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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">sibmed</journal-id><journal-title-group><journal-title xml:lang="ru">Сибирский научный медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Сибирский научный медицинский журнал</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2410-2512</issn><issn pub-type="epub">2410-2520</issn><publisher><publisher-name>ИЦиГ СО РАН</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18699/SSMJ20250205</article-id><article-id custom-type="elpub" pub-id-type="custom">sibmed-2073</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>АНАТОМИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ANATOMY</subject></subj-group></article-categories><title-group><article-title>Сравнительная морфотопометрическая характеристика TI - и TVI -позвонков человека в первом периоде зрелого возраста и в пожилом возрасте</article-title><trans-title-group xml:lang="en"><trans-title>Comparative morpho-topometric characteristics of human TI  and TVI  vertebrae in the first period of adulthood and old age</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3152-8380</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Баландин</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Balandin</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Баландин Анатолий Александрович, д.м.н.</p><p>414099, Пермь, ул. Петропавловская, 26 </p></bio><bio xml:lang="en"><p>Anatolii A. Balandin, doctor of medical sciences</p><p>614990, Perm, Petropavlovskaya st., 26 </p></bio><email xlink:type="simple">balandinnauka@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0007-7022-8499</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чудинов</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Chudinov</surname><given-names>O. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Чудинов Олег Анатольевич</p><p>414099, Пермь, ул. Петропавловская, 26 </p></bio><bio xml:lang="en"><p> Oleg A. Chudinov </p><p>614990, Perm, Petropavlovskaya st., 26</p></bio><email xlink:type="simple">g89223641902@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4856-9066</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Баландина</surname><given-names>И. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Balandina</surname><given-names>I. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Баландина Ирина Анатольевна, д.м.н., проф. </p><p>414099, Пермь, ул. Петропавловская, 26 </p></bio><bio xml:lang="en"><p> Irina A. Balandina, doctor of medical sciences, professor </p><p>614990, Perm, Petropavlovskaya st., 26</p></bio><email xlink:type="simple">balandina_ia@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Пермский государственный медицинский университет им. академика Е.А. Вагнера</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Perm State Medical University named after academician E.A. Vagner</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>06</day><month>05</month><year>2025</year></pub-date><volume>45</volume><issue>2</issue><fpage>57</fpage><lpage>63</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Баландин А.А., Чудинов О.А., Баландина И.А., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Баландин А.А., Чудинов О.А., Баландина И.А.</copyright-holder><copyright-holder xml:lang="en">Balandin A.A., Chudinov O.A., Balandina I.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://sibmed.elpub.ru/jour/article/view/2073">https://sibmed.elpub.ru/jour/article/view/2073</self-uri><abstract><p>Цель исследования – провести сравнительный анализ линейных размеров TI- и TVI-позвонков у мужчин и женщин в первом периоде зрелого возраста и в пожилом возрасте по данным компьютерной томографии грудной клетки. Материал и методы. В основу работы положены результаты компьютерной томографии у 70 пациентов приемного отделения ГКБ № 3 города Перми в 2023–2024 гг. Исследование выполняли на компьютерном томографе Optima CT660 (GE HealthCare, США), измеряли высоту, ширину и переднезадний размер TI- и TVIпозвонков. В выборку попали лица с нормальной массой тела, мезоморфным типом телосложения, без травм и аномалий развития скелета в анамнезе. Обследованных разделили на две группы: 30 человек первого периода зрелого возраста (14 мужчин 22–35 лет и 16 женщин 21–35 лет) и 40 лиц пожилого возраста (20 мужчин 61–75 лет и 20 женщин 60–75 лет). Результаты. Высота и ширина TI- и TVI-позвонков как у мужчин, так и у женщин в первом периоде зрелого возраста и пожилом возрасте не различаются (p &gt; 0,05). Возрастные изменения переднезаднего размера TI-позвонка у женщин заключаются в его увеличении (p &lt; 0,05), в то время как у мужчин параметры не изменяются (p &gt; 0,05). Переднезадний размер TVI-позвонка как у мужчин, так и у женщин к пожилому возрасту не изменяется (p &gt; 0,05). Признаков полового диморфизма исследуемых размеров позвонковне обнаружено (p &gt; 0,05). Заключение. Для проведения различных диагностическо-лечебных манипуляций в области грудного отдела позвоночного столба врачу-специалисту необходим солидный багаж знаний о морфотопометрических особенностях позвонков, связанных с возрастом и полом обследуемого. Результаты данного исследования послужат научным фундаментом для создания нормативных оценочных таблиц и станут отправными точками в дальнейших исследованиях.