:lang="en">Feldman R. What is resilience: an affiliative neuroscience approach. World Psychiatry. 2020;19(2):132– 150. doi: 10.1002/wps.20729</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Roberts S.C., Gosling L.M., Carter V., Petrie M. MHC-correlated odour preferences in humans and the use of oral contraceptives. Proc. Biol. Sci. 2008;275(1652):2715–2722. doi: 10.1098/rspb.2008.0825</mixed-citation><mixed-citation xml:lang="en">Roberts S.C., Gosling L.M., Carter V., Petrie M. MHC-correlated odour preferences in humans and the use of oral contraceptives. Proc. Biol. Sci. 2008;275(1652):2715–2722. doi: 10.1098/rspb.2008.0825</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Winternitz J., Abbate J.L., Huchard E., Havlíček J., Garamszegi L.Z. Patterns of MHC-dependent mate selection in humans and nonhuman primates: a meta-analysis. Mol. Ecol. 2017;26(2):668–688. doi: 10.1111/mec.13920</mixed-citation><mixed-citation xml:lang="en">Winternitz J., Abbate J.L., Huchard E., Havlíček J., Garamszegi L.Z. Patterns of MHC-dependent mate selection in humans and nonhuman primates: a meta-analysis. Mol. Ecol. 2017;26(2):668–688. doi: 10.1111/mec.13920</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Milinski M., Wedekind C. Evidence for MHCcorrelated perfume preferences in humans. Behavioral Ecol. 2001;12(2):140–149. doi: 10.1093/beheco/12.2.140</mixed-citation><mixed-citation xml:lang="en">Milinski M., Wedekind C. Evidence for MHCcorrelated perfume preferences in humans. Behavioral Ecol. 2001;12(2):140–149. doi: 10.1093/beheco/12.2.140</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Gottesman I.I., Gould T.D. The endophenotype concept in psychiatry: etymology and strategic intentions. Am. J. Psychiatry. 2003;160(4):636–645. doi: 10.1176/appi.ajp.160.4.636</mixed-citation><mixed-citation xml:lang="en">Gottesman I.I., Gould T.D. The endophenotype concept in psychiatry: etymology and strategic intentions. Am. J. Psychiatry. 2003;160(4):636–645. doi: 10.1176/appi.ajp.160.4.636</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Caspi A., Moffitt T.E. Gene-environment interactions in psychiatry: joining forces with neuroscience. Nat. Rev. Neurosci. 2006;7(7):583–590. doi: 10.1038/nrn1925</mixed-citation><mixed-citation xml:lang="en">Caspi A., Moffitt T.E. Gene-environment interactions in psychiatry: joining forces with neuroscience. Nat. Rev. Neurosci. 2006;7(7):583–590. doi: 10.1038/nrn1925</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Belsky J., Pluess M. Beyond diathesis stress: differential susceptibility to environmental influences. Psychol. Bull. 2009;135(6):885–908. doi: 10.1037/a0017376</mixed-citation><mixed-citation xml:lang="en">Belsky J., Pluess M. Beyond diathesis stress: differential susceptibility to environmental influences. Psychol. Bull. 2009;135(6):885–908. doi: 10.1037/a0017376</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Spotts E.L., Neiderhiser J.M., Towers H., Hansson K., Lichtenstein P., Cederblad M., Pederson N.L., Reiss D. Genetic and environmental influences on marital relationships. J. Fam. Psychol. 2004;18(1):107–119. doi: 10.1037/0893-3200.18.1.107</mixed-citation><mixed-citation xml:lang="en">Spotts E.L., Neiderhiser J.M., Towers H., Hansson K., Lichtenstein P., Cederblad M., Pederson N.L., Reiss D. Genetic and environmental influences on marital relationships. J. Fam. Psychol. 2004;18(1):107–119. doi: 10.1037/0893-3200.18.1.107</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Starr L.R., Hammen C., Brennan P.A., Najman J.M. Serotonin transporter gene as a predictor of stress generation in depression. J. Abnorm. Psychol. 2012;121(4):810–818. doi: 10.1037/a0027952</mixed-citation><mixed-citation xml:lang="en">Starr L.R., Hammen C., Brennan P.A., Najman J.M. Serotonin transporter gene as a predictor of stress generation in depression. J. Abnorm. Psychol. 2012;121(4):810–818. doi: 10.1037/a0027952</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Luo S., Yu D., Han S. Genetic and neural correlates of romantic relationship satisfaction. Soc. Cogn. Affect. Neurosci. 2016;11(2):337–348. doi: 10.1093/scan/nsv117</mixed-citation><mixed-citation xml:lang="en">Luo S., Yu D., Han S. Genetic and neural correlates of romantic relationship satisfaction. Soc. Cogn. Affect. Neurosci. 