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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">sibmed</journal-id><journal-title-group><journal-title xml:lang="ru">Сибирский научный медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Сибирский научный медицинский журнал</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2410-2512</issn><issn pub-type="epub">2410-2520</issn><publisher><publisher-name>ИЦиГ СО РАН</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18699/SSMJ20250317</article-id><article-id custom-type="elpub" pub-id-type="custom">sibmed-2252</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКАЯ МЕДИЦИНА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL MEDICINE</subject></subj-group></article-categories><title-group><article-title>Место синдрома распада опухоли среди причин смерти больных онкогематологическими заболеваниями (на примере Пензенской области)</article-title><trans-title-group xml:lang="en"><trans-title>The place of tumor lysis syndrome among causes of death in patients with oncohematological diseases (on the example of the Penza region)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1333-0151</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Комарова</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Komarova</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Екатерина Валентиновна Комарова, к. б. н.</p><p>440026; ул. Красная, 40; Пенза</p></bio><bio xml:lang="en"><p>Ekaterina V. Komarova, candidate of biological sciences</p><p>440026; Krasnaya st., 40; Penza</p></bio><email xlink:type="simple">ekaterina-log@inbox.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4177-8460</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Федорова</surname><given-names>М. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Fedorova</surname><given-names>M. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мария Геннадьевна Федорова, к. м. н.</p><p>440026; ул. Красная, 40; Пенза</p></bio><bio xml:lang="en"><p>Mariya G. Fedorova, candidate of medical sciences</p><p>440026; Krasnaya st., 40; Penza</p></bio><email xlink:type="simple">fedorovamerry@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0008-8720-4570</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пивцаева</surname><given-names>Е. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Pivtsaeva</surname><given-names>E. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Елизавета Константиновна Пивцаева</p><p>440026; ул. Красная, 40; Пенза</p></bio><bio xml:lang="en"><p>Elizaveta K. Pivtsaeva</p><p>440026; Krasnaya st., 40; Penza</p></bio><email xlink:type="simple">Pivtsaeva_liza13@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0002-7361-5738</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Трифонова</surname><given-names>С. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Trifonova</surname><given-names>S. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Софья Константиновна Трифонова</p><p>440026; ул. Красная, 40; Пенза</p></bio><bio xml:lang="en"><p>Sofia K. Trifonova</p><p>440026; Krasnaya st., 40; Penza</p></bio><email xlink:type="simple">sofatrifonova13@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Пензенский государственный университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Penza State University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>13</day><month>07</month><year>2025</year></pub-date><volume>45</volume><issue>3</issue><fpage>147</fpage><lpage>152</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Комарова Е.В., Федорова М.Г., Пивцаева Е.К., Трифонова С.К., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Комарова Е.В., Федорова М.Г., Пивцаева Е.К., Трифонова С.К.</copyright-holder><copyright-holder xml:lang="en">Komarova E.V., Fedorova M.G., Pivtsaeva E.K., Trifonova S.K.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://sibmed.elpub.ru/jour/article/view/2252">https://sibmed.elpub.ru/jour/article/view/2252</self-uri><abstract><p>   Несмотря на активное развитие диагностики, терапии и накопление знаний в онкологии, показатели смертности от злокачественных новообразований (ЗНО) по сей день сохраняются высокими по всему миру. Причина заключается в несвоевременности постановки диагноза, оказания помощи и некорректности назначенной терапии, с которой, помимо возможной неэффективности лечения, тесно связано развитие жизнеугрожающего состояния: синдрома распада опухоли (СРО).</p><p>   Цель исследования – определить распространенность СРО в зависимости от вида диагностированного ЗНО у пациентов онкологического профиля на примере данных Пензенской области за 2021–2023 гг.</p><sec><title>   Материал и методы</title><p>   Материал и методы. Проанализированы данные Региональной информационно-аналитической медицинской системы «ПроМед». Смертность изучалась в период с 2021 по 2023 гг.</p></sec><sec><title>   Результаты</title><p>   Результаты. Зафиксировано 16 случаев смертей от ЗНО, сопровождающихся СРО, что составляет 0,4 % от общего числа летальных случаев вследствие ЗНО. В основном СРО сопровождал ЗНО легких и бронхов – 25 % случаев, ЗНО сигмовидной кишки – 12,5 % и ЗНО гортани – 12,5 % от общего числа случаев СРО за указанный период, несмотря на показания глобальной статистики с указанием наибольшей частоты встречаемости СРО среди гематологических и лимфопролиферативных видов рака.</p></sec><sec><title>   Заключение</title><p>   Заключение. Установлено преобладание СРО при ЗНО легких, бронхов, гортани и сигмовидной кишки. СРО крайне редко сопровождает ЗНО. Увеличение частоты выявления СРО за 2021–2023 гг. показывает совершенствование методов диагностики синдрома.</p></sec></abstract><trans-abstract xml:lang="en"><p>   Despite the active development of diagnostics, therapy and accumulation of knowledge in oncology, mortality rates from malignant neoplasms remain high all over the world to this day. The reason is the untimely diagnosis, provision of assistance and incorrectness of the prescribed therapy. The latter, in addition to the possible ineffectiveness of treatment, is closely associated with the development of a life-threatening condition: tumor lysis syndrome (TLS).</p><p>   Aim of the study was to determine the prevalence of TLS depending on the type of diagnosed malignant neoplasm in cancer patients using the example of data from the Penza region for 2021-2023.</p><sec><title>   Material and methods</title><p>   Material and methods. The data of the Regional Information and Analytical Medical System “ProMed” were analyzed. Mortality was studied during the period from 2021 to 2023.</p></sec><sec><title>   Results</title><p>   Results. There were 16 cases of deaths from malignant neoplasms accompanied by TLS, which constitutes 0.4 % of the total number of deaths due to malignant neoplasms. TLS mainly accompanied malignant neoplasms of the lungs and bronchi – 25 % of cases, malignant neoplasms of the sigmoid colon – 12.5 % and malignant neoplasms of the larynx – 12.5 % of the total number of TLS cases for the specified period, despite global statistics indicating the highest incidence of TLS among hematological and lymphoproliferative types of cancer.</p></sec><sec><title>   Conclusion</title><p>   Conclusion. The prevalence of TLS in malignant neoplasms of the lungs, bronchi, larynx and sigmoid colon has been established. TLS extremely rarely accompanies malignant neoplasms. The increase in the frequency of detection of tumor disintegration syndrome in 2021–2023 shows the improvement of diagnostic methods for the syndrome.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>синдром распада опухоли</kwd><kwd>смертность</kwd><kwd>метаболиты</kwd><kwd>терапия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>tumor lysis syndrome</kwd><kwd>mortality</kwd><kwd>metabolites</kwd><kwd>therapy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Koura S., Parekh V., Parikh A.D., Kaur K., Dunn B.K. Spontaneous tumor lysis syndrome secondary to metastatic small cell lung cancer. Cureus. 2023;15(2):e34557. doi: 10.7759/cureus.34557</mixed-citation><mixed-citation xml:lang="en">Koura S., Parekh V., Parikh A.D., Kaur K., Dunn B.K. Spontaneous tumor lysis syndrome secondary to metastatic small cell lung cancer. 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