</p></abstract><trans-abstract xml:lang="en"><p>Aim of the study was to conduct a comparative analysis of the linear dimensions of TI and TVI vertebrae in men and women in the first period of adulthood and in old age according to computed tomography (CT) of the chest. Material and methods: The work is based on CT results of 70 patients of the admission department of the State Clinical Hospital N 3 in Perm in 2023–2024. All patients agreed to a study conducted to exclude possible lung pathology. CT examination was performed on an Optima 660 computed tomograph (GE HealthCare, USA), the height, width and anteroposterior size of the TI and TVI vertebrae were measured. The sample included subjects with normal body weight, mesomorphic body type, without injuries and skeletal abnormalities in the anamnesis. The patients were divided into two groups: 30 people of the first period of adulthood (14 men aged 22–35 years and 16 women aged 21–35 years) and 40 elderly people (20 men aged 61–75 years and 20 women aged 60–75 years). Results. The height and width of TI and TVI vertebrae in both men and women in the first period of adulthood and old age do not differ (p &gt; 0.05). Age-related changes in the anteroposterior size of the TI vertebra in women consist in its increase (p &lt; 0.05), while in men the parameters do not change (p &gt; 0.05). The anterior-posterior size of the TVI vertebra in both men and women do not change (p &gt; 0.05). No signs of sexual dimorphism of the studied vertebral sizes were found (p &gt; 0.05). Conclusions. To carry out various diagnostic and therapeutic manipulations in the thoracic spine, a specialist doctor needs a solid body of knowledge about the morphotopometric features of the vertebrae associated with the age and gender of the subject. The results of this study will serve as a scientific foundation for the creation of normative evaluation tables and will become starting points for further research.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>возраст</kwd><kwd>морфометрия</kwd><kwd>позвонок ТI и TVI</kwd><kwd>компьютерная томография</kwd></kwd-group><kwd-group xml:lang="en"><kwd>age</kwd><kwd>morphometry</kwd><kwd>vertebra TI and TVI</kwd><kwd>computed tomography</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Баландин А.А., Юрушбаева Г.С., Баландина И.А. Возрастная корреляционная взаимосвязь показателей площадей мозолистого тела и ствола головного мозга. Сиб. науч. мед. ж. 2022;42(3):70–75. doi: 10.18699/SSMJ20220309</mixed-citation><mixed-citation xml:lang="en">Balandin A.A., Yurushbaeva G.S., Balandina I.A. Age correlation of cerebral corpus callosum and brainstem area indicators. Sibirskij nauchnyj medicinskij zhurnal = Siberian Scientific Medical Journal. 2022;42(3):70–75. [In Russian]. doi: 10.18699/SSMJ20220309</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Schumacher B., Pothof J., Vijg J., Hoeijmakers J.H.J. The central role of DNA damage in the ageing process. Nature. 2021;592(7856):695–703. doi: 10.1038/s41586-021-03307-7</mixed-citation><mixed-citation xml:lang="en">Schumacher B., Pothof J., Vijg J., Hoeijmakers J.H.J. The central role of DNA damage in the ageing process. Nature. 2021;592(7856):695–703. doi: 10.1038/s41586-021-03307-7</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Distefano G., Goodpaster B.H. Effects of exercise and aging on skeletal muscle. Cold Spring Harb. Perspect. Med. 2018;8(3):a029785. doi: 10.1101/cshperspect.a029785</mixed-citation><mixed-citation xml:lang="en">Distefano G., Goodpaster B.H. Effects of exercise and aging on skeletal muscle. Cold Spring Harb. Perspect. Med. 2018;8(3):a029785. doi: 10.1101/cshperspect.a029785</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Balandina I.A., Balandin A.A., Balandin V.A., Zheleznov L.M. Regularities of organometric characteristics of cerebellum in young and old age. Journal of Global Pharma Technology. 2017;9(3):49–53.</mixed-citation><mixed-citation xml:lang="en">Balandina I.A., Balandin A.A., Balandin V.A., Zheleznov L.M. Regularities of organometric characteristics of cerebellum in young and old age. Journal of Global Pharma Technology. 