2016;11(2):337–348. doi: 10.1093/scan/nsv117</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">O’Connell K.S., Coombes B.J. Genetic contributions to bipolar disorder: current status and future directions. Psychol. Med. 2021;51(13):2156–2167. doi: 10.1017/S0033291721001252</mixed-citation><mixed-citation xml:lang="en">O’Connell K.S., Coombes B.J. Genetic contributions to bipolar disorder: current status and future directions. Psychol. Med. 2021;51(13):2156–2167. doi: 10.1017/S0033291721001252</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Khabour O.F., Abu-Siniyeh A.A., Alzoubi K.H., Al-Sheyab N.A. Challenges faced by behavioral genetic studies: researchers perspective from the MENA region. Curr. Genomics. 2021;22(7):550–556. doi: 10.2174/1389202923666211216162141</mixed-citation><mixed-citation xml:lang="en">Khabour O.F., Abu-Siniyeh A.A., Alzoubi K.H., Al-Sheyab N.A. Challenges faced by behavioral genetic studies: researchers perspective from the MENA region. Curr. Genomics. 2021;22(7):550–556. doi: 10.2174/1389202923666211216162141</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Nuffield Council on Bioethics. Genetics and human behaviour: the ethical context. J. Int. Bioethique. 2003;14(3-4):171–192.</mixed-citation><mixed-citation xml:lang="en">Nuffield Council on Bioethics. Genetics and human behaviour: the ethical context. J. Int. Bioethique. 2003;14(3-4):171–192.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Hawkins A.K., Ho A. Genetic counseling and the ethical issues around direct-to-consumer genetic testing. J. Genet. Couns. 2012;21(3):367–373. doi: 10.1007/s10897-012-9488-8</mixed-citation><mixed-citation xml:lang="en">Hawkins A.K., Ho A. Genetic counseling and the ethical issues around direct-to-consumer genetic testing. J. Genet. Couns. 2012;21(3):367–373. doi: 10.1007/s10897-012-9488-8</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">McGuire A.L., Gabriel S., Tishkoff S.A., Wonkam A., Chakravarti A., Furlong E.E.M., Treutlein B., Meissner A., Chang H.Y., López-Bigas N., Segal E., Kim J.S. The road ahead in genetics and genomics. Nat. Rev. Genet. 2020;21(10):581–596. doi: 10.1038/s41576-020-0272-6</mixed-citation><mixed-citation xml:lang="en">McGuire A.L., Gabriel S., Tishkoff S.A., Wonkam A., Chakravarti A., Furlong E.E.M., Treutlein B., Meissner A., Chang H.Y., López-Bigas N., Segal E., Kim J.S. The road ahead in genetics and genomics. Nat. Rev. Genet. 2020;21(10):581–596. doi: 10.1038/s41576-020-0272-6</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Armitage J.M., Wang R.A.H., Davis O.S.P., Haworth C.M.A. A polygenic approach to understanding resilience to peer victimisation. Behav. Genet. 2022;52(1):1–12. doi: 10.1007/s10519-021-10085-5</mixed-citation><mixed-citation xml:lang="en">Armitage J.M., Wang R.A.H., Davis O.S.P., Haworth C.M.A. A polygenic approach to understanding resilience to peer victimisation. Behav. Genet. 2022;52(1):1–12. doi: 10.1007/s10519-021-10085-5</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Bigos K.L., Hariri A.R. Neuroimaging: technologies at the interface of genes, brain, and behavior. Neuroimaging. Clin. N. Am. 2007;17(4):459–467. doi: 10.1016/j.nic.2007.09.005</mixed-citation><mixed-citation xml:lang="en">Bigos K.L., Hariri A.R. Neuroimaging: technologies at the interface of genes, brain, and behavior. Neuroimaging. Clin. N. Am. 2007;17(4):459–467. doi: 10.1016/j.nic.2007.09.005</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Race and Health Observatory. Ethnic inequities in genomics and precision medicine: review report. 2024. Available at: https://www.nhsrho.org/research/ethnic-inequities-in-genomics-and-precision-medicinereview-report/</mixed-citation><mixed-citation xml:lang="en">Race and Health Observatory. Ethnic inequities in genomics and precision medicine: review report. 2024. Available at: https://www.nhsrho.org/research/ethnic-inequities-in-genomics-and-precision-medicinereview-report/</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Lee H., Yoon D.E., Kim K. Genome editing methods in animal models. Anim. Cells Syst. (Seoul). 2020;24(1):8–16. doi: 10.1080/19768354.2020.1726462</mixed-citation><mixed-citation xml:lang="en">Lee H., Yoon D.E., Kim K. Genome editing methods in animal models. Anim. Cells Syst. (Seoul). 2020;24(1):8–16. doi: 10.1080/19768354.2020.1726462</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Relationship science: integrating evolutionary, neuroscience, and sociocultural approaches. Eds.: O. Gillath, G. Adams, A. Kunkel. Washington: Amer. psychol. assoc., 2012. 254 p.</mixed-citation><mixed-citation xml:lang="en">Relationship science: integrating evolutionary, neuroscience, and sociocultural approaches. Eds.: O. Gillath, G. Adams, A. Kunkel. Washington: Amer. psychol. assoc., 2012. 254 p.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