2017;9(3):49–53.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Michaud F., Lugrís U., Cuadrado J. Determination of the 3D human spine posture from wearable inertial sensors and a multibody model of the spine. Sensors (Basel). 2022;22(13):4796. doi: 10.3390/s22134796</mixed-citation><mixed-citation xml:lang="en">Michaud F., Lugrís U., Cuadrado J. Determination of the 3D human spine posture from wearable inertial sensors and a multibody model of the spine. Sensors (Basel). 2022;22(13):4796. doi: 10.3390/s22134796</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Graham A. Vertebrate evolution: turning heads. Curr. Biol. 2005;15(18):R764–766. doi: 10.1016/j.cub.2005.08.060</mixed-citation><mixed-citation xml:lang="en">Graham A. Vertebrate evolution: turning heads. Curr. Biol. 2005;15(18):R764–766. doi: 10.1016/j.cub.2005.08.060</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Ferguson S.J., Steffen T. Biomechanics of the aging spine. Eur. Spine. J. 2003;12(Suppl 2):97–103. doi: 10.1007/s00586-003-0621-0</mixed-citation><mixed-citation xml:lang="en">Ferguson S.J., Steffen T. Biomechanics of the aging spine. Eur. Spine. J. 2003;12(Suppl 2):97–103. doi: 10.1007/s00586-003-0621-0</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Liebsch C., Wilke H.J. How does the rib cage affect the biomechanical properties of the thoracic spine? A systematic literature review. Front. Bioeng. Biotechnol. 2022;10:904539. doi: 10.3389/fbioe.2022.904539</mixed-citation><mixed-citation xml:lang="en">Liebsch C., Wilke H.J. How does the rib cage affect the biomechanical properties of the thoracic spine? A systematic literature review. Front. Bioeng. Biotechnol. 2022;10:904539. doi: 10.3389/fbioe.2022.904539</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Сонголов Г.И., Галеева О.П., Редков С.Н. Клиническая анатомия и современные информационные технологии прижизненной визуализации. Система менеджмента качества: опыт и перспективы. 2014;(3):77–81.</mixed-citation><mixed-citation xml:lang="en">Songolov G.I., Galeeva O.P., Redkov S.N. Clinical anatomy and modern information technologies of in vivo imaging. Sistema menedzhmenta kachestva: opyt i perspektivy = Quality Management System: Experience and Prospects. 2014;(3):77–81. [In Russian].</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Nazia Fathima S.M., Tamilselvi R., Beham M.P. Role of X-rays in assessment of bone mineral density – a review. In: Innovations in Electronics and Communication Engineering. Eds. H Saini, R. Singh, G. Kumar, G. Rather, K. Santhi. Singapore: Springer, 2019. Vol. 65. Р. 51–59. doi: 10.1007/978-981-13-3765-9_6</mixed-citation><mixed-citation xml:lang="en">Nazia Fathima S.M., Tamilselvi R., Beham M.P. Role of X-rays in assessment of bone mineral density – a review. In: Innovations in Electronics and Communication Engineering. Eds. H Saini, R. Singh, G. Kumar, G. Rather, K. Santhi. Singapore: Springer, 2019. Vol. 65. Р. 51–59. doi: 10.1007/978-981-13-3765-9_6</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Wang X.B., Zheng X., Long H.Q., Chen W.L., Cheng X., Huang Y.L., Xu J.H. Ideal T1 laminar screw fixation based on computed tomography morphometry. BMC Musculoskelet Disord. 2017;18(1):241. doi: 10.1186/s12891-017-1604-3</mixed-citation><mixed-citation xml:lang="en">Wang X.B., Zheng X., Long H.Q., Chen W.L., Cheng X., Huang Y.L., Xu J.H. Ideal T1 laminar screw fixation based on computed tomography morphometry. BMC Musculoskelet Disord. 2017;18(1):241. doi: 10.1186/s12891-017-1604-3</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Gattozzi D.A., Friis L.A., Arnold P.M. Surgery for traumatic fractures of the upper thoracic spine (T1- T6). Surg. Neurol. Int. 2018;9:231. doi: 10.4103/sni.sni_273_18</mixed-citation><mixed-citation xml:lang="en">Gattozzi D.A., Friis L.A., Arnold P.M. Surgery for traumatic fractures of the upper thoracic spine (T1- T6). Surg. Neurol. Int. 2018;9:231. doi: 10.4103/sni.sni_273_18</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Arijón I.E., Galeiras R., Quiroga L.S., Velasco M.E.F., Pértega Díaz S. Trends in the presentation and management of traumatic spinal cord lesions above T6: 20-Year experience in a tertiary-level hospital in Spain. J. Spinal Cord Med. 2022;45(5):720–727. doi: 10.1080/10790268.2020.1851857</mixed-citation><mixed-citation xml:lang="en">Arijón I.E., Galeiras R., Quiroga L.S., Velasco M.E.F., Pértega Díaz S. Trends in the presentation and management of traumatic spinal cord lesions above T6: 20-Year experience in a tertiary-level hospital in Spain. J. Spinal Cord Med. 2022;45(5):720–727. doi: 10.1080/10790268.2020.1851857</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Анисимова Е.А., Зоткин В.В., Анисимов Д.И., Челнокова Н.О., Попрыга Д.В., Мечева Т.В. Топографическая изменчивость и корреляции абсолютных и относительных размеров грудных позвонков взрослых людей. Соврем. пробл. науки и образ. 2020;(2):150.</mixed-citation><mixed-citation xml:lang="en">Anisimova E.A., Zotkin V.V., Anisimov D.I., Chelnokova N.O., Popryga D.V., Mecheva T.V. Topographic variability and correlations of absolute and relative sizes of thoracic vertebrae of adults. Sovremennye problem nauki i obrazovaniya = Modern Problems of Science and Education. 2020;(2):150. [In Russian].</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Singh R., Srivastva S.K., Prasath C.S., Rohilla R.K., Siwach R., Magu N.K. Morphometric measurements of cadaveric thoracic spine in Indian population and its clinical applications. Asian Spine J. 2011;5(1):20–34. doi: 10.4184/asj.2011.5.1.20</mixed-citation><mixed-citation xml:lang="en">Singh R., Srivastva S.K., Prasath C.S., Rohilla R.K., Siwach R., Magu N.K. Morphometric measurements of cadaveric thoracic spine in Indian population and its clinical applications. Asian Spine J. 2011;5(1):20–34. doi: 10.4184/asj.2011.5.1.20</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Анисимова Е.А., Николенко В.Н., Островский В.В., Тома А.И. Морфометрическое обоснование выбора метода хирургической коррекции повреждений грудного отдела позвоночного столба. Сарат. науч.-мед. ж. 2009;5(2):254–260.</mixed-citation><mixed-citation xml:lang="en">Anisimova E.A., Nikolenko V.N., Ostrovskiy V.V., Toma A.I. Morphometrical substantiation of surgical method choice of damage correction of chest department of spinal column. Saratovskiy nauchno-meditsinskiy zhurnal = Saratov Journal of Medical Scientific Research. 2009;5(2):254–260. [In Russian].</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Мошкин А.С., Николенко В.Н., Халилов М.А. Закономерности в отношениях размеров тел шейных позвонков в аксиальной плоскости при МРТ. Наука и инновации в медицине. 2024;9(1):8–13. doi: 10.35693/SIM601839</mixed-citation><mixed-citation xml:lang="en">Moshkin A.S., Nikolenko V.N., Khalilov M.A.. Regular patterns in the size ratio of the cervical vertebral bodies registered by MRI in the axial plane. Nauka i innovatsii v meditsine = Science and Innovation in Medicine. 2024;9(1):8–13 [In Russian]. doi: 10.35693/SIM601839</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Egwu O.A., Okechukwu G.N., Uzomba G.C., Eze S.O., Ezemagu U.K. Typical thoracic vertebrae morphometry: A cadaveric study in Nigeria. Journal of the Anatomical Society of India 2019;68(2):110–118. doi: 10.4103/JASI.JASI_8_19</mixed-citation><mixed-citation xml:lang="en">Egwu O.A., Okechukwu G.N., Uzomba G.C., Eze S.O., Ezemagu U.K. Typical thoracic vertebrae morphometry: A cadaveric study in Nigeria. Journal of the Anatomical Society of India 2019;68(2):110–118. doi: 10.4103/JASI.JASI_8_19</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Tunckale T., Gurdal S.O., Caliskan T., Topcu B., Yuksel M.O. The impact of various breast sizes of women on vertebral column and spinopelvic parameters. Turk. Neurosurg. 2021;31(5):699–703. doi: 10.5137/1019-5149.JTN.30936-20.2</mixed-citation><mixed-citation xml:lang="en">Tunckale T., Gurdal S.O., Caliskan T., Topcu B., Yuksel M.O. The impact of various breast sizes of women on vertebral column and spinopelvic parameters. Turk. Neurosurg. 2021;31(5):699–703. doi: 10.5137/1019-5149.JTN.30936-20.2</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Иванов М.А., Яшина И.Н., Клочкова С.В., Яшин Ф.Д., Рыбалко Д.Ю. Системные взаимоотношения строения грудных позвонков и околопозвоночных мышц у женщин зрелого возраста по данным компьютерной томографии. Мед. вестн. Башкортостана. 2023;18(6):39–44.</mixed-citation><mixed-citation xml:lang="en">Ivanov M.A., Yashina I.N., Klochkova S.V., Yashin F.D., Rybalko D.Yu. Systemic interaction of the structure of the thoracic vertebrae and paravertebral muscles in mature women according to computed tomography. Meditsinskiy vestnik Bashkortostana = Medical Herald of Bashkrtostan. 2023;18(108):39–44. [In Russian].</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Gilsanz V., Wren T.A.L., Ponrartana S., Mora S., Rosen C.J. Sexual dimorphism and the origins of human spinal health. Endocr. Rev. 2018;39(2):221–239. doi: 10.1210/er.2017-00147</mixed-citation><mixed-citation xml:lang="en">Gilsanz V., Wren T.A.L., Ponrartana S., Mora S., Rosen C.J. Sexual dimorphism and the origins of human spinal health. Endocr. Rev. 2018;39(2):221–239. doi: 10.1210/er.2017-00147</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
